Zobrazeno 1 - 10
of 234
pro vyhledávání: '"György Hajnóczky"'
Publikováno v:
Contact, Vol 7 (2024)
Calcium signal propagation from endoplasmic reticulum (ER) to mitochondria regulates a multitude of mitochondrial and cell functions, including oxidative ATP production and cell fate decisions. Ca 2+ transfer is optimal at the ER-mitochondrial contac
Externí odkaz:
https://doaj.org/article/06c04454411f40e5b415f1a68288aa74
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/f936b837a1d54a6289c22e3d1b498066
Autor:
Aniko Gal, Peter Balicza, David Weaver, Shamim Naghdi, Suresh K Joseph, Péter Várnai, Tibor Gyuris, Attila Horváth, Laszlo Nagy, Erin L Seifert, Maria Judit Molnar, György Hajnóczky
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/05870890e3114cd0a1ae734c6b71f1e0
Autor:
Máté Katona, Ádám Bartók, Zuzana Nichtova, György Csordás, Elena Berezhnaya, David Weaver, Arijita Ghosh, Péter Várnai, David I. Yule, György Hajnóczky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The formation and dissolution of ER-Mitochondria contacts is unclear. Here, authors show that the IP3 receptor traffics in and out of the contacts and, when trapped, improves calcium signaling to stimulate energy metabolism.
Externí odkaz:
https://doaj.org/article/89e82e0994884eee859938e0f2c594f8
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101119- (2022)
Summary: This protocol describes how to visualize, detect, and analyze redox signals (oxidative bursts) at the ER-mitochondrial interface. It uses drug-inducible crosslinking to target the genetically encoded glutathione redox sensor Grx1roGFP2 to or
Externí odkaz:
https://doaj.org/article/1134d342c13544f2a7b3b44d93ce631f
Autor:
Benjamín Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, María E. Andrés, Patrick Yu-Wai-Man, György Hajnóczky, Verónica Eisner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cristae organ
Externí odkaz:
https://doaj.org/article/6834c9fb16f84d8d8f1c69b4915ab777
Autor:
Alyssa A. Lombardi, Andrew A. Gibb, Ehtesham Arif, Devin W. Kolmetzky, Dhanendra Tomar, Timothy S. Luongo, Pooja Jadiya, Emma K. Murray, Pawel K. Lorkiewicz, György Hajnóczky, Elizabeth Murphy, Zoltan P. Arany, Daniel P. Kelly, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of t
Externí odkaz:
https://doaj.org/article/bdc7ccfd4f494ac28c7dce1cb6b33f83
Autor:
Adam Bartok, David Weaver, Tünde Golenár, Zuzana Nichtova, Máté Katona, Száva Bánsághi, Kamil J. Alzayady, V. Kaye Thomas, Hideaki Ando, Katsuhiko Mikoshiba, Suresh K. Joseph, David I. Yule, György Csordás, György Hajnóczky
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural
Externí odkaz:
https://doaj.org/article/573c9a6e3c934f97817996bbe29c011b
Autor:
Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, Maya Schuldiner
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Given the recent growing interest in interorganelle membrane contact sites, the field will benefit from clear rules to define and study them. In this Perspective, a panel of experts aims to provide this growing field with guidelines for experimental
Externí odkaz:
https://doaj.org/article/5394a31700dd4930b680e3b555969840
Autor:
Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, Narayan G. Avadhani
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101370- (2020)
Summary: This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca2+ in the cytoplasm
Externí odkaz:
https://doaj.org/article/924abfb694954dbebaa357b1e2bbaf5d