Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gwynne Roth"'
Autor:
Joanna Ireland, Jason Segura, Genbin Shi, Julianna Buchwald, Gwynne Roth, Thomas Juncheng Shen, Ruipeng Wang, Xinhua Ji, Elizabeth R. Fischer, Susan Moir, Tae-Wook Chun, Peter D. Sun
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
HIV-1 gp120 glycan binding to C-type lectin adhesion receptor L-selectin/CD62L on CD4 T cells facilitates viral attachment and entry. Paradoxically, the adhesion receptor impedes HIV-1 budding from infected T cells and the viral release requires the
Externí odkaz:
https://doaj.org/article/d1345b938a9e4d4b9d8558446242fdc7
Autor:
Rachel Erickson, Chang Huang, Cameron Allen, Joanna Ireland, Gwynne Roth, Zhongcheng Zou, Jinghua Lu, Bernard A. P. Lafont, Nicole L. Garza, Beniah Brumbaugh, Ming Zhao, Motoshi Suzuki, Lisa Olano, Joseph Brzostowski, Elizabeth R. Fischer, Homer L. Twigg, Reed F. Johnson, Peter D. Sun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Severe COVID-associated lung injury is a major confounding factor of hospitalizations and death with no effective treatments. Here, we describe a non-classical fibrin clotting mechanism mediated by SARS-CoV-2 infected primary lung but not ot
Externí odkaz:
https://doaj.org/article/dfb1e8c9aa3047e59958ec0f9d7a69ea
Autor:
Jason Segura, Joanna Ireland, Zhongcheng Zou, Gwynne Roth, Julianna Buchwald, Thomas J Shen, Elizabeth Fischer, Susan Moir, Tae-Wook Chun, Peter D Sun
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281087 (2023)
HIV infection remains incurable to date and there are no compounds targeted at the viral release. We show here HIV viral release is not spontaneous, rather requires caspases activation and shedding of its adhesion receptor, CD62L. Blocking the caspas
Externí odkaz:
https://doaj.org/article/db16d094b4b9452b932e1d4929bc1688
Autor:
Jason Segura, Biao He, Joanna Ireland, Zhongcheng Zou, Thomas Shen, Gwynne Roth, Peter D. Sun
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface. This glycan canopy is thought to primarily shield the virus from host immune recognition as glycans are poor immunogens i
Externí odkaz:
https://doaj.org/article/0f1f411fe52949b2bc8c18611a1edc13
Autor:
Biao He, Zhongcheng Zou, Joanna Ireland, Gwynne Roth, Peter D. Sun, Jason Segura, Thomas C. Shen
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 12 (2021)
Frontiers in Microbiology, Vol 12 (2021)
HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface. This glycan canopy is thought to primarily shield the virus from host immune recognition as glycans are poor immunogens i
Autor:
Susan Moir, Lela Kardava, Peter D. Sun, Yuxing Li, J. Shawn Justement, Kathleen R. Gittens, Wei Wang, Richard Kwan, Valerie A. Melson, Gwynne Roth, Marissa A. Hand, James W. Austin, Clarisa M. Buckner, Haewon Sohn, Christine Youn, Michael C. Sneller, Tae-Wook Chun, Susan K. Pierce
Immunoglobulin G3 (IgG3) has an uncertain role in the response to infection with and vaccination against human immunodeficiency virus (HIV). Here we describe a regulatory role for IgG3 in dampening the immune system–activating effects of chronic HI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c81c6c580eff8d7fb3ea246a8eeb8b
https://europepmc.org/articles/PMC6289069/
https://europepmc.org/articles/PMC6289069/
Autor:
Kate M. Rahbari, Haley A. Brown, Peter D. Sun, Genevieve Holzapfel, Joanna Ireland, Zhongcheng Zou, Sarek A. Shen, Gwynne Roth
Publikováno v:
Protein Expression and Purification. 105:8-13
We have previously developed a glutamine synthetase (GS)-based mammalian recombinant protein expression system that is capable of producing 5–30 mg/L recombinant proteins. The over expression is based on multiple rounds of target gene amplification