Zobrazeno 1 - 7
of 7
pro vyhledávání: '"György István Túrós"'
Autor:
György Szabó, Minami Natsumi, Miklós Dékány, György István Túrós, István Greiner, Sándor Kolok, Zsuzsanna Sánta, Watanabe Tatsuya, Mónika Vastag, György Lévay, György M. Keserű
Publikováno v:
Journal of Medicinal Chemistry. 62:234-246
Metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulators (PAMs) have been implicated as potential pharmacotherapy for psychiatric conditions. Screening our corporate compound deck, we identified a benzotriazole fragment (4) that was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00684e8fb31100edea25a20f9acd005
https://doi.org/10.1021/acs.jmedchem.8b00161
https://doi.org/10.1021/acs.jmedchem.8b00161
Autor:
Róbert Örkényi, Ferenc Faigl, Péter Bana, János Éles, György István Túrós, Klára Lövei, Ágnes Lakó, István Greiner
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6180-6189
Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458904e2642cd20f5f76f96ef9ce8443
https://doi.org/10.1016/j.bmc.2016.12.046
https://doi.org/10.1016/j.bmc.2016.12.046
Autor:
Zoltán Béni, György István Túrós, János Kóti, Nóra Zsuzsa Kiss, István Greiner, Áron Szigetvári, Péter Bana, János Éles, Ágnes Lakó
Publikováno v:
Organic Process Research & Development. 21:611-622
A continuous-flow system consisting of two sequential microreactors was developed for the synthesis of nonsymmetrically substituted ureas starting from tert-butoxycarbonyl protected amines. Short reaction times could be achieved under mild conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24c0daeac3f6b8cf5818823913a7267b
https://doi.org/10.1021/acs.oprd.7b00019
https://doi.org/10.1021/acs.oprd.7b00019
Autor:
Péter Huszthy, György T. Balogh, Eszter Riethmüller, Eszter Rojik, Tamás Fődi, József Kupai, György István Túrós, Tamás Németh
Publikováno v:
Journal of Flow Chemistry. 6:297-301
This paper reports a new continuous-flow synthesis of chiral and achiral pyridino-18-crown-6 ethers. Macrocyclizations have been performed in a packed-bed flow reactor where deprotonation of a bifunctional primary or a secondary alcohol takes place w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec1eedf056f0acb6af0d65579e0c8f73
https://doi.org/10.1556/1846.2016.00033
https://doi.org/10.1556/1846.2016.00033
Autor:
Tamás Fődi, József Kupai, György István Túrós, István Greiner, György T. Balogh, Zoltán Béni, Gergő Ignácz, Balázs Decsi, Péter Huszthy, Diána Weiser
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 24(37)
A medium-throughput screening (MTS) of biomimetic drug metabolite synthesis is developed by using an iron porphyrin catalyst. The microplate method, in combination with HPLC-MS analysis, was shown to be a useful tool for process development and param
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fb7a3c7ee1ecdd6c51555dc512fe18
https://pubmed.ncbi.nlm.nih.gov/29736963
https://pubmed.ncbi.nlm.nih.gov/29736963
Autor:
Zoltán Novák, István Greiner, János Éles, György István Túrós, Klára Lövei, Áron Szigetvári, Miklós Dékány, Sándor Lévai
Publikováno v:
Journal of Flow Chemistry. 5:74-81
In medicinal chemistry, the development of synthetic procedures for the access of new heterocyclic systems as potential scaffolds is elementary. Herein, we report our results on the formation of small drug-like heterocycles, utilizing flow chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1d0920984bd16a9f4574dc16c589df6
https://doi.org/10.1556/1846.2015.00004
https://doi.org/10.1556/1846.2015.00004
Autor:
József Kupai, Tünde Tóth, Tamás Fődi, György T. Balogh, György István Túrós, Sándor Lévai, Tamás Németh, Péter Huszthy
Publikováno v:
Journal of Chromatographic Science. 53:431-435
This paper reports a novel method for the preparation of chiral stationary phases (CSPs) using an acridino-18-crown-6 ether selector as a model compound. Chiral stationary phase (R,R)-CSP- 2A: was obtained by in situ continuously recirculating the so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83730c18a7f3826a6cab89b2430fdc9
https://doi.org/10.1093/chromsci/bmu157
https://doi.org/10.1093/chromsci/bmu157