Výsledky vyhledávání - "Gyula Varadi"

Akademický článek

Efficient Transdermal Delivery of Benfotiamine in an Animal Model

Autor: Gyula Varadi, Zhen Zhu, Stephen G. Carter

Publikováno v: ADMET and DMPK, Vol 2, Iss 4, Pp 272-281 (2015)

We designed a transdermal system to serve as a delivery platform for benfotiamine utilizing the attributes of passive penetration enhancing molecules to penetrate through the outer layers of skin combined with the advance of incorporating various per

Externí odkaz: https://doaj.org/article/cc9a0041d2f444d08c35a0ebcfd8a3c5

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Examining the Systemic Bioavailability of Cannabidiol and Tetrahydrocannabinol from a Novel Transdermal Delivery System in Healthy Adults: A Single-Arm, Open-Label, Exploratory Study

Autor: Gyula Varadi, Zhen Zhu, Henry D. Crowley, Marc Moulin, Rajib Dey, Erin D. Lewis, Malkanthi Evans

Publikováno v: Advances in therapy.

Transdermal cannabinoids may provide better safety and bioavailability profiles compared with other routes of administration. This single-arm, open-label study investigated a novel topical transdermal delivery system on the pharmacokinetics of cannab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c15ce540d8a64047f8fc8b9182f019
https://pubmed.ncbi.nlm.nih.gov/36308640

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The effect of cane girdling on berry skin phenolic concentration of three table grape varieties

Autor: Edit Hajdu, Szabolcs Villangó, Borbála Bálo, Gyula Varadi, Zsolt Zsófi, Gábor Zanathy, György Lukácsy

Publikováno v: Journal of Central European Agriculture, Vol 22, Iss 2, Pp 341-345 (2021)

The effect of cane girdling on grape skin phenolic composition and concentration was examined on three Hungarian table grape varieties, i.e. noir-skinned 'Esther', rose-skinned 'Lidi', and blanc-skinned 'Fanny'. Girdling was conducted at the BBCH 75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abee0c528a747eb27a7c5aeb6d2bc63
https://doi.org/10.5513/jcea01/22.2.3152

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Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials

Autor: Mohammad Hashem Hashempur, Joanne Stocks, Sita M A Bierma-Zeinstra, David A. Walsh, Weiya Zhang, Monica S M Persson, Gyula Varadi, Michael Doherty, Marienke van Middelkoop

Publikováno v: Rheumatology (Oxford, England), 59(9), 2207-2216
Rheumatology (Oxford, England)

ObjectivesTo identify predictors of the specific (difference between treatment and placebo) and overall (change from baseline in treatment arm) treatment effects of topical NSAIDs in OA.MethodsRandomized controlled trials (RCTs) of topical NSAIDs in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece9ed06f1606b578d451563dcc84638
https://pure.eur.nl/en/publications/331b4d13-0345-46fd-b456-90b4df76937a

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THU0447 THE RELATIVE EFFICACY OF TOPICAL NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND CAPSAICIN IN OSTEOARTHRITIS: MOVING FROM AVERAGE TREATMENT EFFECTS TO INDIVIDUAL TREATMENT PREFERENCES

Autor: David A. Walsh, Gwen Sascha Fernandes, Robbert van Haselen, Joanne Stocks, Aliya Sarmanova, Weiya Zhang, Monica S M Persson, Michael Doherty, Mohammad Hashem Hashempur, Gyula Varadi

Publikováno v: Poster Presentations.

Background: Pain is an important issue for people with osteoarthritis (OA). Topical non-steroidal anti-inflammatory drugs (tNSAIDs) and capsaicin are recommended treatments, but reduce OA pain by different mechanisms. Objectives: To [1] determine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30140df5867f2f20b53e14ccd0552f8b
https://doi.org/10.1136/annrheumdis-2019-eular.699

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Efficient Transdermal Delivery of Benfotiamine in an Animal Model

Autor: Stephen G. Carter, Gyula Varadi, Zhen Zhu

Publikováno v: ADMET and DMPK, Vol 2, Iss 4, Pp 272-281 (2015)
ADMET and DMPK
Volume 2
Issue 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa7908ca46e323cb8e6e3fb97697885
http://pub.iapchem.org/ojs/index.php/admet/article/view/130

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Randomized Clinical Trial Evaluating Transdermal Ibuprofen for Moderate to Severe Knee Osteoarthritis

Autor: Rolf Pokorny, Thomas Blättler, Manfred Hösle, Zhen Zhu, Diana Frey, Stephen G. Carter, Alfons Loher, Gyula Varadi

Publikováno v: Pain Physician. :E749-E762

Background: Osteoarthritis is a common condition, typically treated with orally administered analgesics and non-steroidal anti-inflammatory drugs (NSAIDs). Chronic administration of NSAIDs, serotoninnorepinephrine reuptake inhibitors (SNRIs, i.e., du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2b7ad3673287d9dc684fc9bdd68316
https://doi.org/10.36076/ppj.2013/16/e749

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Limits of the Classical Concept of Concentration

Autor: Marco Maioli, Gyula Pályi, Luciano Caglioti, Róbert Kurdi, Gyula Varadi

Publikováno v: The journal of physical chemistry. B. 120(30)

Solutions of very low concentrations cannot be treated by the usual concept of concentration. Stochastic calculations are performed for the analysis of such solutions containing one or a few molecule(s). It is concluded that these systems escape the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f595032005bb60c32835bce9bcaa79
https://pubmed.ncbi.nlm.nih.gov/27384879

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Ca2+-dependent modulation of single human cardiac L-type calcium channels by the calcineurin inhibitor cyclosporine

Autor: Robert H. G. Schwinger, Arnold Schwartz, Stefan Herzig, Jan Matthes, Renate Handrock, Andreas Jäger, Uwe Mehlhorn, Ferdi Groner, Gyula Varadi

Publikováno v: Journal of Molecular and Cellular Cardiology. 36:241-255

Objective. – Activity of single L-type calcium channels (LTCC) is enhanced in human failing myocardium (Circulation 98 (1998) 969.), most likely due to impaired dephosphorylation. Protein phosphatase 2B (calcineurin) has recently been shown to be i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7ab061bd2da2a274c53a06211e7537
https://doi.org/10.1016/j.yjmcc.2003.11.013

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Cardiac L-type Calcium Channel β-Subunits Expressed in Human Heart Have Differential Effects on Single Channel Characteristics

Autor: Roger Hullin, Arnold Schwartz, Stefan Herzig, Paul Mohacsi, Ismail F. Y. Khan, Gyula Varadi, Susanne Wirtz

Publikováno v: Journal of Biological Chemistry. 278:21623-21630

l-Type calcium channels are multiprotein complexes composed of pore-forming (CaV1.2) and modulatory auxiliary alpha2delta- and beta-subunits. We demonstrate expression of two different isoforms for the beta2-subunit (beta2a, beta2b) and the beta3-sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76327fc9c3d1546805bc5b7217b4aef
https://doi.org/10.1074/jbc.m211164200

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