Výsledky vyhledávání - "H, Bénédetti"

The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes

Autor: Wissem Deraredj Nadim, Séverine Morisset-Lopez, Catherine Grillon, Shalina Hassanaly, Claudine Kieda, H. Bénédetti

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2021, 534, pp.758-764. ⟨10.1016/j.bbrc.2020.11.003⟩
Biochemical and Biophysical Research Communications, 2021, 534, pp.758-764. ⟨10.1016/j.bbrc.2020.11.003⟩

International audience; The melanocortin 1 receptor (MC1R) is a G-protein coupled receptor (GPCR) which plays a major role in controlling melanogenesis. A large body of evidence indicates that GPCRs are part of large protein complexes that are critic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043e524aa8a5768b55e882e8dbadb673
https://hal.archives-ouvertes.fr/hal-03007433

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Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein

Autor: F. Godin, M. Doudeau, H. Bénédetti, Béatrice Vallée

Publikováno v: Journal of visualized experiments : JoVE
Journal of visualized experiments : JoVE, JoVE, 2019, pp.e59820. ⟨10.3791/59820⟩
Journal of visualized experiments : JoVE, JoVE, 2019, ⟨10.3791/59820⟩
Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩

Extensive whole genome sequencing has identified many Open Reading Frames (ORFs) providing many potential proteins. These proteins may have important roles for the cell and may unravel new cellular processes. Among proteins, kinases are major actors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271b5a37e84df99e9a458d2aba2ae76b
https://hal.archives-ouvertes.fr/hal-02282630/document

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LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b

Autor: David Gosset, Patrick Vourc'h, H. Bénédetti, Hélène Cuberos, Christian R. Andres, M. Doudeau, Béatrice Vallée, F. Godin

Publikováno v: The Biochemical journal. 475(23)

LIMK1 and LIMK2 (LIMKs, LIM kinases) are kinases that play a crucial role in cytoskeleton dynamics by independently regulating both actin filament and microtubule remodeling. LIMK1 and, more recently, LIMK2 have been shown to be involved in cancer de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05af57157866ce49c21d6c4fae542911
https://pubmed.ncbi.nlm.nih.gov/30373762

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Targeting thecis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling

Autor: E. Kellenberger, Jacques Pantel, J Ferent, I Hénaoui, Séverine Morisset-Lopez, F Godin, E. Traiffort, L. Cobret, M.-L. de Tauzia, H. Bénédetti, Didier Rognan

Publikováno v: British Journal of Pharmacology. 172:841-856

Background and Purpose The transmembrane protein LINGO-1 is a negative regulator in the nervous system mainly affecting axonal regeneration, neuronal survival, oligodendrocyte differentiation and myelination. However, the molecular mechanisms regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a31b5808a0363fa19d221e7d6ea647c4
https://doi.org/10.1111/bph.12945

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Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity

Autor: Wissem Deraredj Nadim, Paweł Zajdel, Séverine Chaumont-Dubel, L. Cobret, Séverine Morisset-Lopez, Fahima Madouri, Marie-Ludivine de Tauzia, H. Bénédetti, Philippe Marin

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (43), pp.12310-12315. ⟨10.1073/pnas.1600914113⟩

International audience; Active G protein-coupled receptor (GPCR) conformations not only are promoted by agonists but also occur in their absence, leading to constitutive activity. Association of GPCRs with intracellular protein partners might be one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1ae9f912a823b1429e51f2dc63ba87
https://pubmed.ncbi.nlm.nih.gov/27791021

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