Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gwydion Churchill"'
Autor:
Helen Benson, Julie Reid, Steven A. Raw, Karen Bones, Andrew Stark, Alan Steven, Sophie Janbon, Gwydion Churchill, J. Gair Ford, Fiona Millington, Lyn Powell, Lianne Frodsham
Publikováno v:
Organic Process Research & Development. 24:588-598
Early chemical development studies into the best way of assembling AZD9742, an antibacterial drug candidate, have involved swapping the order of two reductive aminations. The orthogonally functiona...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d753201f4b0bbe714de5df25ad811439
https://doi.org/10.1021/acs.oprd.0c00029
https://doi.org/10.1021/acs.oprd.0c00029
The authors thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement No. 279850 (J.E.T. and A.T.D.) as well as the EPSRC, UK and AstraZeneca plc, UK (Case award to J.J.D.) for fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f1d8d95fd9a900b01fffb248ed2deb
https://hdl.handle.net/10023/12542
https://hdl.handle.net/10023/12542
Autor:
Moustafa F. Aly, Ronald Grigg, Gwydion Churchill, Hussien H. Abbas‐Temirek, Elghareeb E. Elboray
Publikováno v:
Tetrahedron. 70:110-122
We report protecting group free Pd(0) catalyzed cascade syntheses of molecular scaffolds built from heterocyclic bisallenes. These generate novel molecular architecture permitting tri-directional exploration of biochemical space.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa7753475ed5b0a3969a3fe3be49c92
https://doi.org/10.1016/j.tet.2013.10.060
https://doi.org/10.1016/j.tet.2013.10.060
Autor:
Gwydion Churchill, Charlene Fallan, Christopher J. Collett, James Douglas, Louis C. Morrill, Alyn Davies, Alexandra M. Z. Slawin, Andrew D. Smith, James E. Taylor
Publikováno v:
The Journal of Organic Chemistry. 78:9243-9257
N-Heterocyclic carbene (NHC)-catalyzed redox asymmetric hetero-Diels–Alder reactions of α-aroyloxyaldehydes with β-trifluoromethyl enones generates synthetically useful dihydropyranones containing a stereogenic trifluoromethyl substituent in good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2812c135b3828cc39acc6a54ad37861d
https://doi.org/10.1021/jo401433q
https://doi.org/10.1021/jo401433q
Publikováno v:
ChemInform. 47
Stereo- and chemodivergent enantioselective reaction pathways are observed upon treatment of alkylarylketenes and trichloroacetaldehyde (chloral) with N-heterocyclic carbenes, giving selectively either β-lactones or α-chloro esters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19fb7a5e9245d51a879a89bf56c822d3
https://doi.org/10.1002/chin.201616118
https://doi.org/10.1002/chin.201616118
Publikováno v:
Synthesis. 44:2295-2309
Organocatalysis represents a synthetic paradigm that has grown exponentially in popularity over the last decade, arguably becoming one of the most desired synthetic methods for the creation of enantiomerically enriched products. Within this field the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40106a31e5ebdbe993ad2a916b7fa7cb
https://doi.org/10.1055/s-0031-1289788
https://doi.org/10.1055/s-0031-1289788
Autor:
Mark Drew, J. Gair Ford, Alistair Boyd, Kevin William Leslie, Ji-long Jiang, Bob Suchozak, Stephen Gottschling, Gwydion Churchill, Sarah Lyons, Paula Tomlin, Josephine Lo, Murray Watson AstraZeneca Cuthbert, Matthew Ball, Michael David Golden, Andrew Stark, Lianne Frodsham, Ben McKeever-Abbas, Mark Richard Fielding, Abraham Hajar
Publikováno v:
Organic Process Research & Development. 16:741-747
The intramolecular Diels–Alder reaction provides a useful synthetic methodology to build biologically active and synthetically useful isoindolone ring systems. An application of this methodology, p...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c528a5c1ed16c94382062fccf77b5bac
https://doi.org/10.1021/op300002f
https://doi.org/10.1021/op300002f
Publikováno v:
Tetrahedron Letters. 52:3657-3661
An improved methodology for the synthesis of substituted pyrido[2,3-d]pyrimidinediones from 6-aminouracils and the corresponding enaminone has been developed which provides high yields via an operationally simple process. The method has been extended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5690a0e75044aba5c64664e094def7fb
https://doi.org/10.1016/j.tetlet.2011.05.021
https://doi.org/10.1016/j.tetlet.2011.05.021
Autor:
Kenneth B. Ling, Gwydion Churchill, Alexandra M. Z. Slawin, Carmen Concellon, Andrew D. Smith, James Douglas
Publikováno v:
European Journal of Organic Chemistry. 2010:5863-5869
NHCs promote the efficient chlorination of unsymmetrical disubstituted ketenes with a range of chlorinating agents; chiral NHCs display promising levels of asymmetric induction in the chlorination process with up to 61 % ee observed using 2,3,4,5,6,6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c85df00474fa52b56646873352e6801
https://doi.org/10.1002/ejoc.201000864
https://doi.org/10.1002/ejoc.201000864
Autor:
Thomas B. Brown, Nicolas Duguet, James Douglas, Gwydion Churchill, Alexandra M. Z. Slawin, Peter Shapland, Adele Donaldson, Stuart M. Leckie, Andrew D. Smith
Publikováno v:
Tetrahedron: Asymmetry. 21:582-600
The synthesis of a range of C 2 -symmetric imidazolinium salts from (1 R ,2 R )-cyclohexane-1,2-diamine, and an evaluation of the reactivity and asymmetric induction of the derived NHCs as catalysts for the asymmetric synthesis of β-lactams, is repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1840b2b699d377a41e374e6f8b38780
https://doi.org/10.1016/j.tetasy.2010.03.001
https://doi.org/10.1016/j.tetasy.2010.03.001