Zobrazeno 1 - 10
of 475
pro vyhledávání: '"H, DYER"'
Autor:
Adam H. Dyer, Helena Dolphin, Antoinette O’Connor, Laura Morrison, Gavin Sedgwick, Conor Young, Emily Killeen, Conal Gallagher, Aoife McFeely, Eimear Connolly, Naomi Davey, Paul Claffey, Paddy Doyle, Shane Lyons, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O’Farrelly, Aoife Fallon, Sean O’Dowd, Nollaig M. Bourke, Sean P. Kennelly
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Plasma p-tau217 has emerged as the most promising blood-based marker (BBM) for the detection of Alzheimer Disease (AD) pathology, yet few studies have evaluated plasma p-tau217 performance in memory clinic settings. We examined th
Externí odkaz:
https://doaj.org/article/0e00f717357c41d39551a030163c489b
Autor:
Laura Morrison, Adam H. Dyer, Helena Dolphin, Isabella Batten, Conor Reddy, Matthew Widdowson, Conor P. Woods, James Gibney, Nollaig M. Bourke, Sean P. Kennelly
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 41, Iss , Pp 100862- (2024)
Midlife cardiovascular risk factors such as Type 2 Diabetes (T2DM) and obesity are associated with the later development of cognitive impairment and dementia. Systemic inflammation is postulated as a crucial mechanism, yet there are few studies exami
Externí odkaz:
https://doaj.org/article/f8306b991c3b4f9d803209c20cf33e90
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Over 55 million adults are living with dementia globally, which is projected to reach 157 million by 2050. Mild cognitive impairment (MCI), a syndrome of memory impairment with intact activities of daily living, may precede dement
Externí odkaz:
https://doaj.org/article/bbb019cecba14b0780e0ccba6136d92f
Autor:
Laura Morrison, Adam H. Dyer, Helena Dolphin, Isabelle Killane, Nollaig M. Bourke, Matthew Widdowson, Conor P. Woods, James Gibney, Richard B. Reilly, Sean P. Kennelly
Publikováno v:
Sensors, Vol 24, Iss 12, p 3903 (2024)
Midlife risk factors such as type 2 diabetes mellitus (T2DM) confer a significantly increased risk of cognitive impairment in later life with executive function, memory, and attention domains often affected first. Spatiotemporal gait characteristics
Externí odkaz:
https://doaj.org/article/16cf272cc77e44509db8c53eb78b646e
Autor:
Eimear Connolly, Shane Lyons, Cliona O’Farrelly, Graham Knight, Antoinette O’Connor, Adam H Dyer, Sean P Kennelly, Emily Killeen, Christine Gaffney, Helena Dolphin, Laura Morrison, Gavin Sedgwick, Aoife McFeely, Conal Gallagher, Naomi Davey, Conor Young, Ruth Ennis, Cathy McHale, Jasmine Joseph, Emmet Kelly, Nollaig M Bourke, Aoife Fallon, Sean O’Dowd
Publikováno v:
BMJ Open, Vol 13, Iss 12 (2023)
Introduction Alzheimer’s disease and other dementias affect >50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the understanding
Externí odkaz:
https://doaj.org/article/0170f17c49d84fd19fc343b814ad8a68
Autor:
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O’Dowd, Laura O’Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O’Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Clinical outcomes from infection with SARS-CoV-2, the cause of the COVID-19 pandemic, are remarkably variable ranging from asymptomatic infection to severe pneumonia and death. One of the key drivers of this variability is differing trajectories in t
Externí odkaz:
https://doaj.org/article/55a248964b0f4c47b23b9c07a22af0be
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285529 (2023)
BackgroundIn addition to the clear cardiovascular benefit, there has been renewed interest in the potential of statins in the prevention of cognitive impairment and dementia in older adults. However, whether ongoing statin use can delay cognitive dec
Externí odkaz:
https://doaj.org/article/b2bd3f353dac4d388c9970b0e35d7bb9
Autor:
Adam H. Dyer, Isabella Batten, Conor Reddy, Liam Townsend, Conor P. Woods, Desmond O’Neill, James Gibney, Sean P. Kennelly, Nollaig M. Bourke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Midlife Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of Alzheimer Disease (AD) in later life, with altered inflammatory responses postulated as key pathological drivers. Previous studies have demonstrated increased responsiven
Externí odkaz:
https://doaj.org/article/b716cd97bc3345c68d0db4d35f84b9ee
Publikováno v:
Geriatrics, Vol 8, Iss 4, p 75 (2023)
Apathy is a complex multi-dimensional syndrome that affects up to 70% of individuals with Alzheimer’s disease (AD). Whilst many frameworks to define apathy in AD exist, most include loss of motivation or goal-directed behaviour as the central featu
Externí odkaz:
https://doaj.org/article/5089c1c37bde4f7daa3104ef10f41288
Autor:
Liam Townsend, Adam H. Dyer, Aifric Naughton, Sultan Imangaliyev, Jean Dunne, Rachel Kiersey, Dean Holden, Aoife Mooney, Deirdre Leavy, Katie Ridge, Jamie Sugrue, Mubarak Aldoseri, Jo Hannah Kelliher, Martina Hennessy, Declan Byrne, Paul Browne, Christopher L. Bacon, Catriona Doyle, Ruth O’Riordan, Anne-Marie McLaughlin, Ciaran Bannan, Ignacio Martin-Loeches, Arthur White, Rachel M. McLoughlin, Colm Bergin, Nollaig M. Bourke, Cliona O’Farrelly, Niall Conlon, Clíona Ní Cheallaigh
Publikováno v:
Heliyon, Vol 8, Iss 4, Pp e09230- (2022)
SARS-CoV-2 infection causes a wide spectrum of disease severity. Identifying the immunological characteristics of severe disease and the risk factors for their development are important in the management of COVID-19. This study aimed to identify and
Externí odkaz:
https://doaj.org/article/2042931142d64da28927de464f03535e