Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Gwo-tzer Ho"'
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 10 (2024)
Externí odkaz:
https://doaj.org/article/0916f250aec14dcbaceea4972f7c6c4f
Autor:
Han Zhang, Rahul Kalla, Jie Chen, Jianhui Zhao, Xuan Zhou, Alex Adams, Alexandra Noble, Nicholas T. Ventham, Judith Wellens, Gwo-Tzer Ho, Malcolm G. Dunlop, Jan Krzysztof Nowak, Yuan Ding, Zhanju Liu, Jack Satsangi, Evropi Theodoratou, Xue Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking be
Externí odkaz:
https://doaj.org/article/04a74e10927f428d84730e560996c873
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 6, Pp 788-798 (2023)
Background and Aims: Inflammatory bowel disease (IBD) is associated with increased circulating damage-associated molecular patterns, in particular, the highly pro-inflammatory mitochondrial DNA (mtDNA). Here, we study the importance of blood neutroph
Externí odkaz:
https://doaj.org/article/54c3abbc21154a52a47b0378933a9b8c
Autor:
Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex T. Adams, Alexandra Noble, Holly Ennis, Craig Mowat, Malcolm G. Dunlop, Jack Satsangi, Ian Arnott, Aiden Cahill, Malcolm Smith, Tariq Ahmad, Sreedhar Subramanian, Simon Travis, John Morris, John Hamlin, Anjan Dhar, Chuka Nwokolo, Cathryn Edwards, Tom Creed, Stuart Bloom, Mohamed Yousif, Linzi Thomas, Simon Campbell, Stephen J. Lewis, Shaji Sebastian, Sandip Sen, Simon Lal, Chris Hawkey, Charles Murray, Fraser Cummings, Jason Goh, James O. Lindsay, Naila Arebi, Lindsay Potts, Aileen J. McKinley, John M. Thomson, John A. Todd, Mhairi Collie, Ashley Mowat, Daniel R. Gaya, Jack Winter, Graham D. Naismith, Catriona Keerie, Steff Lewis, Robin J. Prescott, Gordan Lauc, Harry Campbell, Dermot P.B. McGovern, Vito Annese, Vlatka Zoldoš, Iain K. Permberton, Manfred Wuhrer, Daniel Kolarich, Daryl L. Fernandes, Evropi Theorodorou, Victoria Merrick Daniel I. Spencer, Richard A. Gardner, Ray Doran, Archana Shubhakar, Ray Boyapati, Igor Rudan, Paolo Lionetti, Irena Trbojević Akmačić, Jasminka Krištić, Frano Vuč ković, Jerko Štambuk, Mislav Novokmet, Maja Pučić-Baković, Olga Gornik, Angelo Andriulli, Laura Cantoro, Giancarlo Sturniolo, Gionata Fiorino, Natalia Manetti, Anna Latiano, Anna Kohn, Renata D’Inca`, Silvio Danese, Ian D. Arnott, Colin L. Noble, Charlie W. Lees, Alan G. Shand, Gwo-Tzer Ho, Lee Murphy, Jude Gibson, Louise Evenden, Nicola Wrobel, Tamara Gilchrist, Angie Fawkes, Guinevere S.M. Kammeijer, Florent Clerc, Noortje de Haan, Aleksandar Vojta, Ivana Samaržija, Dora Markulin, Marija Klasić, Paula Dobrinić, Yurii Aulchenko, Tim van den Heuve, Daisy Jonkers, Marieke Pierik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 431-450 (2023)
Background & Aims: DNA methylation alterations may provide important insights into gene-environment interaction in cancer, aging, and complex diseases, such as inflammatory bowel disease (IBD). We aim first to determine whether the circulating DNA me
Externí odkaz:
https://doaj.org/article/f32b67ecfa854c6487a3c5196a5070e3
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 321-333 (2021)
The Inflammatory Bowel Diseases (IBD), Ulcerative Colitis (UC) and Crohn’s Disease (CD) are characterised by chronic non-resolving gut mucosal inflammation involving innate and adaptive immune responses. Neutrophils, usually regarded as first respo
Externí odkaz:
https://doaj.org/article/cf6c37c2f513471baa0952d50de1fc84
Publikováno v:
F1000Research, Vol 6 (2017)
Mitochondrial DNA (mtDNA) has many similarities with bacterial DNA because of their shared common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger signal that is recognised by the innate immune system and can directly modulate t
Externí odkaz:
https://doaj.org/article/0d3f5a44bd474ea1aa4d6bb96eaaa719
Autor:
Charlie W Lees, William J Zacharias, Mark Tremelling, Colin L Noble, Elaine R Nimmo, Albert Tenesa, Jennine Cornelius, Leif Torkvist, John Kao, Susan Farrington, Hazel E Drummond, Gwo-Tzer Ho, Ian D R Arnott, Henry D Appelman, Lauri Diehl, Harry Campbell, Malcolm G Dunlop, Miles Parkes, Sarah E M Howie, Deborah L Gumucio, Jack Satsangi
Publikováno v:
PLoS Medicine, Vol 5, Iss 12, p e239 (2008)
BackgroundUlcerative colitis (UC) and Crohn's disease (CD) are polygenic chronic inflammatory bowel diseases (IBD) of high prevalence that are associated with considerable morbidity. The hedgehog (HH) signalling pathway, which includes the transcript
Externí odkaz:
https://doaj.org/article/dc132a3d122a4fa89cfe6f334c40a2ec
Autor:
Duncan Rutherford, Gwo-Tzer Ho
Publikováno v:
Inflammatory Bowel Diseases.
Inflammatory bowel diseases (IBDs) are chronic immune-mediated conditions characterized by significant gut tissue damage due to uncontrolled inflammation. Anti-inflammatory treatments have improved, but there are no current prorepair approaches. Orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d547692185d2eb2fe2426b53625a2502
https://doi.org/10.1093/ibd/izad044
https://doi.org/10.1093/ibd/izad044
Autor:
Yuhao Sun, Shuai Yuan, Xuejie Chen, Jing Sun, Rahul Kalla, Lili Yu, Lijuan Wang, Xuan Zhou, Xiangxing Kong, Therese Hesketh, Gwo-tzer Ho, Kefeng Ding, Malcolm Dunlop, Susanna C. Larsson, Jack Satsangi, Jie Chen, Xiaoyan Wang, Xue Li, Evropi Theodoratou, Edward L Giovannucci
Publikováno v:
Sun, Y, Yuan, S, Chen, X, Sun, J, Kalla, R, Yu, L, Wang, L, Zhou, X, Kong, X, Hesketh, T, Ho, G-T, Ding, K, Dunlop, M G, Larsson, S C, Satsangi, J, Chen, J, Wang, X, Li, X, Theodoratou, E & Giovannucci, E L 2023, ' The contribution of genetic risk and lifestyle factors in the development of adult-onset inflammatory bowel disease : a prospective cohort study ', The American Journal of Gastroenterology, vol. 118, no. 3, pp. 511-522 . https://doi.org/10.14309/ajg.0000000000002180
SummaryObjectiveThere are few prospective data exploring the combined effect of genetic and lifestyle factors on the incidence of inflammatory bowel disease (IBD), and whether genetic risk of IBD may be mitigated by lifestyle remains unclear.DesignWe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89327c84039adfbb5e0337640fccd465
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-507039
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-507039
The MUSIC study is a multi-centre, longitudinal study set in the real world IBD clinical setting to investigate and develop a new biomarker approach utilising mitochondrial DAMP and circulating DNA in assessing mucosal healing in Crohn’s disease. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dab2f16ad7b372fa1c7b2d344c29a0b
https://doi.org/10.1101/2022.03.21.22270313
https://doi.org/10.1101/2022.03.21.22270313