The role of singlet oxygen and hydroxyl radical in the photobleaching of meso-substituted cationic pyridyl porphyrins in the presence of folic acid

Autor: Lusine Mkrtchyan, Torgom Seferyan, Marina Parkhats, Sergei Lepeshkevich, Boris Dzhagarov, Gagik Shmavonyan, Elena Tuchina, Valery Tuchin, Grigor Gyulkhandanyan

Publikováno v: Journal of Innovative Optical Health Sciences, Vol 17, Iss 05 (2024)

Using a photosensitizer (PS), light, and oxygen, photodynamic therapy creates cytotoxic reactive oxygen species, such as singlet oxygen (1O2), that kill cancer cells. Many cancer cell lines have up to 300 times more folic acid receptors than healthy

Externí odkaz: https://doaj.org/article/1bedc6b1211b491f8f08aa5acf52054b

Meso-substituted cationic 3- and 4-N-Pyridylporphyrins and their Zn(II) derivatives for antibacterial photodynamic therapy

Autor: Aram G. Gyulkhandanyan, Marina H. Paronyan, Anna G. Gyulkhandanyan, Karapet R. Ghazaryan, Marina V. Parkhats, Boris M. Dzhagarov, Maria V. Korchenova, Ekaterina N. Lazareva, Elena S. Tuchina, Grigor V. Gyulkhandanyan, Valery V. Tuchin

Publikováno v: Journal of Innovative Optical Health Sciences, Vol 15, Iss 1, Pp 2142007-1-2142007-16 (2022)

Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy (APDT) is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms. Among the photosensitizers (PSs), compounds based

Externí odkaz: https://doaj.org/article/e968fa0d2237418aaf0eca341b9d7e26

Analysis of protein missense alterations by combining sequence‐ and structure‐based methods

Autor: Aram Gyulkhandanyan, Alireza R. Rezaie, Lubka Roumenina, Nathalie Lagarde, Veronique Fremeaux‐Bacchi, Maria A. Miteva, Bruno O. Villoutreix

Publikováno v: Molecular Genetics & Genomic Medicine, Vol 8, Iss 4, Pp n/a-n/a (2020)

Abstract Background Different types of in silico approaches can be used to predict the phenotypic consequence of missense variants. Such algorithms are often categorized as sequence based or structure based, when they necessitate 3D structural inform

Externí odkaz: https://doaj.org/article/600b4f286a21496d8eb8dd6dc8fa9ec1

Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors

Autor: Valery Leytin PhD, Armen V. Gyulkhandanyan PhD, John Freedman MD

Publikováno v: Clinical and Applied Thrombosis/Hemostasis, Vol 25 (2019)

In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane. In this review, we pr

Externí odkaz: https://doaj.org/article/e34d439cad974b56842b0d14368f04f4

Meso-substituted cationic 3- and 4-N-Pyridylporphyrins and their Zn(II) derivatives for antibacterial photodynamic therapy

Autor: Valery V. Tuchin, Karapet R. Ghazaryan, Anna G. Gyulkhandanyan, Grigor V. Gyulkhandanyan, Marina H. Paronyan, Ekaterina N. Lazareva, Elena S. Tuchina, Maria V. Korchenova, Boris M. Dzhagarov, Marina V. Parkhats, Aram G. Gyulkhandanyan

Publikováno v: Journal of innovative optical health sciences. 2022. Vol. 15, № 1. P. 2142007-1-2142007-16
Journal of Innovative Optical Health Sciences, Vol 15, Iss 1, Pp 2142007-1-2142007-16 (2022)

Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy (APDT) is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms. Among the photosensitizers (PSs), compounds based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802c7cb4400835c9e523159e134075bc
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