Genetically programmed differences in epidermal host defense between psoriasis and atopic dermatitis patients.

Autor: Patrick L J M Zeeuwen, Gys J de Jongh, Diana Rodijk-Olthuis, Marijke Kamsteeg, Renate M Verhoosel, Michelle M van Rossum, Pieter S Hiemstra, Joost Schalkwijk

Publikováno v: PLoS ONE, Vol 3, Iss 6, p e2301 (2008)

In the past decades, chronic inflammatory diseases such as psoriasis, atopic dermatitis, asthma, Crohn's disease and celiac disease were generally regarded as immune-mediated conditions involving activated T-cells and proinflammatory cytokines produc

Externí odkaz: https://doaj.org/article/3a890d0f22654e63b80a26295f97a3b9

A partial transcriptome of human epidermis

Autor: Patrick L.J.M. Zeeuwen, Joost Schalkwijk, Gys J. de Jongh, Fred van Ruissen, Bastiaan J.H. Jansen

Publikováno v: Genomics, 79(5), 671-678. Academic Press Inc.
Genomics : International Journal of Gene Mapping and Nucleotide Sequencing Emphasizing Analyses of the Human and Other Complex Genomes, 79, 5, pp. 671-8
Genomics : International Journal of Gene Mapping and Nucleotide Sequencing Emphasizing Analyses of the Human and Other Complex Genomes, 79, 671-8

Item does not contain fulltext Serial analysis of gene expression (SAGE) is a powerful technique for global expression profiling without prior knowledge of the genes of interest. We carried out SAGE analysis of purified keratinocytes derived from hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a423fba932f6e21fa467ce44a4e6f121
https://hdl.handle.net/2066/217679

Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin

Autor: Patrick A. M. Jansen, Patrick L.J.M. Zeeuwen, Elke M. G. J. de Jong, Judith G.M. Bergboer, Michelle M. van Rossum, Andrea W M Evers, Mieke Bergers, Gys J. de Jongh, Geuranne S. Tjabringa, Diana Rodijk-Olthuis, Edward J. Hollox, Marijke Kamsteeg, Ivonne M.J.J. van Vlijmen-Willems, John A.L. Armour, Joost Schalkwijk, Martin den Heijer

Publikováno v: PLoS ONE
PLoS One, 4, 3
PLoS ONE 4 (2009) 3
PLoS ONE, Vol 4, Iss 3, p e4725 (2009)
PLoS One, 4
PLoS ONE, 4(3)

Contains fulltext : 80466.pdf (Publisher’s version ) (Open Access) BACKGROUND: Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8abfd8f28cb866e51f3748cdf47b94b
https://pubmed.ncbi.nlm.nih.gov/19266104

Psoriasis is associated with increased beta-defensin genomic copy number

Autor: John A.L. Armour, Gys J. de Jongh, Jesús Lascorz, Diana Rodijk-Olthuis, Heiko Traupe, André Reis, Peter C.M. van de Kerkhof, Ulrike Hüffmeier, Joost Schalkwijk, Edward J. Hollox, Martin den Heijer, Patrick L.J.M. Zeeuwen, Raquel Palla

Publikováno v: Nature Genetics, 40, 23-5
Nature Genetics, 40, 1, pp. 23-5

Contains fulltext : 71309.pdf (Publisher’s version ) (Closed access) Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c91f4d89dc65aa19a523cd9aab66f2c
https://doi.org/10.1038/ng.2007.48

High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis

Autor: M. Kucharekova, Pieter S. Hiemstra, Rolph Pfundt, Joost Schalkwijk, Peter C.M. van de Kerkhof, Aynur Dogan, Willeke A. M. Blokx, Patrick L.J.M. Zeeuwen, Gys J. de Jongh, Pieter G. M. Van Der Valk

Publikováno v: Journal of Investigative Dermatology, 125, 6, pp. 1163-73
Journal of Investigative Dermatology, 125, 1163-73

Contains fulltext : 47772.pdf (Publisher’s version ) (Closed access) Recently, it was shown that lesional skin of atopic dermatitis patients expresses low levels of some antimicrobial peptides, compared with psoriasis patients. Here we performed mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e340cb2ae54d7f5e600ac92807c8f5dd
https://hdl.handle.net/2066/47772