Zobrazeno 1 - 10
of 487
pro vyhledávání: '"H, Beier"'
Autor:
Massimo Martinelli, Gabrielle Aguilar, David S.M. Lee, Andrew Kromer, Nhu Nguyen, Benjamin J. Wilkins, Tatiana Akimova, Ulf H. Beier, Louis R. Ghanem
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105860- (2023)
Summary: The RNA-binding protein Pcbp2 is widely expressed in the innate and adaptive immune systems and is essential for mouse development. To determine whether Pcbp2 is required for CD4+ T cell development and function, we derived mice with conditi
Externí odkaz:
https://doaj.org/article/abe9b38a417741fba48e88fa11136c14
Autor:
David D. Aufhauser, Paul Hernandez, Seth J. Concors, Ciaran O’Brien, Zhonglin Wang, Douglas R. Murken, Arabinda Samanta, Ulf H. Beier, Lauren Krumeich, Tricia R. Bhatti, Yanfeng Wang, Guanghui Ge, Liqing Wang, Shayan Cheraghlou, Florence F. Wagner, Edward B. Holson, Jay H. Kalin, Philip A. Cole, Wayne W. Hancock, Matthew H. Levine
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Histone/protein deacetylases (HDAC) 1 and 2 are typically viewed as structurally and functionally similar enzymes present within various co-regulatory complexes. We tested differential effects of these isoforms in renal ischemia reperfusion
Externí odkaz:
https://doaj.org/article/86bec5fc8fee49dbbb68530f910709b1
Autor:
Peter J. Siska, Jing Jiao, Carina Matos, Katrin Singer, Raffaela S. Berger, Katja Dettmer, Peter J. Oefner, Michelle D. Cully, Zhonglin Wang, William J. QuinnIII, Kristen N. Oliff, Benjamin J. Wilkins, Lanette M. Christensen, Liqing Wang, Wayne W. Hancock, Joseph A. Baur, Matthew H. Levine, Ines Ugele, Roman Mayr, Kathrin Renner, Liang Zhou, Marina Kreutz, Ulf H. Beier
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103734- (2021)
Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce le
Externí odkaz:
https://doaj.org/article/707b3408191f474680381251d1043115
Autor:
Priya Khurana, Chakkapong Burudpakdee, Stephan A. Grupp, Ulf H. Beier, David M. Barrett, Hamid Bassiri
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Invariant natural killer T (iNKT) cells comprise a unique subset of lymphocytes that are primed for activation and possess innate NK-like functional features. Currently, iNKT cell-based immunotherapies remain in early clinical stages, and little is k
Externí odkaz:
https://doaj.org/article/cba694a0cd1e44b5a960cff9055f4538
Autor:
Eros Di Giorgio, Liqing Wang, Yan Xiong, Lanette M. Christensen, Tatiana Akimova, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Claudio Brancolini, Ulf H. Beier, Wayne W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The Mads/Mef2 (Mef2a/b/c/d) family of transcription factors (TFs) regulates differentiation of muscle cells, neurons and hematopoietic cells. By functioning in physiological feedback loops, Mef2 TFs promote the transcription of their repressor, Hdac9
Externí odkaz:
https://doaj.org/article/84b9b8c42c964606b0b0ab25953d1600
Autor:
William J. Quinn, III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108500- (2020)
Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effe
Externí odkaz:
https://doaj.org/article/7bafd43031934dc89425250de8164ad0
Publikováno v:
Acta Otorhinolaryngologica Italica, Vol 38, Iss 4, Pp 316-322 (2018)
Externí odkaz:
https://doaj.org/article/269a349288374b87b345bcb86c568713
Autor:
Jianbing Huang, Liqing Wang, Satinder Dahiya, Ulf H. Beier, Rongxiang Han, Arabinda Samanta, Joel Bergman, Eduardo M. Sotomayor, Edward Seto, Alan P. Kozikowski, Wayne W. Hancock
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Current interest in Foxp3+ T-regulatory (Treg) cells as therapeutic targets in transplantation is largely focused on their harvesting pre-transplant, expansion and infusion post-transplantation. An alternate strategy of pharmacologic modulat
Externí odkaz:
https://doaj.org/article/5a235acd97ca4a28899dd27f87d82b68
Autor:
Liqing Wang, Suresh Kumar, Satinder Dahiya, Feng Wang, Jian Wu, Kheng Newick, Rongxiang Han, Arabinda Samanta, Ulf H. Beier, Tatiana Akimova, Tricia R. Bhatti, Benjamin Nicholson, Mathew P. Kodrasov, Saket Agarwal, David E. Sterner, Wei Gu, Joseph Weinstock, Tauseef R. Butt, Steven M. Albelda, Wayne W. Hancock
Publikováno v:
EBioMedicine, Vol 13, Iss C, Pp 99-112 (2016)
Foxp3+ T-regulatory (Treg) cells are known to suppress protective host immune responses to a wide variety of solid tumors, but their therapeutic targeting is largely restricted to their transient depletion or “secondary” modulation, e.g. using an
Externí odkaz:
https://doaj.org/article/11bbaeb8902a4226b1f3c2291eaa0058
Autor:
Wayne W. Hancock, Michaela R. Anderson, Edward Cantu, David J. Lederer, Tatiana Akimova, Isaac E Sasson, Lanette M Christensen, David S. Wilkes, Tianyi Zhang, Rongxiang Han, Jing Jiao, Trivikram Gaddapara, Tricia R. Bhatti, Matthew H. Levine, Arabinda Samanta, Zhonglin Wang, Ulf H. Beier, Rebecca A. Simmons, Dmitry Negorev, Liqing Wang, Joshua M. Diamond, Jason D. Christie
Publikováno v:
Am J Respir Crit Care Med
Rationale: Primary graft dysfunction (PGD) is a severe form of acute lung injury, leading to increased early morbidity and mortality after lung transplant. Obesity is a major health problem, and recipient obesity is one of the most significant risk f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7985af3fba8a88729b8729ad769ed2c
https://doi.org/10.1164/rccm.202012-4306oc
https://doi.org/10.1164/rccm.202012-4306oc