Investigation of the Experimental Pharmacokinetics of the Bis-Chlorinated Bis-pyridinium Mono-aldoxime Cholinesterase Reactivator K-868 in Rats

Autor: Huba Kalász, Kornélia Tekes, György Bátor, Jennifer Adeghate, Ernest Adeghate, Ferenc Darvas, József Fűrész, Gellért Karvaly

Publikováno v: The Open Medicinal Chemistry Journal. 15:17-27

Background: The widespread use of organophosphorus compounds in agriculture and their existence in some military arsenals present continuous threats. Quaternary bis-pyridinium aldoximes are potent, highly polar cholinesterase reactivators and the mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11e44ec204501f6a78b5cd3a71491501
https://doi.org/10.2174/1874104502015010017

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1)

Autor: Felipe A. Medeiros, Thomas R. Walters, Miriam Kolko, Michael Coote, Marina Bejanian, Margot L. Goodkin, Qiang Guo, Jane Zhang, Michael R. Robinson, Robert N. Weinreb, Ashish Agar, Renuka Bathijia, Lance Liu, Tim Roberts, Christoph Faschinger, Clemens Vass, Nathalie Collignon, Ana Claudia Alves Pereira, Rubens Belfort de Mattos, Fernando Justino Dantas, Marcelo Jordao Lopes da Silva, Fabio Kanadani, Leopoldo Magacho dos Santos Silva, Tiago Prata, Daniella Bach-Holm, Jimmy Lai, Clement Tham, György Bátor, Lajos Szalczer, Balázs Varsányi, Eytan Blumenthal, Orna Geyer, Shmuel Lavartovsky, Tamar Pedut-Kloizman, Nir Shoham-Hazon, Silvio Lujan, Benjamin Abela, Robert E. Ang, Edgar U. Leuenberger, Harvey Uy, Maria Imelda Yap-Veloso, Piotr Fryczkowski, Piotr Jurowski, Bartlomiej Kalużny, Józef Kalużny, Marta Misiuk-Hojlo, Krystyna Raczynska, Wioletta Tomczyk-Dorozynska, Jaromir Wasyluk, Slawomir Zalewski, Tomasz Zarnowski, Julian Garcia Feijoó, Rafael Giménez-Gómez, Elena Milla Griño, Alfonso Antón López, Merce Guarro Miralles, Javier Montero Moreno, Vicente Polo, Enrique Cervera Taulet, Beatriz Ponte Zúñiga, Ying-Ying Chen, Yuan-Chieh Lee, Louis Alpern, Michael S. Berlin, Jacob Brubaker, Delmar Caldwell, Andrew Camp, Louis B. Cantor, Ronald Caronia, Charles J. Crane, Douglas Day, Eran Duzman, John Elfervig, Sherif El-Harazi, Richard Evans, Ann C. Fisher, William John Flynn, Charles Stephen Foster, Ronald Frenkel, Raj Goyal, Ronald Gross, Paul J. Hartman, William L. Haynes, Gary Jerkins, Janet Kim, Max Kim, Bradley Kwapiszeski, Benjamin Lambright, Christine Larsen, James Lehmann, Jeffrey H. Levenson, Dwayne Logan, Brian McMillan, Joseph R. Martel, Hylton Mayer, Felipe Medeiros, Sayoko Moroi, Andrew Moyes, Jonathan Myers, John Nairn, Steven Nielsen, Don Perez Ortiz, James Paauw, Vicky Pai, Joseph Panarelli, Abraham Park, Mujtaba A. Qazi, Nikola Ragusa, Douglas J. Rhee, Robert Rothman, Reginald Sampson, Samuel Seltzer, Anurag Shrivastava, Steven T. Simmons, Annette Sims, Mark A. Slabaugh, Scott Smetana, Oluwatosin Smith, Scott C. So, Ingeborg Stalmans, Jitendra Swarup, Jay Wallshein, Fiaz Zaman, Rui Zhang

Publikováno v: Medeiros, F A, Walters, T R, Kolko, M, Coote, M, Bejanian, M, Goodkin, M L, Guo, Q, Zhang, J, Robinson, M R, Weinreb, R N, ARTEMIS 1 Study Group, Agar, A, Coote, M, Bathijia, R, Bach-Holm, D, Walters, T R, Zaman, F & Zhang, R 2020, ' Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1) ', Ophthalmology, vol. 127, no. 12, pp. 1627-1641 . https://doi.org/10.1016/j.ophtha.2020.06.018

Purpose To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations. Design Randomiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6460ae378d48f231ab7646dd34d2e2a
https://pubmed.ncbi.nlm.nih.gov/32544560

[Endogenous nociceptin level in ischemic stroke: connection to serotonin system]

Autor: Kornélia, Tekes, Mónika, Hantos, György, Bátor, Melinda, Gyenge, Rudolf, Laufer, András, Folyovich

Publikováno v: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. 8(2)

Particular role of the heptadecapeptide nociceptin (orphanin FQ), the endogenous agonist of the NOP receptor, has been widely demonstrated in the regulation of pain sensation and anxiety-related behavior. In our best knowledge this is the first study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ae316ac1886464ce362dd9d9163083f
https://pubmed.ncbi.nlm.nih.gov/17073212