Photochemical Fingerprinting Is a Sensitive Probe for the Detection of Synthetic Cannabinoid Receptor Agonists; toward Robust Point-of-Care Detection

Autor: Rachael C. Andrews, Benedict May, Federico J. Hernández, Gyles E. Cozier, Piers A. Townsend, Oliver B. Sutcliffe, Tom S. F. Haines, Tom P. Freeman, Jennifer Scott, Stephen M. Husbands, Ian S. Blagbrough, Richard W. Bowman, Simon E. Lewis, Matthew N. Grayson, Rachel Crespo-Otero, David R. Carbery, Christopher R. Pudney

Publikováno v: Andrews, R, May, B, Hernández, F J, Townsend, P, Cozier, G, Sutcliffe, O B, Haines, T S F, Freeman, T, Scott, J, Husbands, S, Blagbrough, I, Bowman, R, Lewis, S, Grayson, M, Crespo-Otero, R, Carbery, D & Pudney, C 2023, ' Photochemical Fingerprinting Is a Sensitive Probe for the Detection of Synthetic Cannabinoid Receptor Agonists; Toward Robust Point-of-Care Detection ', Analytical Chemistry, vol. 95, no. 2, pp. 703-713 . https://doi.org/10.1021/acs.analchem.2c02529

With synthetic cannabinoid receptor agonist (SCRA) use still prevalent across Europe and structurally advanced generations emerging, it is imperative that drug detection methods advance in parallel. SCRAs are a chemically diverse and evolving group,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb29a0a735fdb72df53a08ddda7c2b1
https://pubmed.ncbi.nlm.nih.gov/36599091

Structural basis for the inhibition of human angiotensin-1 converting enzyme by fosinoprilat

Autor: Gyles E. Cozier, Emma C. Newby, Sylva L. U. Schwager, R. Elwyn Isaac, Edward D. Sturrock, K. Ravi Acharya

Publikováno v: The FEBS journalReferences. 289(21)

Human angiotensin I-converting enzyme (ACE) has two isoforms, somatic ACE (sACE) and testis ACE (tACE). The functions of sACE are widespread, with its involvement in blood pressure regulation most extensively studied. sACE is composed of an N-domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5298e711158677fe3cb44701c28de217
https://pubmed.ncbi.nlm.nih.gov/35653492

ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

Autor: K. Ravi Acharya, Lizelle Lubbe, Delia Oosthuizen, Gyles E. Cozier, Edward D. Sturrock

Publikováno v: Clinical Science
Clinical Science (London, England : 1979)

Angiotensin converting enzyme (ACE) is well-known for its role in blood pressure regulation via the renin–angiotensin aldosterone system (RAAS) but also functions in fertility, immunity, haematopoiesis and diseases such as obesity, fibrosis and Alz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f1d6d8ee7386e984aefeff3c956cb3
https://doi.org/10.1042/cs20200899

ACE-domain selectivity extends beyond direct interacting residues at the active site

Autor: Gyles E. Cozier, Lizelle Lubbe, Edward D. Sturrock, K.R. Acharya

Publikováno v: Cozier, G, Lubbe, L, Sturrock, E & Acharya, R 2020, ' ACE-domain selectivity extends beyond direct interacting residues at the active site ', Biochemical Journal, vol. 477, no. 7, pp. 1241-1259 . https://doi.org/10.1042/BCJ20200060
Biochemical Journal

Angiotensin-converting enzyme (ACE) is best known for its formation of the vasopressor angiotensin II that controls blood pressure but is also involved in other physiological functions through the hydrolysis of a variety of peptide substrates. The en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9c544569721bb601420dc617dfb8f9
https://purehost.bath.ac.uk/ws/files/204588204/Cozier_et_al_Accepted_version_19_Mar_2020.pdf

Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb)

Autor: Lauren B. Arendse, Lizelle Lubbe, Sylva L. U. Schwager, Afolake T. Arowolo, Emma Ruth Belcher, Gyles E. Cozier, Edward D. Sturrock, K. Ravi Acharya

Publikováno v: The Biochemical journal. 476(10)

Angiotensin-converting enzyme (ACE) is a zinc metalloprotease best known for its role in blood pressure regulation. ACE consists of two homologous catalytic domains, the N- and C-domain, that display distinct but overlapping catalytic functions in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61169c441440cdf42218942b8d90a610
https://pubmed.ncbi.nlm.nih.gov/31072910