Zobrazeno 1 - 10 of 89 pro vyhledávání: '"Gyudong, Kim"'
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Akademický článek
A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis
Autor: Yanran Bi, Ruiling Zheng, Jiahao Hu, Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin
Publikováno v: Genes and Diseases, Vol 11, Iss 1, Pp 479-494 (2024)
Glioblastoma (GBM) is a malignant brain tumor that grows quickly, spreads widely, and is resistant to treatment. Fibroblast growth factor receptor (FGFR)1 is a receptor tyrosine kinase that regulates cellular processes, including proliferation, survi
Externí odkaz: https://doaj.org/article/e1c66d690f71456aac0e238237e5caf8
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4
Akademický článek
Novel innovative computer-based test (Inno-CBT) item types for national licensing examinations for health care professionals
Autor: Kwang-Hoon Chun, Hye Kyung Jin, Jeong-Hyun Yoon, Myeong Gyu Kim, Kyung Hee Choi, Eunyoung Kim, Hyunah Kim, Jin-Ki Kim, Gyudong Kim, Kyungim Kim, Ju-Yeun Lee, Eun Kyoung Chung, Young Sook Lee, Sandy Jeong Rhie
Publikováno v: BMC Medical Education, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background An effective test mechanism to evaluate clinical knowledge and skills of the entry-level healthcare professionals is important for providing clinical competency and improving patient care. This study aimed to develop novel, innova
Externí odkaz: https://doaj.org/article/fdde6a36700243938ad4309bc99b7d60
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6
Synthesis of Enantiomerically Pure Pyrimidine Ribonucleosides Locked in the South Conformation
Autor: Young Eum Hyun, Dnyandev B. Jarhad, Minjae Kim, Ayeon Yang, Gyudong Kim, Hong-Rae Kim, Lak Shin Jeong
Publikováno v: Organic Letters. 24:9281-9284
The conformation of the central five-membered ring of a nucleoside plays an important role in enzyme recognition. Bicyclo[3.1.0]hexane, also known as the methanocarba (MC), serves as a template that can mimic the locked forms of the two distinctive c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2761d05a17ebf554f03853969b12ff8d
https://doi.org/10.1021/acs.orglett.2c03853
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7
Structural basis for activation of fungal sterol receptor Upc2 and azole resistance
Autor: Lingchen Tan, Lin Chen, Huiseon Yang, Binghui Jin, Gyudong Kim, Young Jun Im
Publikováno v: Nature Chemical Biology. 18:1253-1262
Fungal transcription factor Upc2 senses ergosterol levels and regulates sterol biosynthesis and uptake. Constitutive activation of Upc2 causes azole resistance in Candida species. We determined the structure of ergosterol-bound Upc2, revealing the li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105413fb5aa2ffad66cf5aa75e279a18
https://doi.org/10.1038/s41589-022-01117-0
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8
Design, Synthesis, and Biological Activity of l-1'-Homologated Adenosine Derivatives
Autor: Mai Nguyen, Seungchan An, Yen Nguyen, Young Eum Hyun, Hongseok Choi, Linh Pham, Jung-Ae Kim, Minsoo Noh, Gyudong Kim, Lak Shin Jeong
Publikováno v: ACS medicinal chemistry letters. 13(7)
On the basis of the previously reported polypharmacological profile of truncated d-1'-homologated adenosine derivatives [J. Med. Chem.2020, 63, 16012], the l-nucleoside analogues were synthesized using computer-aided design and evaluated for biologic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8ea384761a97a07bf1daa2e054d8a7
https://pubmed.ncbi.nlm.nih.gov/35859875
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