Zobrazeno 1 - 10 of 100 pro vyhledávání: '"H, Gourdeau"'
1
Evidence for trans regulation of apoptosis in intertypic somatic cell hybrids
Autor: H Gourdeau, P R Walker
Publikováno v: Molecular and Cellular Biology. 14:6125-6134
The genetic components required for glucocorticoid induction of apoptosis were studied by using somatic cell hybridization. Intertypic whole-cell hybrids were generated by crossing the glucocorticoid-resistant rat liver cell line Fado-2 with the gluc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ccd6224c24db285fd4922aab6f19a8b
https://doi.org/10.1128/mcb.14.9.6125
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2
The pro-apoptotic protein, Bik, exhibits potent antitumor activity that is dependent on its BH3 domain
Autor: Y, Tong, Q, Yang, C, Vater, L K, Venkatesh, D, Custeau, T, Chittenden, G, Chinnadurai, H, Gourdeau
Publikováno v: Molecular cancer therapeutics. 1(2)
The Bcl-2 homology 3 (BH3) domain is present in most members of the Bcl-2 protein family and is required to confer the death-inducing properties of pro-apoptotic members, including Bax, Bak, Bad, and Bik, in cell-based assay systems. To determine whe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ad4d962e9693de9bbf22dae57ac393e
https://pubmed.ncbi.nlm.nih.gov/12467227
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3
Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines
Autor: H, Gourdeau, M L, Clarke, F, Ouellet, D, Mowles, M, Selner, A, Richard, N, Lee, J R, Mackey, J D, Young, J, Jolivet, R G, Lafrenière, C E, Cass
Publikováno v: Cancer research. 61(19)
Troxacitabine (Troxatyl; BCH-4556; (-)-2'-deoxy-3'-oxacytidine), a deoxycytidine analogue with an unusual dioxolane structure and nonnatural L-configuration, has potent antitumor activity in animal models and is in clinical trials against human malig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa015b254b008a40d7e0d4a597b8f1bf
https://pubmed.ncbi.nlm.nih.gov/11585758
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4
Anti-Human Immunodeficiency Virus Type 1 Activity, Intracellular Metabolism, and Pharmacokinetic Evaluation of 2′-Deoxy-3′-Oxa-4′-Thiocytidine
Autor: Robert F. Rando, C Locas, J. M. de Muys, Nghe Nguyen-Ba, P S Ahmed, H Gourdeau, Debra L. Taylor, Mark A. Wainberg, Nathalie Richard, Tarek S. Mansour
The racemic nucleoside analogue 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC) is in clinical development for the treatment of human immunodeficiency virus (HIV) type 1 (HIV-1) infection. dOTC is structurally related to lamivudine (3TC), but the oxygen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f53a55bf6eeb183aeadcc541bb47d8
https://europepmc.org/articles/PMC89378/
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7
Modulation of apoptosis by oncogenes
Autor: P. R. Walker, U. Armato, N. Marceau, L. Testolin, M. Sikorska, H. Gourdeau
Publikováno v: Apoptosis in Hormone-Dependent Cancers ISBN: 9783662031247
Apoptosis is a physiological pathway by which tissues eliminate unwanted cells. As far as we know every cell possesses the capability to undergo this form of cellular suicide, but since only a few cells actually do undergo apoptosis the pathway must
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070faa43ccbb429526b388a6f98b1846
http://hdl.handle.net/11562/239424
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9
Relationship between apoptosis and the cell cycle in lymphocytes: roles of protein kinase C, tyrosine phosphorylation, and AP1
Autor: J LeBlanc, J Kwast-Welfeld, Marianna Sikorska, Neugebauer W, H. Gourdeau, P R Walker
Publikováno v: Experimental cell research. 207(1)
The mechanism of switching between the cell cycle and active cell death (apoptosis) was investigated in cytokine-dependent CTLL cells. These cells proliferate in the presence of interleukin 2 (IL2), but accumulate in early G1 and undergo apoptosis in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9deff157848b3ef8797736eae81e5206
https://pubmed.ncbi.nlm.nih.gov/8319766
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10
Down-regulation of cytokeratin 14 mRNA in polyoma virus middle T-transformed rat liver epithelial cells
Autor: I, Royal, H, Gourdeau, R, Blouin, N, Marceau
Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 3(9)
We have recently shown that rat liver nonparenchymal epithelial cells, such as T51B cells, selectively express cytokeratin (CK) 14 as a partner of CK8 in their intermediate filaments, and we proposed CK14 as a unique cell lineage marker of the liver
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75c99ebd79b13f207d138820ede3e8cf
https://pubmed.ncbi.nlm.nih.gov/1384655
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