Zobrazeno 1 - 10
of 282
pro vyhledávání: '"H, Brehm"'
Autor:
Afam A Okoye, Rémi Fromentin, Hiroshi Takata, Jessica H Brehm, Yoshinori Fukazawa, Bryan Randall, Marion Pardons, Vincent Tai, Jun Tang, Jeremy Smedley, Michael Axthelm, Jeffrey D Lifson, Louis J Picker, David Favre, Lydie Trautmann, Nicolas Chomont
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010245 (2022)
Activation of the NF-κB signaling pathway by Protein Kinase C (PKC) agonists is a potent mechanism for human immunodeficiency virus (HIV) latency disruption in vitro. However, significant toxicity risks and the lack of evidence supporting their acti
Externí odkaz:
https://doaj.org/article/010dc74613b6426081cb5b18f4918266
Autor:
Francesco Andrea Procopio, Rémi Fromentin, Deanna A. Kulpa, Jessica H. Brehm, Anne-Gaelle Bebin, Matthew C. Strain, Douglas D. Richman, Una O'Doherty, Sarah Palmer, Frederick M. Hecht, Rebecca Hoh, Richard J.O. Barnard, Michael D. Miller, Daria J. Hazuda, Steven G. Deeks, Rafick-Pierre Sékaly, Nicolas Chomont
Publikováno v:
EBioMedicine, Vol 2, Iss 8, Pp 874-883 (2015)
Background: Quantifying latently infected cells is critical to evaluate the efficacy of therapeutic strategies aimed at reducing the size of the long-lived viral reservoir, but the low frequency of these cells makes this very challenging. Methods: We
Externí odkaz:
https://doaj.org/article/2e7bfa284a9f4d7b88f06a8f37a05e38
Autor:
Christina Gavegnano, Jessica H Brehm, Franck P Dupuy, Aarthi Talla, Susan Pereira Ribeiro, Deanna A Kulpa, Cheryl Cameron, Stephanie Santos, Selwyn J Hurwitz, Vincent C Marconi, Jean-Pierre Routy, Laurent Sabbagh, Raymond F Schinazi, Rafick Pierre Sékaly
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006740 (2017)
Despite advances in the treatment of HIV infection with ART, elucidating strategies to overcome HIV persistence, including blockade of viral reservoir establishment, maintenance, and expansion, remains a challenge. T cell homeostasis is a major drive
Externí odkaz:
https://doaj.org/article/4317a5f5021746d493577bcfb4b68481
Autor:
Cornelia Fink, Roswitha Weigel, Tanja Hembes, Heidrun Lauke-Wettwer, Sabine Kliesch, Martin Bergmann, Ralph H. Brehm
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 12, Pp 1019-1027 (2006)
Carcinoma in situ (CIS) is the noninvasive precursor of most human testicular germ cell tumors. In normal seminiferous epithelium, specialized tight junctions between Sertoli cells constitute the major component of the blood-testis barrier. Sertoli c
Externí odkaz:
https://doaj.org/article/a8d97bf8b0a44f6d9ce6cf164f78dadb
Autor:
Susan Pereira Ribeiro, Daniel Lamarre, Peter W. Hunt, Carey L. Shive, Andrey Loboda, Aarthi Talla, Jeffery Ahlers, Xuan Xu, Benigno Rodriguez, Deanna A. Kulpa, Razvan Cristescu, Khader Ghneim, Slim Fourati, Robert S. Balderas, Steven G. Deeks, Rafick Pierre Sekaly, I-Ming Wang, Ashish Sharma, Michael M. Lederman, Daria J. Hazuda, Jessica H. Brehm, Daniel C. Douek
Current therapeutic interventions to eradicate latent HIV (“reservoir”) and restore immune function in ART-treated HIV infection have yet to show efficacy. To explore mechanisms of HIV persistence, we apply an integrated systems biology approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b19b525a9f69b5f7c68117fcbf2b19
https://doi.org/10.21203/rs.3.rs-923015/v1
https://doi.org/10.21203/rs.3.rs-923015/v1
Autor:
Steven G. Deeks, Razvan Cristescu, Peter W. Hunt, Khader Ghneim, I-Ming Wang, Robert S. Balderas, Susan Pereira Ribeiro, Samuel Darko, Sahaana Arumugam, Ali Filali-Mouhim, Rafick-Pierre Sekaly, Daniel Lamarre, Aarthi Talla, Michael M. Lederman, Ashish Sharma, Xuan Xu, Benigno Rodriguez, Daniel C. Douek, Daria J. Hazuda, Jessica H. Brehm, Deanna A. Kulpa, Jeffery Ahlers, Carey L. Shive, Andrey Loboda, Slim Fourati
Publikováno v:
SSRN Electronic Journal.
Therapeutic interventions to eradicate latent HIV in ART-treated infection have yet to show efficacy. We used a systems biology approach to identify a subset of ART-treated individuals with immune-dysfunction that had the highest frequencies of cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be86938b4d65c93bcb04d60eabdbcdb0
https://doi.org/10.2139/ssrn.3822732
https://doi.org/10.2139/ssrn.3822732
Autor:
Steven G. Deeks, Ashish Sharma, Jeffrey D. Ahlers, Xuan Xu, I-Ming Wang, Susan Pereira Ribeiro, Robert S. Balderas, Daria J. Hazuda, Sahaana Arumugam, Jessica H. Brehm, Slim Fourati, Daniel Lamarre, Peter W. Hunt, Rafick-Pierre Sekaly, Benigno Rodriguez, Carey L. Shive, Deanna A. Kulpa, Andrey Loboda, Samuel Darko, Aarthi Talla, Michael M. Lederman, Razvan Cristescu, Daniel C. Douek, Khader Ghneim
SummaryCurrent therapeutic interventions to eradicate latent HIV (“reservoir”) and restore immune function in ART-treated HIV infection have yet to show efficacy. To explore mechanisms of HIV persistence, we apply an integrated systems biology ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::715c4ad54f766f272222dd67fc1de346
https://doi.org/10.1101/2020.12.15.422949
https://doi.org/10.1101/2020.12.15.422949
Autor:
Jessica H Brehm, Yanille Scott, Dianna L Koontz, Steven Perry, Scott Hammer, David Katzenstein, John W Mellors, Nicolas Sluis-Cremer, AIDS Clinical Trials Group Study 175 Protocol Team
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31558 (2012)
We previously demonstrated in vitro that zidovudine (AZT) selects for A371V in the connection domain and Q509L in ribonuclease H (RNase H) domain of HIV-1 reverse transcriptase (RT) which, together with the thymidine analog mutations D67N, K70R and T
Externí odkaz:
https://doaj.org/article/2497f1f45d12458f846a0e6201dafc35
Autor:
Steven E. Bosinger, Gavin C. Sampey, Zhang Wang, Jean-Pierre Routy, Robert G. Ferris, Rae Ann Spagnuolo, Edward P. Browne, Brandon F. Keele, Greg K. Tharp, Christopher C. Nixon, Nils Schoof, Christine M. Fennessey, Chandrav De, Corinne G. Cammon, Rachel A. Cleary, David Favre, Nancie M. Archin, J. Victor Garcia, Jennifer Deutsch, Angela Wahl, Sean Maguire, Hasse Walum, Thomas H. Vanderford, Cameron Mattingly, David M. Margolis, Baolin Liao, Nathaniel J. Schramm, Richard M. Dunham, Amit A. Upadhyay, Jessica H. Brehm, Cristin M. Galardi, Saintedym Wills, Corbin D. Jones, Maud Mavigner, Sherrie Jean, Jeffrey D. Lifson, Matt Kanke, Guido Silvestri, Phong T. Ho, Alyssa D. Brooks, Ann Chahroudi, David M. Irlbeck, Shane D. Falcinelli
Publikováno v:
Nature
Long-lasting, latently infected resting CD4+ T cells are the greatest obstacle to obtaining a cure for HIV infection, as these cells can persist despite decades of treatment with antiretroviral therapy (ART). Estimates indicate that more than 70 year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12de8e37415a35a7eda62c90a149d687
https://doi.org/10.1038/s41577-020-0283-8
https://doi.org/10.1038/s41577-020-0283-8
Autor:
K. Sholtis, Shane D. Falcinelli, Richard M. Dunham, D. Favre, E. Cule, Ferris Rg, M. Kanke, Corbin D. Jones, Brigitte Allard, S. Wills, J. Kircherr, Jean-Pierre Routy, Erin Stuelke, Edward P. Browne, D. Margolis, Z. Wang, Jessica H. Brehm, David M. Irlbeck, G.C. Sampey, Nancie M. Archin
Publikováno v:
Journal of Virus Eradication, Vol 5, Iss, Pp 14-(2019)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185e20bd5e98758b51c1d4cb32670c9e
http://www.sciencedirect.com/science/article/pii/S2055664020310475
http://www.sciencedirect.com/science/article/pii/S2055664020310475