Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Gyorgy, Panyi"'
Autor:
Bence Cs. Szabo, Mate Szabo, Peter Nagy, Zoltan Varga, Gyorgy Panyi, Tamas Kovacs, Florina Zakany
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 8, Pp 100596- (2024)
Membrane lipids extensively modulate the activation gating of voltage-gated potassium channels (KV), however, much less is known about the mechanisms of ceramide and glucosylceramide actions including which structural element is the main intramolecul
Externí odkaz:
https://doaj.org/article/205b9353af6042a9b865a9ca3229b15f
Autor:
Marco Cozzolino, Gyorgy Panyi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background:The unique microenvironment in tumors inhibits the normal functioning of tumor-infiltrating lymphocytes, leading to immune evasion and cancer progression. Over-activation of KCa3.1 using positive modulators has been proposed to rescue the
Externí odkaz:
https://doaj.org/article/9efa757e6e034ca88d9dfd3d04448d90
Autor:
Lauren M. Ashwood, Khaled A. Elnahriry, Zachary K. Stewart, Thomas Shafee, Muhammad Umair Naseem, Tibor G. Szanto, Chloé A. van der Burg, Hayden L. Smith, Joachim M. Surm, Eivind A. B. Undheim, Bruno Madio, Brett R. Hamilton, Shaodong Guo, Dorothy C. C. Wai, Victoria L. Coyne, Matthew J. Phillips, Kevin J. Dudley, David A. Hurwood, Gyorgy Panyi, Glenn F. King, Ana Pavasovic, Raymond S. Norton, Peter J. Prentis
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-25 (2023)
Abstract Background The ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families in Actiniarians remain uncharacterised. One such peptide family, sea ane
Externí odkaz:
https://doaj.org/article/21a4debffec04564ae9a29b4a8776746
Autor:
Adam Feher, Zoltán Pethő, Tibor G. Szanto, Álmos Klekner, Gabor Tajti, Gyula Batta, Tibor Hortobágyi, Zoltan Varga, Albrecht Schwab, Gyorgy Panyi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Glioblastoma (GBM) is the most aggressive glial tumor, where ion channels, including KCa1.1, are candidates for new therapeutic options. Since the auxiliary subunits linked to KCa1.1 in GBM are largely unknown we used electrophysiology combi
Externí odkaz:
https://doaj.org/article/cf1b43ce89b54546b3b0602f8f0ca7fc
Autor:
Ferenc Papp, Gilman E. S. Toombes, Zoltán Pethő, Adrienn Bagosi, Adam Feher, János Almássy, Jesús Borrego, Ákos Kuki, Sándor Kéki, Gyorgy Panyi, Zoltan Varga
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Fluorometry signals indicating conformational change in an ion channel are generated by quenching amino acids and lipid effects during movement of the dye relative to the plane of the membrane.
Externí odkaz:
https://doaj.org/article/7f7b2f17186c408295029866185e676f
Autor:
Kashmala Shakeel, Timoteo Olamendi-Portugal, Muhammad Umair Naseem, Baltazar Becerril, Fernando Z. Zamudio, Gustavo Delgado-Prudencio, Lourival Domingos Possani, Gyorgy Panyi
Publikováno v:
Toxins, Vol 15, Iss 8, p 506 (2023)
Seven new peptides denominated CboK1 to CboK7 were isolated from the venom of the Mexican scorpion Centruroides bonito and their primary structures were determined. The molecular weights ranged between 3760.4 Da and 4357.9 Da, containing 32 to 39 ami
Externí odkaz:
https://doaj.org/article/0af01c9f57f1419fadadf2a3bd4fdaed
Publikováno v:
Cells, Vol 12, Iss 13, p 1700 (2023)
Every cell biological textbook teaches us that the main role of the plasma membrane is to separate cells from their neighborhood to allow for a controlled composition of the intracellular space. The mostly hydrophobic nature of the cell membrane pres
Externí odkaz:
https://doaj.org/article/4405036601e04ffd91fea8a87356a699
Autor:
Albert Vallejo-Gracia, Daniel Sastre, Magalí Colomer-Molera, Laura Solé, María Navarro-Pérez, Jesusa Capera, Sara R. Roig, Oriol Pedrós-Gámez, Irene Estadella, Orsolya Szilágyi, Gyorgy Panyi, Péter Hajdú, Antonio Felipe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating in leukocyte activation, proliferation and apoptosis. The regulatory subunit KCNE4 acts as an ancillary peptide of Kv1.3, modulates K+ cu
Externí odkaz:
https://doaj.org/article/e253620662d849e695553c79f61cab76
Autor:
Tibor G. Szanto, Adam Feher, Eva Korpos, Adrienn Gyöngyösi, Judit Kállai, Beáta Mészáros, Krisztian Ovari, Árpád Lányi, Gyorgy Panyi, Zoltan Varga
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 656 (2023)
5-chloro-2-guanidinobenzimidazole (ClGBI), a small-molecule guanidine derivative, is a known effective inhibitor of the voltage-gated proton (H+) channel (HV1, Kd ≈ 26 μM) and is widely used both in ion channel research and functional biological a
Externí odkaz:
https://doaj.org/article/e7f674d9917e473ca32a50d14f6f19ab
Autor:
Muhammad Umair Naseem, Georgina Gurrola-Briones, Margarita R. Romero-Imbachi, Jesus Borrego, Edson Carcamo-Noriega, José Beltrán-Vidal, Fernando Z. Zamudio, Kashmala Shakeel, Lourival Domingos Possani, Gyorgy Panyi
Publikováno v:
Toxins, Vol 15, Iss 1, p 41 (2023)
A novel peptide, Cm39, was identified in the venom of the scorpion Centruroides margaritatus. Its primary structure was determined. It consists of 37 amino acid residues with a MW of 3980.2 Da. The full chemical synthesis and proper folding of Cm39 w
Externí odkaz:
https://doaj.org/article/67ed73345b9a4bbebdcd2538b18b25d0