Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gwynn Pardee"'
Autor:
Xiaolei Ma, Barbara Leon, Elizabeth Ornelas, Dustin Dovala, Laura Tandeske, Catherine Luu, Gwynn Pardee, Stephania Widger, Jonathan M. Solomon, Rohan E. J. Beckwith, Heinz Moser, Matthew C. Clifton, Charles A. Wartchow
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract The design of cereblon-binding molecular glues (MGs) that selectively recruit a desired protein while excluding teratogenic SALL4 is an area of significant interest when designing therapeutic agents. Previous studies show that SALL4 is degra
Externí odkaz:
https://doaj.org/article/9ec871d57f274caeacf1b5e0701bf9f6
Autor:
Johanna M Jansen, Charles Wartchow, Wolfgang Jahnke, Susan Fong, Tiffany Tsang, Keith Pfister, Tatiana Zavorotinskaya, Dirksen Bussiere, Jan Marie Cheng, Kenneth Crawford, Yumin Dai, Jeffrey Dove, Eric Fang, Yun Feng, Jean-Michel Florent, John Fuller, Alvar D Gossert, Mohammad Hekmat-Nejad, Chrystèle Henry, Julia Klopp, William P Lenahan, Andreas Lingel, Sylvia Ma, Arndt Meyer, Yuji Mishina, Jamie Narberes, Gwynn Pardee, Savithri Ramurthy, Sebastien Rieffel, Darrin Stuart, Sharadha Subramanian, Laura Tandeske, Stephania Widger, Armin Widmer, Aurelie Winterhalter, Isabel Zaror, Stephen Hardy
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated
Externí odkaz:
https://doaj.org/article/935bc8e9e098406ea024047d133a1803
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Supplementary Figure 4. Growth of individual tumors shown in Fig. 7A-C are given for HCT 116 (A), MIA PaCa-2 (B) and MEL-JUSO (C) cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2175679541bcf9cea1bfe131eae3dc26
https://doi.org/10.1158/1078-0432.22480680
https://doi.org/10.1158/1078-0432.22480680
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
p-ERK MSD results in RAS mutant cells ectopically expressed ARAF variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a06d1625834f006100db5b3daf5cfda
https://doi.org/10.1158/1078-0432.22480659
https://doi.org/10.1158/1078-0432.22480659
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Purpose:Targeting RAF for antitumor therapy in RAS-mutant tumors holds promise. Herein, we describe in detail novel properties of the type II RAF inhibitor, LXH254.Experimental Design:LXH254 was profiled in biochemical, in vitro, and in vivo assays,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d1b1fef6c36ab7ea76ff43f5c11d34
https://doi.org/10.1158/1078-0432.c.6530499.v1
https://doi.org/10.1158/1078-0432.c.6530499.v1
Autor:
Giordano Caponigro, Vesselina G. Cooke, Darrin D. Stuart, Jeffrey A. Engelman, Peter S. Hammerman, Stephania Widger, Gwynn Pardee, Kenneth Crawford, John Fuller, Mariela Jaskelioff, Lesley Griner, Felipa Mapa, Jessi Ambrose, Peter Aspesi, John Green, Karen Bui, Jinsheng Liang, Hui Qin Wang, Stacy Higgins, Ribo Guo, Daniel McKay, Emma Labrot, Paul Fordjour, Yuji Mishina, Jing Yuan, Scott Delach, Kelli-Ann Monaco
Supplementary Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703cf919309a8d21ff2ef43d79a39ca5
https://doi.org/10.1158/1078-0432.22480674.v1
https://doi.org/10.1158/1078-0432.22480674.v1
Autor:
Peter S. Hammerman, Jing Yuan, Lesley A. Mathews Griner, Peter Aspesi, Daniel J. McKay, Gwynn Pardee, Hui Qin Wang, Kelli-Ann Monaco, Ribo Guo, Kenneth Crawford, Stephania Widger, Darrin Stuart, Vesselina G. Cooke, Karen Bui, Felipa A. Mapa, Yuji Mishina, Mariela Jaskelioff, Jeffrey A. Engelman, Paul Fordjour, Emma Labrot, Giordano Caponigro, Stacy Higgins, Jessi Ambrose, John Fuller, Jinsheng Liang, John Green, Scott Delach
Publikováno v:
Clinical Cancer Research. 27:2061-2073
Purpose: Targeting RAF for antitumor therapy in RAS-mutant tumors holds promise. Herein, we describe in detail novel properties of the type II RAF inhibitor, LXH254. Experimental Design: LXH254 was profiled in biochemical, in vitro, and in vivo assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75aeeab439f64334a9ace3edb9d3a375
https://doi.org/10.1158/1078-0432.ccr-20-2563
https://doi.org/10.1158/1078-0432.ccr-20-2563
Autor:
Patrick H.N. Celie, Georg Huber, Christian Benda, Anita Lehner, Hüseyin Besir, Cindy Chang, Paola Storici, Peggy Stolt-Bergner, Joop van den Heuvel, Astrid Sander, Gwynn Pardee, Sabine Suppmann, Regis P. Lemaitre, Barbara Giabbai, Wolfgang Knecht, Isabel Zaror, Daniel Weinbruch, Linda H.L. Lua, Tim Bergbrede, Ines Racke, Judith Scholz, David N. Drechsel, Arie Geerlof, Magda Stadnik, Ariane Fischer, Kristina Nordén, Kim Remans
Publikováno v:
J. Struct. Biol. 203, 71-80 (2018)
Baculovirus-insect cell expression system has become one of the most widely used eukaryotic expression systems for heterologous protein production in many laboratories. The availability of robust insect cell lines, serum-free media, a range of vector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ca00a22d4e1f9346a9509793321a5c
https://doi.org/10.1016/j.jsb.2018.03.004
https://doi.org/10.1016/j.jsb.2018.03.004
Autor:
Isabel Zaror, Kenneth Crawford, Mohammad Hekmat-Nejad, Stephania Widger, Janet Sim, Hanne Merritt, Kelly Yan, Gwynn Pardee, Jan Marie Cheng
Publikováno v:
Protein Expression and Purification. 110:172-179
Extracellular signal-regulated kinase 2 (ERK2) is a serine/threonine protein kinase involved in many cellular programs, such as cell proliferation, differentiation, motility and programed cell-death. It is therefore considered an important target in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1157838202e0204f1849084f6bd4179
https://doi.org/10.1016/j.pep.2015.03.010
https://doi.org/10.1016/j.pep.2015.03.010
Autor:
Johanna M. Jansen, Yipin Lu, Albert Lai, Isabel Zaror, Michael Doyle, Gwynn Pardee, Dirksen E. Bussiere, Sylvia Ma, Robert Elling, Kenneth Crawford, Janet Sim, Mulugeta Mamo, Yue Pan, Mark Knapp, Paul A. Barsanti, Kelly Yan, Elizabeth Ornelas, Warne Robert L, Li Zhang
Publikováno v:
Journal of molecular biology. 429(11)
ATR, a protein kinase in the PIKK family, plays a critical role in the cell DNA-damage response and is an attractive anticancer drug target. Several potent and selective inhibitors of ATR have been reported showing significant antitumor efficacy, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5068d5a04ae8326ba31df3c5b2b21376
https://pubmed.ncbi.nlm.nih.gov/28433539
https://pubmed.ncbi.nlm.nih.gov/28433539