Zobrazeno 1 - 10
of 174
pro vyhledávání: '"György, Vereb"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CAR T cell therapies face challenges in combating solid tumors due to their single-target approach, which becomes ineffective if the targeted antigen is absent or lost. Universal CAR T cells (UniCAR Ts) provide a promising solution by utilizing molec
Externí odkaz:
https://doaj.org/article/a8964f6b110844eb8baf8db59068311f
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5978 (2024)
Pertuzumab (Perjeta®), a humanized antibody binding to the dimerization arm of HER2 (Human epidermal growth factor receptor-2), has failed as a monotherapy agent in HER2 overexpressing malignancies. Since the molecular interaction of HER2 with ligan
Externí odkaz:
https://doaj.org/article/a2a5e827a61d475ba64d4632cf169a89
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The actual interaction between signaling species in cellular processes is often more important than their expression levels. Förster resonance energy transfer (FRET) is a popular tool for studying molecular interactions, since it is highly
Externí odkaz:
https://doaj.org/article/01884f0f40104be2a06fe74f594bcc64
Autor:
Markus Barden, Astrid Holzinger, Lukas Velas, Marianna Mezősi-Csaplár, Árpád Szöőr, György Vereb, Gerhard J. Schütz, Andreas A. Hombach, Hinrich Abken
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In engineered T cells the CAR is co-expressed along with the physiological TCR/CD3 complex, both utilizing the same downstream signaling machinery for T cell activation. It is unresolved whether CAR-mediated T cell activation depends on the presence
Externí odkaz:
https://doaj.org/article/e06e8704a97446f89d093d4b3e77ab95
Publikováno v:
Cancers, Vol 15, Iss 12, p 3081 (2023)
Chimeric antigen receptor (CAR)-modified T cells brought a paradigm shift in the treatment of chemotherapy-resistant lymphomas. Conversely, clinical experience with CAR T cells targeting solid tumors has been disheartening, indicating the necessity o
Externí odkaz:
https://doaj.org/article/c7d4f298fe824d77996940397d8e8c5a
Autor:
Mihály Cserepes, Györgyi A. Nelhűbel, Mónika Meilinger-Dobra, Adrienn Herczeg, Dóra Türk, Zita Hegedűs, Laura Svajda, Erzsébet Rásó, Andrea Ladányi, Kristóf György Csikó, István Kenessey, Árpád Szöőr, György Vereb, Éva Remenár, József Tóvári
Publikováno v:
Cancers, Vol 14, Iss 10, p 2407 (2022)
Background: Head and neck squamous cell carcinomas (HNSCCs) are among the most abundant malignancies worldwide. Patients with recurrent/metastatic disease undergo combination chemotherapy containing cetuximab, the monoclonal antibody used against the
Externí odkaz:
https://doaj.org/article/a59970b185b4400398ff2c64091f80a3
Autor:
István Rebenku, Ferenc A. Bartha, Tamás Katona, Barbara Zsebik, Géza Antalffy, Lili Takács, Béla Molnár, György Vereb
Publikováno v:
Cytometry Part A. 103:198-207
The emergence and fast advance of digital pathology allows the acquisition, digital storage, interactive recall and analysis of morphology at the tissue level. When applying immunohistochemistry, it also affords the correlation of morphology with the
Publikováno v:
Cancers, Vol 13, Iss 17, p 4301 (2021)
Correlative studies of clinical studies for hematological malignancies have implicated that less differentiated, CD8+-dominant CAR T cell products have greater antitumor activity. Here, we have investigated whether the differentiation status of CAR T
Externí odkaz:
https://doaj.org/article/a8d122ea9c434059bfed0b5e4bf79ad4
Autor:
Ágnes Angyal, Zsófia Pénzes, Shahrzad Alimohammadi, Dorottya Horváth, Lili Takács, György Vereb, Barbara Zsebik, Tamás Bíró, Kinga Fanni Tóth, Erika Lisztes, Balázs István Tóth, Attila Oláh, Attila Gábor Szöllősi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7776 (2021)
Photodamage-induced and viral keratitis could benefit from treatment with novel nonsteroid anti-inflammatory agents. Therefore, we determined whether human corneal epithelial cells (HCECs) express members of the endocannabinoid system (ECS), and exam
Externí odkaz:
https://doaj.org/article/8e95e31e8be94b9089f9467c1e28a25e
Autor:
Eliza Guti, Zsolt Regdon, Isotta Sturniolo, Alexandra Kiss, Katalin Kovács, Máté Demény, Árpád Szöőr, György Vereb, János Szöllősi, Csaba Hegedűs, Zsuzsanna Polgár, László Virág
Publikováno v:
Cancer Immunology, Immunotherapy. 71:2151-2168
Despite recent advances in the development of novel personalized therapies, breast cancer continues to challenge physicians with resistance to various advanced therapies. The anticancer action of the anti-HER2 antibody, trastuzumab, involves antibody