Výsledky vyhledávání - "Gyula Bugovics"

Comparative pharmacology of adrenergic α2C receptors coupled to Ca2+ signaling through different Gα proteins

Autor: József Nagy, Sándor Kolok, Zsófia Bekes, Aniko Gere, Gyula Bugovics, András Boros, Zsolt Szombathelyi, Andrea Baki, Dalma Kurkó, Györgyi Ignácz-Szendrei

Publikováno v: Neurochemistry International. 55:467-475

Adrenergic alpha(1), alpha(2) and beta receptors are members of the G-protein-coupled receptor families (GPCRs) mediating physiological responses to adrenaline (epinephrine) and noradrenaline (norepinephrine). Since GPCRs are major targets for potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5483a1bf4e94001593b00e7cf4bfbf
https://doi.org/10.1016/j.neuint.2009.04.015

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Antiapoptotic effect of benzyloxycarbonyl-aspartyl-(β-tertier-butyl ester)-bromomethylketone (z-d(otbu)-bmk), an intermediate of interleukin-lβ converting enzyme inhibitors

Autor: Klára Németh, József I. Székely, Gyula Bugovics

Publikováno v: International Journal of Immunopharmacology. 19:215-225

The effect of several interleukin-1β converting enzyme (ICE) inhibitors on apoptosis was examined. The ICE inhibitors tested were peptide aldehydes such as ethyloxycarbonyl-Ala-Tyr-Val-Ala-Asp-aldehyde (Etoco-AYVAD-CHO), acetyl-Tyr-Val-Ala-Asp-aldeh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f6a1b328235b4d939a83beef0358277
https://doi.org/10.1016/s0192-0561(97)00026-x

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Effect of Interleukin-1β on Plasma ACTH, β-Endorphin, and Corticosterone Levels in Infant and Prepubertal Rats

Autor: István Barna, James I Koenig, Zsuzsanna Ács, Gyula Bugovics

Publikováno v: Pediatric Research. 37:714-719

IL-1 beta is known to enhance ACTH release from the anterior pituitary in the adult rat, mainly by simulating the hypothalamic ACTH-releasing hormone (CRH) release, but it seems to have a direct effect on the pituitary and on the adrenal hormone secr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11fe4a67140dd28bbd53015d1ae4e7a
https://doi.org/10.1203/00006450-199506000-00007

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Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15

Autor: Gyula Bugovics, Attila Horváth, Bela Kiss, Károly Fazekas, Zsolt Szombathelyi, Istvan Gyertyan, Zsolt Némethy, István Laszlovszky, Éva Ágai-Csongor, Eva Schmidt, György Domány

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 378(5)

RG-15 (trans-N-[4-[2-[4-(3-cyano-5-trifluoromethyl-phenyl)-piperazine-1-yl]-ethyl]-cyclohexyl]-3-pyridinesulfonic amide dihydrochloride) displayed subnanomolar affinity to human and rat dopamine D3 receptors (pKi 10.49 and 9.42, respectively) and nan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad763985a4b795de64ef552ab4049c2b
https://pubmed.ncbi.nlm.nih.gov/18551280

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Allosteric modulation of 5-HT3 serotonin receptors

Autor: Gábor Maksay, Gyula Bugovics, Tímea Bíró

Publikováno v: European journal of pharmacology. 514(1)

[(3)H]Granisetron binding to 5-HT(3) type serotonin receptors was examined in homogenates of rat forebrain and NG 108-15 cells. We have applied an allosteric model to 5-HT(3) receptor binding for the first time. Slope factors of displacement improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf9e44abb2f141856d09165d2e68abc
https://pubmed.ncbi.nlm.nih.gov/15878320

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