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Autor: H Bartosz-Bechowski, R Miedzybrodzki, S Szymaniec

Publikováno v: Acta Biochimica Polonica. 48:1155-1158

A series of new nociceptin analogues containing cysteine was tested for their nociceptive effects in tail-flick test on mice after icv injection. The cysteines were introduced in order to get irreversibly binding analogues based on the assumption tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebf776d24ea5400f65fe45dcea9389a4
https://doi.org/10.18388/abp.2001_3883

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Myotropic effects of proctolin analogues, modified in position 2 of the peptide chain, on the foregut of the locust Schistocerca gregaria

Autor: Danuta Konopińska, Jane M. Hinton, H. Bartosz-Bechowski, Richard H. Osborne

Publikováno v: Journal of Insect Physiology. 42:449-454

Proctolin (H.Arg.Tyr.Leu.Pro.Thr.OH) caused dose-dependent contraction of the isolated foregut of the locust Schistocerca gregaria at concentrations ranging from 10 −8 , m to 2 × 10 −6 , m . Of the ten analogues evaluated, [Phe( p -NH 2 ) 2 ]-,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73c1dd15ad30753adee1cb3c1c799512
https://doi.org/10.1016/0022-1910(95)00130-1

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Novel nociceptin analogues

Autor: H, Bartosz-Bechowski, R, Miedzybrodzki, S, Szymaniec

Publikováno v: Acta biochimica Polonica. 48(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::159ced706577939e065d2856bccafe42
https://pubmed.ncbi.nlm.nih.gov/11995984

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Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors

Autor: H, Bartosz-Bechowski, P, Davis, J, Slaninova, E, Malatynska, D, Stropova, F, Porreca, H I, Yamamura, V J, Hruby

Publikováno v: The journal of peptide research : official journal of the American Peptide Society. 53(3)

We report here on the binding affinity and bioassay results of cyclic enkephalin analogs comprising a cyclic moiety and C-terminal fragment of MERGL, where ME denotes methionine enkephalin. MERGL (YGGFMRGL) has been suggested to be cleaved enzymatica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::699e2f14fb5c50be1bfddbb012878ad1
https://pubmed.ncbi.nlm.nih.gov/10231722

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Insect neuropeptide leucopyrokinin analogues--synthesis and antinociceptive effect in rats

Autor: A, Plech, M, Rykaczewska-Czerwińska, H, Bartosz-Bechowski, D, Lombarska-Sliwińska, M, Małota, M, Szewczyk, R, Brus, D, Konopińska

Publikováno v: Polish journal of pharmacology. 49(2-3)

The insect myotropic octapeptide leucopyrokinin Glp-Thr-Ser-Phe-Thr-Pro-Arg-Leu-amide (LPK or Lem-PK) (1) and its truncated analogues without the first N-terminal amino acids [2-8]-LPK (2) as well as devoid of the first, second and third N-terminal a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::86da7bd9a3be3ba2dbc8b7278a61fe43
https://pubmed.ncbi.nlm.nih.gov/9437758

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Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability

Autor: D L, Greene, V S, Hau, T J, Abbruscato, H, Bartosz, A, Misicka, A W, Lipkowski, S, Hom, T J, Gillespie, V J, Hruby, T P, Davis

Publikováno v: The Journal of pharmacology and experimental therapeutics. 277(3)

To improve the blood-brain barrier penetration of the delta-opioid receptor peptides [D-Pen2, D-Pen5]enkephalin (DPDPE) and [D-Pen2, L-Cys5]enkephalin (DPLCE), various prodrug forms were synthesized to increase lipophilicity and drug delivery to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc1a2842dfab76de71857cb389be6976
https://pubmed.ncbi.nlm.nih.gov/8667199

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Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs

Autor: S J, Weber, T J, Abbruscato, E A, Brownson, A W, Lipkowski, R, Polt, A, Misicka, R C, Haaseth, H, Bartosz, V J, Hruby, T P, Davis

Publikováno v: The Journal of pharmacology and experimental therapeutics. 266(3)

Confluent monolayers of primary and continuous passaged cultures of bovine brain microvessel endothelial cells (BMEC) have been suggested to model the blood-brain barrier (BBB). Increased lipophilicity has been previously suggested to increase BBB pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01169563b09c0ae3ab3018f5b73dfceb
https://pubmed.ncbi.nlm.nih.gov/8371162

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