Zobrazeno 1 - 10
of 1 365
pro vyhledávání: '"H, Appel"'
Autor:
Yijian Meng, Ming Lai Chan, Rasmus B. Nielsen, Martin H. Appel, Zhe Liu, Ying Wang, Nikolai Bart, Andreas D. Wieck, Arne Ludwig, Leonardo Midolo, Alexey Tiranov, Anders S. Sørensen, Peter Lodahl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Deterministic photon sources allow long-term advancements in quantum optics. A single quantum emitter embedded in a photonic resonator or waveguide may be triggered to emit one photon at a time into a desired optical mode. By coherently cont
Externí odkaz:
https://doaj.org/article/355acca573f64019a2011d5ac2e67f64
Autor:
Steven Perrin, Shafeeq Ladha, Nicholas Maragakis, Michael H Rivner, Jonathan Katz, Angela Genge, Nicholas Olney, Dale Lange, Daragh Heitzman, Cynthia Bodkin, Omar Jawdat, Namita A Goyal, Jeffrey D Bornstein, Carmen Mak, Stanley H Appel, Sabrina Paganoni
Publikováno v:
PLoS Medicine, Vol 21, Iss 10, p e1004469 (2024)
BackgroundThe interaction of CD40L and its receptor CD40 on activated T cells and B cells respectively control pro-inflammatory activation in the pathophysiology of autoimmunity and transplant rejection. Previous studies have implicated signaling pat
Externí odkaz:
https://doaj.org/article/bfaf649e6f014ac693adbf9dd52386e8
Autor:
Jason R. Thonhoff, David R. Beers, Weihua Zhao, Alireza Faridar, Aaron Thome, Shixiang Wen, Aijun Zhang, Jinghong Wang, Stanley H. Appel
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
ObjectiveTo determine whether a combination therapy with abatacept (CTLA4-Ig) and interleukin-2 (IL-2) is safe and suppresses markers of oxidative stress, inflammation, and degeneration in ALS.MethodsIn this open-label study, four participants with A
Externí odkaz:
https://doaj.org/article/23b3a503a45b412f8431ba1083024eb8
Autor:
Alireza Faridar, Abdulmunaim M. Eid, Aaron D. Thome, Weihua Zhao, David R. Beers, Maria B. Pascual, Mohammad O. Nakawah, Gustavo C. Roman, Charles S. Davis, Michael Grundman, Joseph C. Masdeu, Stanley H. Appel
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-4 (2023)
Trial registration ClinicalTrials.gov Identifier: NCT05821153, Registered April 20 2023, Retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT05821153
Externí odkaz:
https://doaj.org/article/e8a0ebe6290e4359b7e72393eaf523ef
Autor:
Alireza Faridar, Matthew Vasquez, Aaron D. Thome, Zheng Yin, Hui Xuan, Jing Hong Wang, Shixiang Wen, Xuping Li, Jason R. Thonhoff, Weihua Zhao, Hong Zhao, David R. Beers, Stephen T. C. Wong, Joseph C. Masdeu, Stanley H. Appel
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Background Regulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation and modulating adaptive immune reactions. We previously documented that Treg immunomodulatory mechanisms are comp
Externí odkaz:
https://doaj.org/article/52b183fb078941b9b217ebdf26d36db7
Autor:
Xinghan Guo, Alexander M. Stramma, Zixi Li, William G. Roth, Benchen Huang, Yu Jin, Ryan A. Parker, Jesús Arjona Martínez, Noah Shofer, Cathryn P. Michaels, Carola P. Purser, Martin H. Appel, Evgeny M. Alexeev, Tianle Liu, Andrea C. Ferrari, David D. Awschalom, Nazar Delegan, Benjamin Pingault, Giulia Galli, F. Joseph Heremans, Mete Atatüre, Alexander A. High
Publikováno v:
Physical Review X, Vol 13, Iss 4, p 041037 (2023)
Robust spin-photon interfaces in solids are essential components in quantum networking and sensing technologies. Ideally, these interfaces combine a long-lived spin memory, coherent optical transitions, fast and high-fidelity spin manipulation, and s
Externí odkaz:
https://doaj.org/article/db6a40bae215418fb1b24a8503d36340
Autor:
Aaron D. Thome, Farah Atassi, Jinghong Wang, Alireza Faridar, Weihua Zhao, Jason R. Thonhoff, David R. Beers, Eugene C. Lai, Stanley H. Appel
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Inflammation is a pathological hallmark of Parkinson’s disease (PD). Chronic pro-inflammatory responses contribute to the loss of neurons in the neurodegenerative process. The present study was undertaken to define the peripheral innate an
Externí odkaz:
https://doaj.org/article/31fbf101a5d54be486190d6c220e76d4
Autor:
Aaron D. Thome, Jason R. Thonhoff, Weihua Zhao, Alireza Faridar, Jinghong Wang, David R. Beers, Stanley H. Appel
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Extracellular vehicles (EVs) are efficient biomarkers of disease and participate in disease pathogenesis; however, their use as clinical therapies to modify disease outcomes remains to be determined. Cell-based immune therapies, including regulatory
Externí odkaz:
https://doaj.org/article/d4950a1a2da241859872c70b9fd4dbf0
Autor:
David R. Beers, Weihua Zhao, Jason R. Thonhoff, Alireza Faridar, Aaron D. Thome, Shixiang Wen, Jinghong Wang, Stanley H. Appel
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 12, Iss , Pp 100209- (2021)
Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem pro-inflammatory neuromuscular disorder. Activation of programmed cell death-1 (PD-1), and its ligands, programmed cell death-ligand 1 and 2 (PD-L1/L2), leads to immune suppression.
Externí odkaz:
https://doaj.org/article/02c2c05243564fc2af7fc3db2353d077
Publikováno v:
Biology Open, Vol 9, Iss 10 (2020)
The Rab11 apical recycling endosome pathway is a well-established regulator of polarity and lumen formation; however, Rab11-vesicular trafficking also directs a diverse array of other cellular processes, raising the question of how Rab11 vesicles ach
Externí odkaz:
https://doaj.org/article/cfd20f31f65d4b8a8cb6bff97118cd53