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of 312
pro vyhledávání: '"H, Gough"'
Autor:
Kristy Kikly, Howard Barff Broughton, William Chang, Selma Sapmaz, Richard Morphy, Holly A. Bina, Jim D. Durbin, Sherry Y Guo, Timothy Ivo Richardson, Jimmy P Steele, Ryan Edward Stites, Brian G. Getman, Vaught Grant Matthews, Veavi Ching-Yun Chang, Pamela K. Shetler, Greg L Durst, Denise D Edmondson, Rob Barr, Helene Rudyk, Charles Willis Lugar, Nita J. Patel, Christian Alexander Clarke, Kelly Wayne Furness, Nicole E New, David K. Clawson, Keith R. Stayrook, Mark Chambers, Brian Michael Mathes, Stephanie L. Stout, Wendy H. Gough
Publikováno v:
Journal of Medicinal Chemistry. 64:5470-5484
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
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Autor:
S. D. Rakotomalala, I. Grant, S. J. Ward, C. Thompson, H. Gough, M. E. Corral, C. J. Laskai, C. Chell
Publikováno v:
International Journal of Primatology. 41:562-565
Autor:
Beverly L Falcon, Michelle Swearingen, Wendy H Gough, Linda Lee, Robert Foreman, Mark Uhlik, Jeff C Hanson, Jonathan A Lee, Don B McClure, Sudhakar Chintharlapalli
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106901 (2014)
Vascular endothelial growth factor (VEGF) plays a dominant role in angiogenesis. While inhibitors of the VEGF pathway are approved for the treatment of a number of tumor types, the effectiveness is limited and evasive resistance is common. One mechan
Externí odkaz:
https://doaj.org/article/da954fc5fdb943c6baa8aa37fcd78d65
Autor:
Albert H Gough, Ning Chen, Tong Ying Shun, Timothy R Lezon, Robert C Boltz, Celeste E Reese, Jacob Wagner, Lawrence A Vernetti, Jennifer R Grandis, Adrian V Lee, Andrew M Stern, Mark E Schurdak, D Lansing Taylor
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102678 (2014)
One of the greatest challenges in biomedical research, drug discovery and diagnostics is understanding how seemingly identical cells can respond differently to perturbagens including drugs for disease treatment. Although heterogeneity has become an a
Externí odkaz:
https://doaj.org/article/073440165ed34f8b8cced8d70b8f685a
Autor:
Charles W, Lugar, Christian A, Clarke, Richard, Morphy, Helene, Rudyk, Selma, Sapmaz, Ryan E, Stites, Grant M, Vaught, Kelly, Furness, Howard B, Broughton, Greg L, Durst, David K, Clawson, Stephanie L, Stout, Sherry Y, Guo, Jim D, Durbin, Keith R, Stayrook, Denise D, Edmondson, Kristy, Kikly, Nicole E, New, Holly A, Bina, Mark G, Chambers, Pamela, Shetler, William Y, Chang, Veavi Ching-Yun, Chang, Rob, Barr, Wendy H, Gough, Jimmy P, Steele, Brian, Getman, Nita, Patel, Brian M, Mathes, Timothy I, Richardson
Publikováno v:
Journal of medicinal chemistry. 64(9)
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Publikováno v:
Journal of food protection. 58(3)
The ability of lactic cultures to grow on Petrifilm
Autor:
L. Pearson, Joanne L. C. Tan, Renate E. Le Marsney, Tracey A. O'Brien, Jerry D. Gibson, Steven Tran, A. Dodds, Gillian Huang, M. Scoyne, R.E. Le Marsney, Simon Durrant, I. Nivison-Smith, M. Greenwood, Mark Hertzberg, Ian Bilmon, Kylie D. Mason, Leonie Wilcox, Donna Aarons, C. To, Andrew Spencer, Catherine H. Cole, Benjamin Daniels, Jenny Muirhead, H. Gough, Heather Tapp, S. Buffery, Chris Fraser, Adam S. Nelson, L. Wilcox, Cecilia Oswald, Anthony J. Dodds, T. O'Brien, L. Ashton, Nicola H. Green, Paul Cannell, Peter J. Shaw, Jeff Szer, K. Rowland, J. Seljak, Ian D. Lewis, Karin Tiedemann, Claire M. Vajdic, C. Vajdic, Anne Maree Johnston, M. Forbes, R Western, Ian Nivison-Smith, Eleni Mayson, Lesley J. Ashton
Publikováno v:
Biology of Blood and Marrow Transplantation. 22:949-956
We quantified the risk of second cancer and late mortality in a population-based Australian cohort of 3273 adult (≥15 years) allogeneic hematopoietic stem cell transplant recipients (1992 to 2007). Most recipients received nonradiation-based condit
Autor:
N. Eckers, L. Grabenhenrich, null D.McBride, H. Gough, A. Reich, L. Rosenfeld, B. Niggemann, S. Siegert, Ö. Aksünger, M. Wjst, M. Kulig, K. Beyer, T. Keil
Publikováno v:
Allergologie. 38:507-515
Autor:
Yao-Chang Xu, Brian Michael Mathes, John Mehnert Schaus, Qi Chen, Maria-Jesus Blanco, Suzanne E. Nutter, David L. Nelson, Deanna Piatt Zacherl, Sidney Xi Liang, Sandra Ann Filla, Wendy H. Gough, Cohen Michael Philip, Kevin John Hudziak, Bai-Ping Ying, Deyi Zhang, Joseph H. Krushinski, Daniel Timothy Kohlman, Frantz Victor, David B. Wainscott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4337-4341
Preclinical experiments and clinical observations suggest the potential effectiveness of selective 5-HT1F receptor agonists in migraine. Identifying compounds with enhanced selectivity is crucial to assess its therapeutic value. Replacement of the in