Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Gwo Jyh Chang"'
Autor:
Martina Arici, Shih-Che Hsu, Mara Ferrandi, Paolo Barassi, Carlotta Ronchi, Eleonora Torre, Andrea Luraghi, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Francesco Peri, Antonio Zaza, Marcella Rocchetti
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that SERCA2a stimulation may be a mechanism-based HF therapy. Istaroxime is a dr
Externí odkaz:
https://doaj.org/article/782d6a7de41e442dbf9d2b9799220397
Autor:
Yi-Hsin Chan, Feng-Chun Tsai, Gwo-Jyh Chang, Ying-Ju Lai, Shang-Hung Chang, Wei-Jan Chen, Yung-Hsin Yeh
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-19 (2023)
Abstract Background Sustained, chronic activation of β-adrenergic receptor (β-AR) signaling leads to cardiac arrhythmias, with exchange proteins directly activated by cAMP (Epac1 and Epac2) as key mediators. This study aimed to evaluate whether CD4
Externí odkaz:
https://doaj.org/article/701aa8fd9c4549ef889d3e6014e9bacd
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2186 (2024)
Atrial fibrillation (AF), characterized by structural remodeling involving atrial myocardial degradation and fibrosis, is linked with obesity and transforming growth factor beta 1 (TGF-β1). Aldehyde dehydrogenase 2 (ALDH2) deficiency, highly prevale
Externí odkaz:
https://doaj.org/article/6cdd6a3e50874de390dbf517f3d5a7bb
Autor:
Yu-Wen Cheng, Chia-Tung Wu, Chi-Jen Chang, Yung-Hsin Yeh, Gwo-Jyh Chang, Hsin-Yi Tsai, Lung-An Hsu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12742 (2023)
KCNH2 loss-of-function mutations cause long QT syndrome type 2 (LQT2), an inherited cardiac disorder associated with life-threatening ventricular arrhythmia. Through whole-exome sequencing, we discovered a novel AGCGACAC deletion (S981fs) in the hERG
Externí odkaz:
https://doaj.org/article/03c77d282e8749e49c9b61a55e000705
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 15 (2022)
Background Cardiac hypertrophy is associated with abnormal electrophysiology and increased arrhythmia risk. This study assessed whether candesartan cilexetil, an angiotensin II type 1 receptor blocker, could suppress arrhythmogenecity by attenuating
Externí odkaz:
https://doaj.org/article/3513e34a57bb474885b91dcb8b4d423e
Autor:
Ying-Ju Lai, Feng-Chun Tsai, Gwo-Jyh Chang, Shang-Hung Chang, Chung-Chi Huang, Wei-Jan Chen, Yung-Hsin Yeh
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Atrial fibrosis is an essential contributor to atrial fibrillation (AF). It remains unclear whether atrial endocardial endothelial cells (AEECs) that undergo endothelial-mesenchymal transition (EndMT) are among the sources of atrial fibroblasts. We s
Externí odkaz:
https://doaj.org/article/b7502b3db98d45b1bfc9a78042c36c5b
Autor:
Yi-Hsin Chan, Gwo-Jyh Chang, Ying-Ju Lai, Wei-Jan Chen, Shang-Hung Chang, Li-Man Hung, Chi-Tai Kuo, Yung-Hsin Yeh
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-14 (2019)
Abstract Background Insulin resistance (IR) is considered as a risk factor for atrial fibrillation (AF) even before diabetes develops. The pathophysiology and underlying mechanism are largely unclear. Methods We investigated the corresponding mechani
Externí odkaz:
https://doaj.org/article/d307551a71664362856544127d40bc2d
Autor:
Ying-Chang Tung, Mei-Ling Cheng, Lung-Sheng Wu, Hsiang-Yu Tang, Cheng-Yu Huang, Gwo-Jyh Chang, Chi-Jen Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6809 (2022)
Derangements in cardiac energy metabolism have been shown to contribute to the development of heart failure (HF). This study combined transcriptomics and metabolomics analyses to characterize the changes and reversibility of cardiac energetics in a r
Externí odkaz:
https://doaj.org/article/d2a95e4fcb3343c5974196b7a5f38734
Autor:
Chi-Jen Chang, Ying-Ju Lai, Ying-Chang Tung, Lung-Sheng Wu, Lung-An Hsu, Chi-Nan Tseng, Gwo-Jyh Chang, Kai-Chien Yang, Yung-Hsin Yeh
Publikováno v:
Kidney International. 103:702-718
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d386383a363a1734ca088279ed91fe
https://doi.org/10.1016/j.kint.2022.12.022
https://doi.org/10.1016/j.kint.2022.12.022
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0234591 (2021)
Paraquat (PQ) is a highly lethal herbicide. Ingestion of large quantities of PQ usually results in cardiovascular collapse and eventual mortality. Recent pieces of evidence indicate possible involvement of oxidative stress- and inflammation-related f
Externí odkaz:
https://doaj.org/article/96e45f18685f49e3a6f32fd761bbbf26