Zobrazeno 1 - 10
of 97
pro vyhledávání: '"György Várady"'
Autor:
Gergely Attila Rácz, Nikolett Nagy, György Várady, József Tóvári, Ágota Apáti, Beáta G. Vértessy
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract In human cells two dUTPase isoforms have been described: one nuclear (DUT-N) and one mitochondrial (DUT-M), with cognate localization signals. In contrast, here we identified two additional isoforms; DUT-3 without any localization signal and
Externí odkaz:
https://doaj.org/article/3c62db1bbec842f69dc1d409652a918e
Autor:
Anna Pató, Kata Bölcskei, Ágnes Donkó, Diána Kaszás, Melinda Boros, Lilla Bodrogi, György Várady, Veronika F.S. Pape, Benoit T. Roux, Balázs Enyedi, Zsuzsanna Helyes, Fiona M. Watt, Gábor Sirokmány, Miklós Geiszt
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102670- (2023)
Keratinocytes of the mammalian skin provide not only mechanical protection for the tissues, but also transmit mechanical, chemical, and thermal stimuli from the external environment to the sensory nerve terminals. Sensory nerve fibers penetrate the e
Externí odkaz:
https://doaj.org/article/1c2265ef3af44926b8a13f251ef3f07b
Autor:
Anita Fehér, Andrea Schnúr, Suchitra Muenthaisong, Tamás Bellák, Ferhan Ayaydin, György Várady, Elisabeth Kemter, Eckhard Wolf, András Dinnyés
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Stem cell therapy has great potential for replacing beta-cell loss in diabetic patients. However, a key obstacle to cell therapy’s success is to preserve viability and function of the engrafted cells. While several strategies have been dev
Externí odkaz:
https://doaj.org/article/ef9de7a5d9d6400abedfcdb22e4b59c8
Autor:
Orsolya Mózner, Boglárka Zámbó, Zsuzsa Bartos, Anna Gergely, Kata Sára Szabó, Bálint Jezsó, Ágnes Telbisz, György Várady, László Homolya, Tamás Hegedűs, Balázs Sarkadi
Publikováno v:
Membranes, Vol 13, Iss 10, p 822 (2023)
The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this work, we have analyzed the effects of selected variants, r
Externí odkaz:
https://doaj.org/article/d2e751a0cf98473c95d382c7980d6546
Autor:
Krisztina Németh, Zsófia László, Adrienn Biró, Ágnes Szatmári, Gergely B. Cserép, György Várady, Éva Bakos, Csilla Özvegy-Laczka, Péter Kele
Publikováno v:
Molecules, Vol 28, Iss 6, p 2521 (2023)
Organic anion transporting polypeptides (OATPs) were found to readily deliver membrane impermeable, tetrazine bearing fluorescent probes into cells. This feature was explored in OATP3A1 conditioned bio-orthogonal labeling schemes of various intracell
Externí odkaz:
https://doaj.org/article/1e557f8d08924547a9447e7f05d09851
Autor:
Edit Szabó, Anna Kulin, László Korányi, Botond Literáti-Nagy, Judit Cserepes, Anikó Somogyi, Balázs Sarkadi, György Várady
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Type 2 diabetes mellitus (T2DM) is one of the most common multifactorial diseases and several membrane transporters are involved in its development, complications and treatment. We have recently developed a flow-cytometry assay panel for the
Externí odkaz:
https://doaj.org/article/e5369ce45b044a7c819cf6b39c05aeb1
Autor:
Tamás Langó, Zoltán Gergő Pataki, Lilla Turiák, András Ács, Julia Kornélia Varga, György Várady, Nóra Kucsma, László Drahos, Gábor E. Tusnády
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Transmembrane proteins (TMP) play a crucial role in several physiological processes. Despite their importance and diversity, only a few TMP structures have been determined by high-resolution protein structure characterization methods so far.
Externí odkaz:
https://doaj.org/article/59f84953b9054598b7843cb7e89e568f
Autor:
Dorottya Anna Simon, András Tálas, Péter István Kulcsár, Zsuzsanna Biczók, Sarah Laura Krausz, György Várady, Ervin Welker
Publikováno v:
eLife, Vol 11 (2022)
Prime editing is a recently developed CRISPR/Cas9 based gene engineering tool that allows the introduction of short insertions, deletions, and substitutions into the genome. However, the efficiency of prime editing, which typically achieves editing r
Externí odkaz:
https://doaj.org/article/2832519c90ae4f6380f0a4179e621568
Autor:
Anna Kulin, Nóra Kucsma, Balázs Bohár, Botond Literáti-Nagy, László Korányi, Judit Cserepes, Anikó Somogyi, Balázs Sarkadi, Edit Szabó, György Várady
Publikováno v:
Biology, Vol 11, Iss 11, p 1669 (2022)
The human GLUT1 (SLC2A1) membrane protein is the key glucose transporter in numerous cell types, including red cells, kidney, and blood-brain barrier cells. The expression level of this protein has a role in several diseases, including cancer and Alz
Externí odkaz:
https://doaj.org/article/7b05fdae17d44e46b15a56baf3d63ca9
Autor:
Flóra Vajda, Áron Szepesi, György Várady, Judit Sessler, Dániel Kiss, Zsuzsa Erdei, Kornélia Szebényi, Katalin Német, Gergely Szakács, András Füredi
Publikováno v:
Cells, Vol 11, Iss 19, p 2942 (2022)
Mesenchymal stem cells (MSCs) or fibroblasts are one of the most abundant cell types in the tumor microenvironment (TME) exerting various anti- and pro-apoptotic effects during tumorigenesis, invasion, and drug treatment. Despite the recently discove
Externí odkaz:
https://doaj.org/article/eb5c30478a804bf0acc38700970e4baf