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Akademický článek

Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?

Autor: Mark H. Kaplan, Rafael Contreras-Galindo, Evelyn Jiagge, Sofia D. Merajver, Lisa Newman, Galya Bigman, Michael H. Dosik, Ganesh S. Palapattu, Javed Siddiqui, Arul M. Chinnaiyan, Sally Adebamowo, Clement Adebamowo

Publikováno v: Infectious Agents and Cancer, Vol 15, Iss 1, Pp 1-15 (2020)

Abstract The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people. We used PCR technology to se

Externí odkaz: https://doaj.org/article/91f29a5b675b4bf4a266d275ede02f19

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Akademický článek

Structural variation of centromeric endogenous retroviruses in human populations and their impact on cutaneous T-cell lymphoma, Sézary syndrome, and HIV infection

Autor: Mark H. Kaplan, Mark Kaminski, Judith M. Estes, Scott D. Gitlin, Joseph Zahn, James T. Elder, Trilokraj Tejasvi, Elizabeth Gensterblum, Amr H. Sawalha, Joseph Patrick McGowan, Michael H. Dosik, Haner Direskeneli, Guher Saruhan Direskeneli, Sally N. Adebamowo, Clement A. Adebamowo, Mohammad Sajadi, Rafael Contreras-Galindo

Publikováno v: BMC Medical Genomics, Vol 12, Iss 1, Pp 1-18 (2019)

Abstract Background Human Endogenous Retroviruses type K HML-2 (HK2) are integrated into 117 or more areas of human chromosomal arms while two newly discovered HK2 proviruses, K111 and K222, spread extensively in pericentromeric regions, are the firs

Externí odkaz: https://doaj.org/article/66f9263a639348f29d3f0aa69955e37f

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Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?

Autor: Sofia D. Merajver, Javed Siddiqui, Michael H. Dosik, Lisa A. Newman, Galya Bigman, Ganesh S. Palapattu, Rafael Contreras-Galindo, Clement Adebamowo, Mark H. Kaplan, Arul M. Chinnaiyan, Evelyn Jiagge, Sally N. Adebamowo

Publikováno v: Infectious Agents and Cancer, Vol 15, Iss 1, Pp 1-15 (2020)
Infectious Agents and Cancer

The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people. We used PCR technology to search for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d852b56ce64a1f3d26078c58947d109c
http://link.springer.com/article/10.1186/s13027-020-00284-w

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Structural variation of centromeric endogenous retroviruses in human populations and their impact on cutaneous T-cell lymphoma, Sezary syndrome, and HIV infection

Autor: Joseph Zahn, Sally N. Adebamowo, Amr H. Sawalha, James T. Elder, Rafael Contreras-Galindo, Judith Estes, Mohammad M. Sajadi, Elizabeth Gensterblum, Haner Direskeneli, Mark S. Kaminski, Mark H. Kaplan, Scott D. Gitlin, Clement Adebamowo, Michael H. Dosik, Trilokraj Tejasvi, Guher Saruhan Direskeneli, Joseph P. McGowan

Publikováno v: BMC Medical Genomics
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-18 (2019)

Background Human Endogenous Retroviruses type K HML-2 (HK2) are integrated into 117 or more areas of human chromosomal arms while two newly discovered HK2 proviruses, K111 and K222, spread extensively in pericentromeric regions, are the first retrovi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943287848ec3502d9eee63c44aad4930
https://hdl.handle.net/11424/243994

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Partially Unspliced and Fully Spliced ELF3 mRNA, Including a New Alu Element in Human Breast Cancer

Autor: Mark H. Kaplan, Xue Ping Wang, Hao Peng Xu, Michael H. Dosik

Publikováno v: Breast Cancer Research and Treatment. 83:171-187

Using modified representational difference analysis, a DNA fragment (GC3) was isolated as a difference between a breast cancer and a normal cell line from the same patient. GC3 proved to be a fragment of intron 7 of the ELF3 gene, an ets family trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b93dc9767d0b69ac58cdcf68eac0708
https://doi.org/10.1023/b:brea.0000010710.51614.2d

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Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals

Autor: Mark H. Kaplan, Yasuhiro Yamamura, Michael H. Dosik, David M. Markovitz, Fabiola Giusti, Eric Lorenzo, Marta J. Gonzalez-Hernandez, Angie C. Contreras-Galindo, Ilaria Ferlenghi, Rafael Contreras-Galindo, Scott D. Gitlin

We previously reported finding the RNA of a type K human endogenous retrovirus, HERV-K (HML-2), at high titers in the plasma of HIV-1-infected and cancer patients (R. Contreras-Galindo et al., J. Virol. 82:9329–9236, 2008.). The extent to which the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dfa936abb193806cb6199882507310
https://europepmc.org/articles/PMC3255917/

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Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer

Autor: Daniel F. Hayes, Thibault Verjat, Michael H. Dosik, Fabio Bagnoli, Fabiola Giusti, David M. Markovitz, Mark H. Kaplan, Scott D. Gitlin, Rafael Contreras-Galindo, Philippe Leissner, Ilaria Ferlenghi

Publikováno v: Journal of virology. 82(19)

Actively replicating endogenous retroviruses entered the human genome millions of years ago and became a stable part of the inherited genetic material. They subsequently acquired multiple mutations, leading to the assumption that these viruses no lon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00401a2e0d7b785cd170ac681ac60625
https://pubmed.ncbi.nlm.nih.gov/18632860

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A study of adult T-cell leukemia/lymphoma incidence in central Brooklyn

Autor: P H, Levine, H, Dosik, E M, Joseph, S, Felton, M A, Bertoni, J, Cervantes, V, Moulana, A B, Miotti, L J, Goberdhan, S L, Lee, A, Daouad, M, DaCosta, E S, Jaffe, C A, Axiotis, F R, Cleghorn, A, Kahn, S L, Welles

Publikováno v: International journal of cancer. 80(5)

Adult T-cell leukemia/lymphoma (ATL), a rare outcome of infection with human T-lymphotropic virus (HTLV-I), is endemic in central Brooklyn, which has a large Caribbean migrant population. Previous studies have suggested that HTLV-I prevalence in cent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29be5f0cc7d8f9ec48626fa938c2f59a
https://pubmed.ncbi.nlm.nih.gov/10048963

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Chronic hepatitis C in patients with sickle cell disease

Autor: M F, Hasan, F, Marsh, G, Posner, R, Bellevue, H, Dosik, R, Suatengco, N, Ramani

Publikováno v: The American journal of gastroenterology. 91(6)

To determine the prevalence of hepatitis C virus (HCV) antibody in patients with sickle cell disease and to analyze the nature of chronic liver disease in these patients.A total of 99 patients attending a comprehensive sickle cell and thalassemia pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28da95af92cf77f9caeb8622c58f9f9c
https://pubmed.ncbi.nlm.nih.gov/8651171

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