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Akademický článek

Effect of cyclo-oxygenase inhibitor use during checkpoint blockade immunotherapy in patients with metastatic melanoma and non-small cell lung cancer

Autor: Janice M Mehnert, Shang-Jui Wang, Karishma Khullar, Sinae Kim, Nikhil Yegya-Raman, Samuel H Crayton, John L Nosher, Michael A Gentile, Salma K Jabbour

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background Immune checkpoint inhibitors (ICIs) improve survival outcomes in metastatic melanoma and non-small cell lung cancer (NSCLC). Preclinical evidence suggests that overexpression of cyclo-oxygenase-2 (COX2) in tumors facilitates immune evasion

Externí odkaz: https://doaj.org/article/9b8f771430a647aebea7f7b8c4dfb698

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Akademický článek

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Replaced right and common hepatic arteries with lienogastric trunk: a rare variant of celiaco-mesenteric anatomy

Autor: John L. Nosher, Gregg Khodorov, Samuel H Crayton, Miral S. Grandhi, Leonard J. Bodner

Publikováno v: Surgical and Radiologic Anatomy. 42:1475-1477

We report a rare variant in mesenteric arterial anatomy: replacement of the right hepatic and common hepatic arteries to the SMA in a patient treated for hepatocellular carcinoma. The potential clinical implications of this unusual variation of celia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a1a465d64826fb72839295f821afb0
https://doi.org/10.1007/s00276-020-02505-8

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Effect of cyclo-oxygenase inhibitor use during checkpoint blockade immunotherapy in patients with metastatic melanoma and non-small cell lung cancer

Autor: Karishma Khullar, Roman Groisberg, Shang-Jui Wang, Sinae Kim, Samuel H Crayton, Salma K. Jabbour, Nikhil Yegya-Raman, John L. Nosher, Jyoti Malhotra, Michael A. Gentile, Janice M. Mehnert, Ann W. Silk

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer

BackgroundImmune checkpoint inhibitors (ICIs) improve survival outcomes in metastatic melanoma and non-small cell lung cancer (NSCLC). Preclinical evidence suggests that overexpression of cyclo-oxygenase-2 (COX2) in tumors facilitates immune evasion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b33af2a7e440a7f19501c582a9b9f06
https://jitc.bmj.com/content/8/2/e000889.full

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Akademický článek

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Cyclooxygenase inhibitor use during checkpoint immunotherapy and effect on time to progression and overall survival for metastatic melanoma and non-small cell lung cancer patients

Autor: Karishma Khullar, Jyoti Malhotra, Michael A. Gentile, Nikhil Yegya-Raman, Roman Groisberg, Shang-Jui Wang, Ann W. Silk, John L. Nosher, Janice M. Mehnert, Salma K. Jabbour, Sinae Kim, Samuel H Crayton

Publikováno v: Journal of Clinical Oncology. 38:e22034-e22034

e22034 Background: Immune checkpoint inhibitors (ICIs) improve survival outcomes in metastatic melanoma and non-small cell lung cancer (NSCLC). Preclinical evidence suggests that overexpression of cyclooxygenase-2 (COX2) in tumors facilitates immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76f3c94698a7bfa4140cf6b0c1666124
https://doi.org/10.1200/jco.2020.38.15_suppl.e22034

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Akademický článek

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A pH-Responsive Drug-Delivery Platform Based on Glycol Chitosan–Coated Liposomes

Autor: Lesan Yan, Ahmad Amirshaghaghi, Samuel H. Crayton, Zhiliang Cheng, Andrew Tsourkas, Jayesh P. Thawani

Currently, a substantial amount of effort is focused on developing actively targeted, receptor-specific nanoparticles for the delivery of anticancer drugs and diagnostic imaging contrast agents.[1–7] Receptor-targeted nanoparticles hold much promis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8ce4eff8f373b4e519d920078e4ac6
https://europepmc.org/articles/PMC4592472/

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Akademický článek

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Quantitative Comparison of Tumor Delivery for Multiple Targeted Nanoparticles Simultaneously by Multiplex ICP-MS

Autor: Andrew Elias, Robert Warden-Rothman, Samuel H. Crayton, Andrew Tsourkas

Publikováno v: Scientific Reports

Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and expense of animal testing often makes it unfeasible to examine this large n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9829317097f58a5b0b6ab4304706a7eb
http://europepmc.org/articles/PMC4894420

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