Zobrazeno 1 - 10
of 103
pro vyhledávání: '"György, Csordás"'
Publikováno v:
Contact, Vol 7 (2024)
Calcium signal propagation from endoplasmic reticulum (ER) to mitochondria regulates a multitude of mitochondrial and cell functions, including oxidative ATP production and cell fate decisions. Ca 2+ transfer is optimal at the ER-mitochondrial contac
Externí odkaz:
https://doaj.org/article/06c04454411f40e5b415f1a68288aa74
Autor:
Máté Katona, Ádám Bartók, Zuzana Nichtova, György Csordás, Elena Berezhnaya, David Weaver, Arijita Ghosh, Péter Várnai, David I. Yule, György Hajnóczky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The formation and dissolution of ER-Mitochondria contacts is unclear. Here, authors show that the IP3 receptor traffics in and out of the contacts and, when trapped, improves calcium signaling to stimulate energy metabolism.
Externí odkaz:
https://doaj.org/article/89e82e0994884eee859938e0f2c594f8
Autor:
Adam Bartok, David Weaver, Tünde Golenár, Zuzana Nichtova, Máté Katona, Száva Bánsághi, Kamil J. Alzayady, V. Kaye Thomas, Hideaki Ando, Katsuhiko Mikoshiba, Suresh K. Joseph, David I. Yule, György Csordás, György Hajnóczky
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural
Externí odkaz:
https://doaj.org/article/573c9a6e3c934f97817996bbe29c011b
Autor:
Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, Narayan G. Avadhani
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101370- (2020)
Summary: This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca2+ in the cytoplasm
Externí odkaz:
https://doaj.org/article/924abfb694954dbebaa357b1e2bbaf5d
Autor:
Melanie Paillard, György Csordás, Gergö Szanda, Tünde Golenár, Valentina Debattisti, Adam Bartok, Nadan Wang, Cynthia Moffat, Erin L. Seifert, András Spät, György Hajnóczky
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2291-2300 (2017)
Mitochondrial Ca2+ uptake through the Ca2+ uniporter supports cell functions, including oxidative metabolism, while meeting tissue-specific calcium signaling patterns and energy needs. The molecular mechanisms underlying tissue-specific control of th
Externí odkaz:
https://doaj.org/article/74bcc08031334f4fbefb96b73971341a
Autor:
Zuzana Nichtová, Celia Fernandez-Sanz, Sergio De La Fuente, Yuexing Yuan, Stephen Hurst, Sebastian Lanvermann, Hui-Ying Tsai, David Weaver, Ariele Baggett, Christopher Thompson, Cedric Bouchet-Marquis, Péter Várnai, Erin L. Seifert, Gerald W. Dorn, Shey-Shing Sheu, György Csordás
Publikováno v:
Circulation Research. 132
Background: Cardiac contractile function requires high energy from mitochondria, and Ca 2+ from the sarcoplasmic reticulum (SR). Via local Ca 2+ transfer at close mitochondria-SR contacts, cardiac excitation feedforward regulates mitochondrial ATP pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ac62ba01fb0bbbb448770307a52e7d
https://doi.org/10.1161/circresaha.122.321833
https://doi.org/10.1161/circresaha.122.321833
Autor:
Macarena Rodríguez-Prados, Kai-Ting Huang, Katalin Márta, Melanie Paillard, György Csordás, Suresh K. Joseph, György Hajnóczky
Publikováno v:
Cell Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::957dfbf741acd260e2048f2b7a63d6b1
https://doi.org/10.1016/j.chembiol.2023.05.002
https://doi.org/10.1016/j.chembiol.2023.05.002
Autor:
Anil Noronha Antony, Melanie Paillard, Cynthia Moffat, Egle Juskeviciute, Jason Correnti, Brad Bolon, Emanuel Rubin, György Csordás, Erin L. Seifert, Jan B. Hoek, György Hajnóczky
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium ov
Externí odkaz:
https://doaj.org/article/b517a4d3792f4bae85feef95db236c74
Autor:
Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T. Clements, Jin O-Uchi, György Csordás, Bum-Rak Choi, Dmitry Terentyev
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
In a physiological setting, mitochondria increase oxidative phosphorylation during periods of stress to meet increased metabolic demand. This in part is mediated via enhanced mitochondrial Ca2+ uptake, an important regulator of cellular ATP homeostas
Externí odkaz:
https://doaj.org/article/afd9fd2a470d40ac8bbdb50a6b5dfb09
Autor:
Sergio De La Fuente, Jonathan P. Lambert, Zuzana Nichtova, Celia Fernandez Sanz, John W. Elrod, Shey-Shing Sheu, György Csordás
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3099-3107.e4 (2018)
Summary: Mitochondrial Ca2+ elevations enhance ATP production, but uptake must be balanced by efflux to avoid overload. Uptake is mediated by the mitochondrial Ca2+ uniporter channel complex (MCUC), and extrusion is controlled largely by the Na+/Ca2+
Externí odkaz:
https://doaj.org/article/84a912c7503a491c8bfc9d16084ca19c