Zobrazeno 1 - 10 of 245 pro vyhledávání: '"György, Vereb"'
1
Akademický článek
Universal CAR T cells targeted to HER2 with a biotin-trastuzumab soluble linker penetrate spheroids and large tumor xenografts that are inherently resistant to trastuzumab mediated ADCC
Autor: Lőrinc Nagy, Marianna Mezősi-Csaplár, István Rebenku, György Vereb, Árpád Szöőr
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
CAR T cell therapies face challenges in combating solid tumors due to their single-target approach, which becomes ineffective if the targeted antigen is absent or lost. Universal CAR T cells (UniCAR Ts) provide a promising solution by utilizing molec
Externí odkaz: https://doaj.org/article/a8964f6b110844eb8baf8db59068311f
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2
Akademický článek
Pixel-by-pixel autofluorescence corrected FRET in fluorescence microscopy improves accuracy for samples with spatially varied autofluorescence to signal ratio
Autor: István Rebenku, Cameron B. Lloyd, János Szöllősi, György Vereb
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The actual interaction between signaling species in cellular processes is often more important than their expression levels. Förster resonance energy transfer (FRET) is a popular tool for studying molecular interactions, since it is highly
Externí odkaz: https://doaj.org/article/01884f0f40104be2a06fe74f594bcc64
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3
Akademický článek
CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation
Autor: Markus Barden, Astrid Holzinger, Lukas Velas, Marianna Mezősi-Csaplár, Árpád Szöőr, György Vereb, Gerhard J. Schütz, Andreas A. Hombach, Hinrich Abken
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
In engineered T cells the CAR is co-expressed along with the physiological TCR/CD3 complex, both utilizing the same downstream signaling machinery for T cell activation. It is unresolved whether CAR-mediated T cell activation depends on the presence
Externí odkaz: https://doaj.org/article/e06e8704a97446f89d093d4b3e77ab95
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4
Taking molecular pathology to the next level: Whole slide multicolor confocal imaging with the Pannoramic Confocal digital pathology scanner
Autor: István Rebenku, Ferenc A. Bartha, Tamás Katona, Barbara Zsebik, Géza Antalffy, Lili Takács, Béla Molnár, György Vereb
Publikováno v: Cytometry Part A. 103:198-207
The emergence and fast advance of digital pathology allows the acquisition, digital storage, interactive recall and analysis of morphology at the tissue level. When applying immunohistochemistry, it also affords the correlation of morphology with the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb9e5cfe3e35692d1bfdf5a58734ec3
https://doi.org/10.1002/cyto.a.24675
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5
The multitargeted receptor tyrosine kinase inhibitor sunitinib induces resistance of HER2 positive breast cancer cells to trastuzumab-mediated ADCC
Autor: Eliza Guti, Zsolt Regdon, Isotta Sturniolo, Alexandra Kiss, Katalin Kovács, Máté Demény, Árpád Szöőr, György Vereb, János Szöllősi, Csaba Hegedűs, Zsuzsanna Polgár, László Virág
Publikováno v: Cancer Immunology, Immunotherapy. 71:2151-2168
Despite recent advances in the development of novel personalized therapies, breast cancer continues to challenge physicians with resistance to various advanced therapies. The anticancer action of the anti-HER2 antibody, trastuzumab, involves antibody
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e7173a2fcb41cee1e952156f5b093e
https://doi.org/10.1007/s00262-022-03146-z
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7
EGFR R521K Polymorphism Is Not a Major Determinant of Clinical Cetuximab Resistance in Head and Neck Cancer
Autor: Mihály Cserepes, Györgyi A. Nelhűbel, Mónika Meilinger-Dobra, Adrienn Herczeg, Dóra Türk, Zita Hegedűs, Laura Svajda, Erzsébet Rásó, Andrea Ladányi, Kristóf György Csikó, István Kenessey, Árpád Szöőr, György Vereb, Éva Remenár, József Tóvári
Publikováno v: Cancers; Volume 14; Issue 10; Pages: 2407
Background: Head and neck squamous cell carcinomas (HNSCCs) are among the most abundant malignancies worldwide. Patients with recurrent/metastatic disease undergo combination chemotherapy containing cetuximab, the monoclonal antibody used against the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490244a9d10a8cdec4a3984bcd034571
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9
Use of red, far-red, and near-infrared light in imaging of yeasts and filamentous fungi
Autor: István Pócsi, Zsuzsa M. Szigeti, Tamás Emri, Imre Boczonádi, György Vereb, János Szöllősi
Publikováno v: Applied microbiology and biotechnology. 106(11)
Abstract While phototoxicity can be a useful therapeutic modality not only for eliminating malignant cells but also in treating fungal infections, mycologists aiming to observe morphological changes or molecular events in fungi, especially when long
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef33a9c47b204ec5d31e05a30c51cb8
https://pubmed.ncbi.nlm.nih.gov/35599256
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10
Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models
Autor: Marianna, Csaplár, János, Szöllősi, Stephen, Gottschalk, György, Vereb, Árpád, Szöőr
Publikováno v: Cancers
Volume 13
Issue 17
Cancers, Vol 13, Iss 4301, p 4301 (2021)
Correlative studies of clinical studies for hematological malignancies have implicated that less differentiated, CD8+-dominant CAR T cell products have greater antitumor activity. Here, we have investigated whether the differentiation status of CAR T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3b04cc59e309dbe1ba5b182c67ef458c
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