Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Gwladys Langot"'
Autor:
Philippe Péron, Marie-Aude Chabanaud, Gwladys Langot, Etienne Guillot, Florence Goumy, Patrick Mougenot, Cecile Pascal, Olivier Crespin, Fabrice Viviani, Majdi Ben-Hassine, Friedemann Schmidt, Eykmar Fett, Jean-Christophe Le Bail, Jean-Luc Ragot, Bénédicte Onofri, Rommel Dadji-Faïhun, Christophe Philippo, Thao Van-Pham, Catherine Monseau, Olivier Venier, Jerome Menegotto, Florence Chatelain-Egger, Marie-Pierre Pruniaux, François Pacquet, Philippe Chamiot-Clerc, Eric Nicolai, Claudie Namane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:25-32
Chemical modulation of a formerly disclosed DGAT-1 inhibitor resulted in the identification of a compound with a suitable profile for preclinical development. Optimisation of solubility is discussed and a PK/PD study is presented.
Autor:
Friedemann Schmidt, Philippe Péron, Jean-Luc Ragot, Thao Van-Pham, Marie-Aude Chabanaud, Jean-Christophe Le Bail, Olivier Venier, Eric Nicolai, Claudie Namane, Bénédicte Onofri, Majdi Ben-Hassine, Patrick Mougenot, Rommel Dadji-Faïhun, François Pacquet, Philippe Chamiot-Clerc, Cecile Pascal, Catherine Monseau, Etienne Guillot, Christophe Philippo, Florence Camy, Olivier Crespin, Florence Chatelain-Egger, Marie-Pierre Pruniaux, Fabrice Viviani, Gwladys Langot, Eykmar Fett
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(7)
A novel class of DGAT1 inhibitors containing a thiadiazole core has been discovered. Chemical optimization lead to inhibitors of human DGAT1 with an appropriate ADME profile and that show in vivo activity in target tissues.