Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Gyujin Park"'
Autor:
Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Yusuke Masuo, Yuka Inaba, Takanori Tatsuno, Takanori Yamada, Kazuya Tokumura, Sayuki Iwahashi, Takashi Iezaki, Katsuyuki Kaneda, Yukio Kato, Yasuhito Ishigaki, Michihiro Mieda, Tomohiro Tanaka, Kazuma Ogawa, Hiroki Ochi, Shingo Sato, Yun-Bo Shi, Hiroshi Inoue, Hojoon Lee, Eiichi Hinoi
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Hypothalamic neurons regulate body homeostasis by sensing and integrating changes in the levels of key hormones and primary nutrients (amino acids, glucose, and lipids). However, the molecular mechanisms that enable hypothalamic neurons to detect pri
Externí odkaz:
https://doaj.org/article/69274c6ccd734fd68d05813f708b0c90
Autor:
Manami Hiraiwa, Kazuya Fukasawa, Takashi Iezaki, Hemragul Sabit, Tetsuhiro Horie, Kazuya Tokumura, Sayuki Iwahashi, Misato Murata, Masaki Kobayashi, Akane Suzuki, Gyujin Park, Katsuyuki Kaneda, Tomoki Todo, Atsushi Hirao, Mitsutoshi Nakada, Eiichi Hinoi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Hiraiwa et al. show that phosphorylation of SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) at Thr249 mediates ubiquitylation and degradation of the TGF-β receptor TGBR1 leading to loss of glioblastoma stem cell tumorigenic capacity. Their data
Externí odkaz:
https://doaj.org/article/947620c5dbce49479302679a911d0d45
Autor:
Shinsuke Ochiai, Kazuya Tokumura, Gyujin Park, Kakeru Ozaki, Tetsuhiro Horie, Takanori Yamada, Sayuki Iwahashi, Kaname Ohta, Hiroki Fusawa, Yasuka Okayama, Katsuyuki Kaneda, Takashi Iezaki, Eiichi Hinoi
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 1-5 (2021)
Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailt
Externí odkaz:
https://doaj.org/article/8bb19e32b3b8492a93d071b9d27caabe
Autor:
Takashi Iezaki, Tetsuhiro Horie, Kazuya Fukasawa, Makoto Kitabatake, Yuka Nakamura, Gyujin Park, Yuki Onishi, Kakeru Ozaki, Takashi Kanayama, Manami Hiraiwa, Yuka Kitaguchi, Katsuyuki Kaneda, Takayuki Manabe, Yasuhito Ishigaki, Mutsuhito Ohno, Eiichi Hinoi
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 228-241 (2018)
Summary: The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs
Externí odkaz:
https://doaj.org/article/a74140fb7e634b20b5faa27345d65c2c
Autor:
Manami Hiraiwa, Kakeru Ozaki, Takanori Yamada, Takashi Iezaki, Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Hikari Kamada, Kazuya Tokumura, Mei Motono, Katsuyuki Kaneda, Eiichi Hinoi
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The mechanistic/mammalian target of rapamycin (mTOR) is widely implicated in the pathogenesis of various diseases, including cancer, obesity, and cardiovascular disease. Bone homeostasis is maintained by the actions of bone-resorbing osteoclasts and
Externí odkaz:
https://doaj.org/article/77d5728b82864ecfb103a2d6f83a5a78
Autor:
Gyujin Park, Changhee Lee
Publikováno v:
Applied Sciences, Vol 9, Iss 15, p 3100 (2019)
A numerical study is conducted on the thermal performance of a large-area hot plate specifically designed as a heating and cooling tool for thermal nanoimprint lithography processes. The hot plate has the dimensions 240 mm × 240 mm × 20 mm, in whic
Externí odkaz:
https://doaj.org/article/3395e32966ae4911821f46b543df26b6
Autor:
Sayuki Iwahashi, Jiajun Lyu, Kazuya Tokumura, Ryoma Osumi, Manami Hiraiwa, Takuya Kubo, Tetsuhiro Horie, Satoru Demura, Noriaki Kawakami, Taku Saito, Gyujin Park, Kazuya Fukasawa, Takashi Iezaki, Akane Suzuki, Akane Tomizawa, Hiroki Ochi, Hironori Hojo, Shinsuke Ohba, Eiichi Hinoi
Publikováno v:
Journal of Cellular Physiology. 237:4292-4302
Scoliosis, usually diagnosed in childhood and early adolescence, is an abnormal lateral curvature of the spine. L-type amino acid transporter 1 (LAT1), encoded by solute carrier transporter 7a5 (Slc7a5), plays a crucial role in amino acid sensing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2cda1add0dc93d47f653c22f0a29cc
https://doi.org/10.1002/jcp.30883
https://doi.org/10.1002/jcp.30883
Autor:
Sayuki Iwahashi, Jiajun Lyu, Kazuya Tokumura, Ryoma Osumi, Manami Hiraiwa, Takuya Kubo, Tetsuhiro Horie, Satoru Demura, Noriaki Kawakami, Taku Saito, Gyujin Park, Kazuya Fukasawa, Takashi Iezaki, Akane Suzuki, Akane Tomizawa, Hiroki Ochi, Hironori Hojo, Shinsuke Ohba, Eiichi Hinoi
Publikováno v:
Journal of Cellular Physiology. 237
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f8c6c6fbc05f05e2a09a99082eb05a
https://doi.org/10.1002/jcp.30926
https://doi.org/10.1002/jcp.30926
Autor:
Kazuya Tokumura, Ryuichi Terada, Gyujin Park, Eiichi Hinoi, Hiroaki Shirahase, Takashi Iezaki, Richard W. Wong, Tomoki Todo, Manami Hiraiwa, Atsushi Hirao, Tatsuya Kitao, Masaharu Hazawa, Katsuyuki Kaneda, Tetsuhiro Horie, Shinsuke Ochiai, Yasuka Okayama, Sayuki Iwahashi, Takuya Kadota, Kazuya Fukasawa, Takanori Yamada, Megumi Yamamoto, Yuka Kitaguchi
Publikováno v:
Oncogene. 40:2803-2815
Glioblastoma (GBM) is the most malignant form of glioma. Glioma stem cells (GSCs) contribute to the initiation, progression, and recurrence of GBM as a result of their self-renewal potential and tumorigenicity. Cyclin-dependent kinase 8 (CDK8) belong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9059b0eaacdd605b11905b0dbc527195
https://doi.org/10.1038/s41388-021-01745-1
https://doi.org/10.1038/s41388-021-01745-1
Autor:
Kazuya Tokumura, Eiichi Hinoi, Katsuyuki Kaneda, Sayuki Iwahashi, Kaname Ohta, Tetsuhiro Horie, Takashi Iezaki, Gyujin Park, Shinsuke Ochiai, Hiroki Fusawa, Yasuka Okayama, Kakeru Ozaki, Takanori Yamada
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 1-5 (2021)
Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8b3a61f05bb5662ca2889448198cc3
https://doi.org/10.1016/j.jphs.2020.09.007
https://doi.org/10.1016/j.jphs.2020.09.007