Výsledky vyhledávání - "Gwyneth Welch"

Akademický článek

Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics

Autor: Easwaran Ramamurthy, Gwyneth Welch, Jemmie Cheng, Yixin Yuan, Laura Gunsalus, David A. Bennett, Li-Huei Tsai, Andreas R. Pfenning

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2023)

We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and without Alzheimer’s Disease (AD). We confirm that single nucleotide polymo

Externí odkaz: https://doaj.org/article/ceb332e45eeb48778b5b9d9ca1cfaaef

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Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease

Autor: Li-Huei Tsai, Gwyneth Welch

Publikováno v: EMBO reports. 23

Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f92f4d9fc2d816e7852193ffd231420
https://doi.org/10.15252/embr.202154217

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Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Autor: Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsai

SummaryApolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing late- onset Alzheimer’s disease and its expression in microglia is associated with pro- inflammatory states. How the interaction of APOE4 microglia with neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e65379af953ea122df84bcbf9fcdeb2
https://doi.org/10.1101/2022.03.21.484146

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Neurons burdened by DNA double strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

Autor: Gwyneth Welch, Carles Boix, Eloi Schmauch, Jose Davila-Velderrain, Matheus B. Victor, Vishnu Dileep, Lorenzo Bozzelli, Qiao Su, Jemmie Cheng, Audrey Lee, Noelle Leary, Andreas Pfenning, Manolis Kellis, Li-Huei Tsai

DNA double strand breaks (DSBs) are linked to aging, neurodegeneration, and senescence1,2. However, the role played by neurons burdened with DSBs in disease-associated neuroinflammation is not well understood. Here, we isolate neurons harboring DSBs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f75198fd9deae4fd1c2934c9a6fef54
https://doi.org/10.1101/2021.12.23.474002

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