Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Gwong-Cheung Hur"'
1
Design and Synthesis of Oxime Ethers of β-Oxo-γ-phenylbutanoic Acids as PPAR α and -γ Dual Agonists
Autor: Seung H. Kim, Hyeon Joo Yim, Jong Sung Koh, Kyoung-Hee Kim, Ok Ku Park, Geun Tae Kim, Gwong-Cheung Hur, Hee Oon Han, Sang Kweon Jeon
Publikováno v: Bulletin of the Korean Chemical Society. 33:1979-1982
of 2.5 nM and 3.3 nM inPPAR α and γ, respectively. It showed better glucose lowering effects than rosiglitazone 1 and improved thelipid profile like plasma triglyceride in db/db mice model.Key Words : PPAR α and γ dual agonist, Diabetes, Oxime et
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff893606ed15bc994fb0e1752de0de94
https://doi.org/10.5012/bkcs.2012.33.6.1979
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2
Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: Oxadiazolyl ketones
Autor: Chang Seok Lee, Geun Tae Kim, Min-Jung Kim, Sang Yong Hong, Hee Oon Han, Gwong-Cheung Hur, O Hwan Kwon, Kyoung-Hee Kim, Sungsub Kim, Jong Sung Koh, Ki Dong Koo, Hyeon Joo Yim, Tae Sik Kwon
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:4167-4172
Synthesis of a novel series of DPPIV inhibitors with 1,2,4- and 1,3,4-oxadiazolyl ketone derivatives and its structure–activity relationships are discussed. Compound 18h showed good inhibitory activity against DPPIV and favorable pharmacokinetic pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9292fe70f399944b3adad2316c5fd0
https://doi.org/10.1016/j.bmcl.2007.05.046
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3
Upregulation of FLIPS by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers
Autor: Dai Wu Seol, Seon Young Nam, Hee Yong Chung, Gwong Cheung Hur, Woo Ho Kim, Gyung Ah Jung, Byung Lan Lee
Publikováno v: Cancer Science. 94:1066-1073
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in some, but not all cancer cells. To assess the regulation of TRAIL-resistance in the human gastric cancer cells, we examined TRAIL sensitivity, TRAIL r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e5cc048848d18ec24ae267cb3b3d69
https://doi.org/10.1111/j.1349-7006.2003.tb01402.x
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4
Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists
Autor: Hee-Kyung Chung, Kyoung-Hee Kim, Seung H. Kim, Hee Oon Han, Jong Sung Koh, Sung Ho Woo, Hyeon Joo Yim, Chang Seok Lee, Ki Dong Koo, Geun Tae Kim, Gwong-Cheung Hur
Publikováno v: Bioorganicmedicinal chemistry letters. 17(4)
Oxime ethers of alpha-acyl-beta-phenylpropanoic acids were prepared to apply as PPARalpha and gamma dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC(50) of 19 and 13nM in PPARalpha and gamma, respectively.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff6d1356a62dd8372bcc98a6796a737
https://pubmed.ncbi.nlm.nih.gov/17157019
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5
Manganese superoxide dismutase expression correlates with chemosensitivity in human gastric cancer cell lines
Autor: Gwong-Cheung, Hur, Sung Jin, Cho, Chan-Hyung, Kim, Min Kyu, Kim, Soo In, Bae, Seon Young, Nam, Jong-Wan, Park, Woo Ho, Kim, Byung Lan, Lee
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(15)
The purpose is to investigate the potential correlation between antioxidant enzyme (AOE) levels and resistance to anticancer drugs in human gastric carcinoma cell lines.Protein contents of AOEs such as manganese superoxide dismutase (MnSOD), copper/z
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c266659a4563f3a8869c04e9f505302b
https://pubmed.ncbi.nlm.nih.gov/14654562
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6
Manganese superoxide dismutase expression correlates with a poor prognosis in gastric cancer
Autor: Byung Lan Lee, Jimi Choi, Seoung Wan Chae, Gwong Cheung Hur, Sung Jin Cho, Han-Kwang Yang, Min Kyu Kim, Jeong Jin Kim, Seon Young Nam, Woo Ho Kim
Publikováno v: Pathobiology : journal of immunopathology, molecular and cellular biology. 70(6)
Objective: The biologic significance of superoxide dismutase (SOD) in transformed gastric carcinoma cells is unclear. The aim of this study was to examine the role of SOD as a prognostic indicator of gastric carcinomas and its association with other
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fc7d8698f777123498bdf2a0ab13bb
https://pubmed.ncbi.nlm.nih.gov/12865632
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