Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gyan Modi"'
Autor:
Magdalena Makowska-Grzyska, Youngchang Kim, Suresh Kumar Gorla, Yang Wei, Kavitha Mandapati, Minjia Zhang, Natalia Maltseva, Gyan Modi, Helena I Boshoff, Minyi Gu, Courtney Aldrich, Gregory D Cuny, Lizbeth Hedstrom, Andrzej Joachimiak
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0138976 (2015)
Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug resistant TB. Inosine 5'-monophosphate dehydrogenase 2 (IMPDH2) from Mycobacterium tuberculosis
Externí odkaz:
https://doaj.org/article/49962dbbbacf43ff908481f32290ecf0
Autor:
Himanshu Rai, Rishabh Singh, Prahalad Bharti, Prabhat Kumar, Sanskriti Rai, Tanmay Varma, Brijesh Singh Chauhan, Aishwarya Nilakhe, Joy Debnath, Vijay Mishra, Sarika Gupta, Sairam Krishnamurthy, Jian Yang, Prabha Garg, Saripella Srikris, Saroj Kumar, Gyan Modi
Molecular near-infrared (NIR) imaging is an emerging pre-clinical tool for labeling Alzheimer's disease (AD) pathogenic biomarkers, especially cerebral amyloid-beta (Aβ) plaques. Herein, we present a series of acceptor-π-donor based molecular NIR p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183ab4bc2441e0ce8003921cec30451f
https://doi.org/10.21203/rs.3.rs-2721179/v1
https://doi.org/10.21203/rs.3.rs-2721179/v1
Autor:
Rapelly Venkatesh, Gauri Shankar, Aswathi C. Narayanan, Gyan Modi, Shahulhameed Sabiah, Jeyakumar Kandasamy
Publikováno v:
The Journal of Organic Chemistry. 87:6730-6741
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f4c82fd87a6ca02408285f0861fbcf2
https://doi.org/10.1021/acs.joc.2c00423
https://doi.org/10.1021/acs.joc.2c00423
Autor:
Deviprasad R. Gollapalli, Gregory D. Cuny, Adhar C. Manna, Natalia Maltseva, Barry B. Snider, Yubo Zhang, Mohana Rao Vippila, Ann P. Lawson, Lizbeth Hedstrom, Minjia Zhang, Youngchang Kim, David M Rothstein, Shibin Chacko, Petr Kuzmic, Xingyou Wang, Andrzej Joachimiak, Ryan T Cullinane, Gyan Modi, Gary M Marqus, Ambrose L. Cheung, Judy L.M. Kotler
Publikováno v:
ACS Infectious Diseases. 7:3062-3076
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a38314a14bd8ed48fa872a866f2505
https://doi.org/10.1021/acsinfecdis.1c00342
https://doi.org/10.1021/acsinfecdis.1c00342
Autor:
Himanshu Rai, Sarika Gupta, Saroj Kumar, Jian Yang, Sushil K. Singh, Chongzhao Ran, Gyan Modi
Publikováno v:
Journal of medicinal chemistry. 65(13)
A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in the brain regions. Existing radiotracer diagnostic tools, such as PET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9c21ebd73365c9427cee6de033a015
https://pubmed.ncbi.nlm.nih.gov/35759679
https://pubmed.ncbi.nlm.nih.gov/35759679
Autor:
SAROJ KUMAR, SIMRAN RASTOGI, KOMAL RANI, SANSKRITI RAI, RISHABH SINGH, Vaibhav Sharma, PRAHALAD BHARTI, VRINDA KAPOOR, POORVI VISHWAKARMA, Shivaji Gholap, KRISHNA INAMPUDI, GYAN MODI, NEERJA RANI, MADHAVI TRIPATHI, ACHAL SRIVAST, ROOPA RAJAN, Fredrik Nikolajeff
Parkinson’s disease is generally asymptomatic at earlier stages. The pressing need is for the susceptibility risk biomarkers, that can aid in better diagnosis and therapeutics as well can objectively serve to measure the endpoint of disease progres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75c19a43892eb42d097a97883e42099f
https://doi.org/10.21203/rs.3.rs-1621589/v1
https://doi.org/10.21203/rs.3.rs-1621589/v1
Autor:
Rapelly, Venkatesh, Gauri, Shankar, Aswathi C, Narayanan, Gyan, Modi, Shahulhameed, Sabiah, Jeyakumar, Kandasamy
Publikováno v:
The Journal of organic chemistry. 87(10)
Multicomponent synthesis of biologically relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::909e9e58590f7d003c40fc9afa1d2db2
https://pubmed.ncbi.nlm.nih.gov/35545917
https://pubmed.ncbi.nlm.nih.gov/35545917
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:2878-2892
Alzheimer���s disease (AD) is one of the most familiar multifactorial and complex neurodegenerative disorders characterized by loss of cholinergic neurons in the brain. The various attempts for drug development to treat AD have been hampered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bb1cd24985b628617c592a3c37d391
https://doi.org/10.1080/07391102.2020.1844054
https://doi.org/10.1080/07391102.2020.1844054
Autor:
Gourav Singh, Prashant Kesharwani, Bhupendra Kumar, Indubhusan Mishra, Saroj Kumar, Gyan Modi
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f21fae5391333f31d88942918a67d63
https://doi.org/10.2139/ssrn.4091174
https://doi.org/10.2139/ssrn.4091174
Autor:
Gyan, Modi, Gary M, Marqus, Mohana Rao, Vippila, Deviprasad R, Gollapalli, Youngchang, Kim, Adhar C, Manna, Shibin, Chacko, Natalia, Maltseva, Xingyou, Wang, Ryan T, Cullinane, Yubo, Zhang, Judy L M, Kotler, Petr, Kuzmic, Minjia, Zhang, Ann P, Lawson, Andrzej, Joachimiak, Ambrose, Cheung, Barry B, Snider, David M, Rothstein, Gregory D, Cuny, Lizbeth, Hedstrom
Publikováno v:
ACS Infect Dis
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5’-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ad78a428808eb670c119d890ec480eb
https://pubmed.ncbi.nlm.nih.gov/34590817
https://pubmed.ncbi.nlm.nih.gov/34590817