Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Gwyn T, Williams"'
Autor:
Mirna M Maarabouni, Gwyn T Williams
Publikováno v:
The Scientific World Journal, Vol 6, Pp 1705-1712 (2006)
The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis
Externí odkaz:
https://doaj.org/article/96aff7f77cec4b0bb0bdeaa2d099295c
Autor:
Claire L. Anderson, Gwyn T. Williams
Publikováno v:
The Scientific World Journal, Vol 3, Pp 51-58 (2003)
Over the past 10-15 years there has been an explosion of interest in apoptosis. The delayed realisation that cell death is an essential part of life for any multicellular organism has meant that, despite the recent and rapid developments of the last
Externí odkaz:
https://doaj.org/article/04a6ae9f72074334b788d6b9edda9720
Publikováno v:
The Scientific World Journal, Vol 2, Pp 1885-1890 (2002)
The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fac
Externí odkaz:
https://doaj.org/article/552d6a1bef724d2fb4ce6579b3af3927
Autor:
G. Bagetta, Gwyn T. Williams, E. A. Higgs, Noel G. Morgan, Roger D. Hurst, S. Moncada, Anne C. Loweth, G. Nisticò, John H. B. Scarpello
Publikováno v:
Nitric Oxide and the Cell: Proliferation, Differentiation, and Death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca27cb3a50dcab80c978e4fa17df7d2
https://doi.org/10.1515/9781400887538-016
https://doi.org/10.1515/9781400887538-016
Autor:
Mark R. Pickard, Gwyn T. Williams
Publikováno v:
Genes
Genes, Vol 6, Iss 3, Pp 484-499 (2015)
Genes, Vol 6, Iss 3, Pp 484-499 (2015)
It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biolog
Autor:
Mark R. Pickard, Gwyn T. Williams
Publikováno v:
Translational Cancer Research. 5:S564-S566
The investigation of long non-protein-coding RNAs (lncRNAs) has become a key area in biological and biomedical research. This is the result of sequencing and analysis of the human genome, which showed that only around 2% encodes proteins, together wi
Autor:
Gwyn T. Williams, Joop Gaken, Nicola J. McCarthy, Kiren Yacqub-Usman, David Darling, Farzin Farzaneh, Mark R. Pickard, Shu Uin Gan, Aytug Kizilors, Cathleen E Schulte
Publikováno v:
Bioscience Reports
Kizilors, A, Pickard, M R, Schulte, C E, Yacqub-Usman, K, McCarthy, N J, Gan, S-U, Darling, D, Gäken, J, Williams, G T & Farzaneh, F 2017, ' Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival ', Bioscience Reports, vol. 37, no. 4, BSR20170843 . https://doi.org/10.1042/BSR20170843
Kizilors, A, Pickard, M R, Schulte, C E, Yacqub-Usman, K, McCarthy, N J, Gan, S-U, Darling, D, Gäken, J, Williams, G T & Farzaneh, F 2017, ' Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival ', Bioscience Reports, vol. 37, no. 4, BSR20170843 . https://doi.org/10.1042/BSR20170843
The E3 ubiquitin ligase RNF168 is a ring finger protein that has been previously identified to play an important regulatory role in the repair of double-strand DNA breaks. In the present study, an unbiased forward genetics functional screen in mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82b90c9ce0e3ff4d0fdd9459b2529be
https://eprints.keele.ac.uk/4119/1/BSR20170843.full.pdf
https://eprints.keele.ac.uk/4119/1/BSR20170843.full.pdf
Autor:
Mark R. Pickard, Gwyn T. Williams
Publikováno v:
Breast Cancer Research and Treatment. 145:359-370
The putative tumour suppressor and apoptosis-promoting gene, growth arrest-specific 5 (GAS5), encodes long ncRNA (lncRNA) and snoRNAs. Its expression is down-regulated in breast cancer, which adversely impacts patient prognosis. In this preclinical s
Regulation of T-Cell Apoptosis by Sequences Encoded at the Luca-15 Candidate Tumour Suppressor Locus
Autor:
Mirna Mourtada-Maarabouni, Leslie C. Sutherland, Jeremy P. Clark, Colin S. Cooper, Gwyn T. Williams
Publikováno v:
The Scientific World Journal, Vol 1, Pp 38-38 (2001)
Externí odkaz:
https://doaj.org/article/78f3448339ed4f76966e3631407066a3