Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations.

Autor: Höglander EK; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway.; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway., Nord S; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway.; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway., Wedge DC; Big Data Institute, University of Oxford, Oxford, UK., Lingjærde OC; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.; Biomedical Informatics, Department of Informatics and Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway., Silwal-Pandit L; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway.; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway., Gythfeldt HV; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway.; Department of Oncology, Oslo University Hospital, 0407, Oslo, Norway., Vollan HKM; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway.; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Oncology, Oslo University Hospital, 0407, Oslo, Norway., Fleischer T; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway.; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway., Krohn M; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway.; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway., Schlitchting E; Section for Breast and Endocrine Surgery, Oslo University Hospital, Oslo, Norway., Borgen E; Department of Pathology, Oslo University Hospital, Oslo, Norway., Garred Ø; Department of Pathology, Oslo University Hospital, Oslo, Norway., Holmen MM; Department of Radiology, Oslo University Hospital, Oslo, Norway., Wist E; Department of Oncology, Oslo University Hospital, 0407, Oslo, Norway., Naume B; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Oncology, Oslo University Hospital, 0407, Oslo, Norway., Van Loo P; Cancer Research UK London Research Institute, London, UK., Børresen-Dale AL; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway.; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway., Engebraaten O; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway. olav.engebraten@medisin.uio.no.; Department of Oncology, Oslo University Hospital, 0407, Oslo, Norway. olav.engebraten@medisin.uio.no., Kristensen V; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway. v.n.kristensen@medisin.uio.no.; KG Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway. v.n.kristensen@medisin.uio.no.; Department of Clinical Molecular Biology (EpiGen), Divison of Medicine, Akershus University Hospital, Lørenskog, Norway. v.n.kristensen@medisin.uio.no.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. v.n.kristensen@medisin.uio.no.

Publikováno v: Genome medicine [Genome Med] 2018 Nov 29; Vol. 10 (1), pp. 92. Date of Electronic Publication: 2018 Nov 29.