Zobrazeno 1 - 10
of 34
pro vyhledávání: '"H, Bedard"'
Autor:
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112488- (2023)
Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl
Externí odkaz:
https://doaj.org/article/12bc2d6551c14f2b8d253e56cdc46fc0
Autor:
Felipe Henriques, Alexander H. Bedard, Adilson Guilherme, Mark Kelly, Jingyi Chi, Peng Zhang, Lawrence M. Lifshitz, Karl Bellvé, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, Lee S. Weinstein, Jiandie D. Lin, Paul Cohen, Michael P. Czech
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107998- (2020)
Summary: Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregul
Externí odkaz:
https://doaj.org/article/54696ef0102c4411a50554f01eb35a76
Autor:
Adilson Guilherme, Batuhan Yenilmez, Alexander H. Bedard, Felipe Henriques, Dianxin Liu, Alexandra Lee, Lauren Goldstein, Mark Kelly, Sarah M. Nicoloro, Min Chen, Lee Weinstein, Sheila Collins, Michael P. Czech
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Here, we show that β adrenergic signaling coordinately upregulates de novo lipogenesis (DNL) and thermogenesis in subcutaneous white adipose tissue (sWAT), and both effects are blocked in mice lacking the cAMP-generating G protein-coupled r
Externí odkaz:
https://doaj.org/article/0137a35610994b6b9548a6615bde2b9e
Autor:
Adilson Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark Kelly, Donald A. Morgan, Kamal Rahmouni, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 116-125 (2018)
Objective: Crosstalk between adipocytes and local neurons may be an important regulatory mechanism to control energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN
Externí odkaz:
https://doaj.org/article/15917499c6d14b8da7c28dcc88f2cde2
Autor:
Kevin Qian, Marcus J. Tol, Jin Wu, Lauren F. Uchiyama, Xu Xiao, Liujuan Cui, Alexander H. Bedard, Thomas A. Weston, Pradeep S. Rajendran, Laurent Vergnes, Yuta Shimanaka, Yesheng Yin, Yasaman Jami-Alahmadi, Whitaker Cohn, Bryce T. Bajar, Chia-Ho Lin, Benita Jin, Laura A. DeNardo, Douglas L. Black, Julian P. Whitelegge, James A. Wohlschlegel, Karen Reue, Kalyanam Shivkumar, Feng-Jung Chen, Stephen G. Young, Peng Li, Peter Tontonoz
Publikováno v:
Nature
Multilocular adipocytes are a hallmark of thermogenic adipose tissue(1,2), but the factors that enforce this cellular phenotype are largely unknown. Here, we show that an adipocyte-selective product of the Clstn3 locus (CLSTN3β) present in only plac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d398f0ffd1d3e335b793aade13ff43e3
https://doi.org/10.1038/s41586-022-05507-1
https://doi.org/10.1038/s41586-022-05507-1
Autor:
Christin Carter-Su, Martin G. Myers, Jr, Ormond A. MacDougald, Gowri Chandrashekar, Erik S. Clutter, Abrielle M. Cacciaglia, Paul B. Vander, Devika P. Bagchi, Alexander H. Bedard, Lauren C. DeSantis, Joel M. Cline, Alan C. Rupp, Anabel Flores, Lawrence S. Argetsinger, Jessica L. Cote, Ada Admin
Mice lacking SH2B1 and humans with inactivating mutations of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the receptors of multiple hormones and neurotrophic factors. Of the four known alternat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a79c3cf7a5184c1d76cfda90893f0213
https://doi.org/10.2337/figshare.13229090.v1
https://doi.org/10.2337/figshare.13229090.v1
Autor:
Martin G. Myers, Joel M. Cline, Erik S. Clutter, Anabel Flores, Lauren C. DeSantis, Alexander H Bedard, Christin Carter-Su, Abrielle M Cacciaglia, Lawrence S. Argetsinger, Jessica L. Cote
Publikováno v:
Journal of the Endocrine Society
The scaffold protein SH2B1 plays a critical role in the regulation of energy balance and glucose homeostasis—humans with mutations in SH2B1 are obese and diabetic, as are SH2B1KO mice. The 4 known isoforms of SH2B1 (α, β, γ, δ), which differ on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a681d5993a1572a0806c3be1a2c6f7
https://doi.org/10.1210/js.2019-or12-6
https://doi.org/10.1210/js.2019-or12-6
Publikováno v:
Nature reviews. Endocrinology. 15(4)
Adipose tissue comprises adipocytes and many other cell types that engage in dynamic crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has been studied for decades, it has been appreciated only in the past 5 yea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44c837241e579099a1c8694ee2cb8d1
https://pubmed.ncbi.nlm.nih.gov/30733616
https://pubmed.ncbi.nlm.nih.gov/30733616
Autor:
Leslie A. Rowland, Yetao Wang, Jingyi Chi, Batuhan Yenilmez, Lawrence M. Lifshitz, Jiandie D. Lin, Lee S. Weinstein, Karl D. Bellve, Mark J. S. Kelly, Felipe Henriques, Alexander H. Bedard, Michael P. Czech, Paul Cohen, Adilson L. Guilherme, Peng Zhang, Jeremy Luban, Shreya Kumar
Publikováno v:
Cell reports
Cell Reports, Vol 32, Iss 5, Pp 107998-(2020)
Cell Reports, Vol 32, Iss 5, Pp 107998-(2020)
SUMMARY Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e432da3dcd1af3eac3aab2402699e8
https://doi.org/10.1016/j.celrep.2020.107998
https://doi.org/10.1016/j.celrep.2020.107998