Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gwyneth Welch"'
Autor:
Easwaran Ramamurthy, Gwyneth Welch, Jemmie Cheng, Yixin Yuan, Laura Gunsalus, David A. Bennett, Li-Huei Tsai, Andreas R. Pfenning
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and without Alzheimer’s Disease (AD). We confirm that single nucleotide polymo
Externí odkaz:
https://doaj.org/article/ceb332e45eeb48778b5b9d9ca1cfaaef
Autor:
Li-Huei Tsai, Gwyneth Welch
Publikováno v:
EMBO reports. 23
Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f92f4d9fc2d816e7852193ffd231420
https://doi.org/10.15252/embr.202154217
https://doi.org/10.15252/embr.202154217
Autor:
Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsai
SummaryApolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing late- onset Alzheimer’s disease and its expression in microglia is associated with pro- inflammatory states. How the interaction of APOE4 microglia with neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e65379af953ea122df84bcbf9fcdeb2
https://doi.org/10.1101/2022.03.21.484146
https://doi.org/10.1101/2022.03.21.484146
Autor:
Gwyneth Welch, Carles Boix, Eloi Schmauch, Jose Davila-Velderrain, Matheus B. Victor, Vishnu Dileep, Lorenzo Bozzelli, Qiao Su, Jemmie Cheng, Audrey Lee, Noelle Leary, Andreas Pfenning, Manolis Kellis, Li-Huei Tsai
DNA double strand breaks (DSBs) are linked to aging, neurodegeneration, and senescence1,2. However, the role played by neurons burdened with DSBs in disease-associated neuroinflammation is not well understood. Here, we isolate neurons harboring DSBs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f75198fd9deae4fd1c2934c9a6fef54
https://doi.org/10.1101/2021.12.23.474002
https://doi.org/10.1101/2021.12.23.474002