Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Gyutae Lim"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13337 (2023)
Protein model refinement a the crucial step in improving the quality of a predicted protein model. This study presents an NMR refinement protocol called TrioSA (torsion-angle and implicit-solvation-optimized simulated annealing) that improves the acc
Externí odkaz:
https://doaj.org/article/e62bfcba34c84997a96fa8c60b4520bf
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Drug repositioning research using transcriptome data has recently attracted attention. In this study, we attempted to identify new target proteins of the urotensin-II receptor antagonist, KR-37524 (4-(3-bromo-4-(piperidin-4-yloxy)benzyl)-N-(
Externí odkaz:
https://doaj.org/article/5e79377f13c34e84b8825e436aafd9b7
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1671 (2022)
The Forkhead box protein M1 (FoxM1) is an appealing target for anti-cancer therapeutics as this cell proliferation-associated transcription factor is overexpressed in most human cancers. FoxM1 is involved in tumor invasion, angiogenesis, and metastas
Externí odkaz:
https://doaj.org/article/f491864bd386415e8725e730aca774b9
Autor:
Gyutae Lim, Ka Young You, Jeong Hyun Lee, Moon Kook Jeon, Byung Ho Lee, Jae Yong Ryu, Kwang-Seok Oh
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3807 (2022)
Melanin-concentrating hormone receptor 1 (MCHR1) has been a target for appetite suppressants, which are helpful in treating obesity. However, it is challenging to develop an MCHR1 antagonist because its binding site is similar to that of the human Et
Externí odkaz:
https://doaj.org/article/ce33a5ce83ab47d79846373680d6c6af
Autor:
Jiyeun Yi, Jinhyuk Lee, Bong Hyun Sung, Du-Kyeong Kang, GyuTae Lim, Jung-Hoon Bae, Seung-Goo Lee, Sun Chang Kim, Jung-Hoon Sohn
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract Methanol dehydrogenase (MDH), an NAD+-dependent oxidoreductase, reversibly converts formaldehyde to methanol. This activity is a key step for both toxic formaldehyde elimination and methanol production in bacterial methylotrophy. We mutated
Externí odkaz:
https://doaj.org/article/2bea7df7aed04a27bf1f7afbbc10fee8
Discovery of Natural Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches
Publikováno v:
Nutrients, Vol 13, Iss 1, p 254 (2021)
Alzheimer’s disease (AD) is a neurodegenerative disease conceptualized as a clinical-biological neurodegenerative construct where amyloid-beta pathophysiology is supposed to play a role. The loss of cognitive functions is mostly characterized by th
Externí odkaz:
https://doaj.org/article/b0dd17bbbbbb43449c0fab84ca2c4f74
Autor:
Kumju Youn, Jeong-Hyun Yoon, Nayoung Lee, Gyutae Lim, Jinhyuk Lee, Shengmin Sang, Chi-Tang Ho, Mira Jun
Publikováno v:
Nutrients, Vol 12, Iss 10, p 3026 (2020)
BACE1 is the rate-limiting enzyme involved in the production and deposition of β-amyloid (Aβ). Since neurotoxic Aβ plays a critical role in Alzheimer’s disease (AD) pathogenesis, BACE1 has emerged as a key target for preventing AD. In the presen
Externí odkaz:
https://doaj.org/article/0500f27bbd234ae7a59a45c6c7c63f29
Autor:
Jayeong Hwang, Kumju Youn, Yeongseon Ji, Seonah Lee, Gyutae Lim, Jinhyuk Lee, Chi-Tang Ho, Sun-Hee Leem, Mira Jun
Publikováno v:
Nutrients, Vol 12, Iss 5, p 1215 (2020)
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) mediate the degradation of acetylcholine (ACh), a primary neurotransmitter in the brain. Cholinergic deficiency occurs during the progression of Alzheimer’s disease (AD), resulting in wid
Externí odkaz:
https://doaj.org/article/85e00c535482489ba6a542c9eb789b51
Publikováno v:
Nutrients, Vol 11, Iss 11, p 2694 (2019)
One of the major neurodegenerative features of Alzheimer’s disease (AD) is the presence of neurotoxic amyloid plaques composed of amyloid beta peptide (Aβ). β-Secretase (BACE1) and acetylcholinesterase (AChE), which promote Aβ fibril formation,
Externí odkaz:
https://doaj.org/article/ac0d0049ab7f482daee4c0059ed9a63e
Publikováno v:
Molecules, Vol 23, Iss 7, p 1509 (2018)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, distinctively characterized by senile plaques, neurofibrillary tangles, and synaptic loss, finally resulting in neuronal death. β-Site amyloid precursor protein (APP) cleavi
Externí odkaz:
https://doaj.org/article/0cfabcf8b8254f32af08dde9c268c601