Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells

Autor: Nina Guyon, Delphine Garnier, Joséphine Briand, Arulraj Nadaradjane, Gwenola Bougras-Cartron, Judith Raimbourg, Mario Campone, Dominique Heymann, François M. Vallette, Jean-Sébastien Frenel, Pierre-François Cartron

Publikováno v: Cell Death and Disease, Vol 11, Iss 12, Pp 1-11 (2020)

Abstract Anti-PD1 immunotherapy, as a single agent or in combination with standard chemotherapies, has significantly improved the outcome of many patients with cancers. However, resistance to anti-PD1 antibodies often decreases the long-term therapeu

Externí odkaz: https://doaj.org/article/a9df5a188ee4453c9e09d42ff5c0c69d

miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker

Autor: Arulraj Nadaradjane, Joséphine Briand, Gwenola Bougras-Cartron, Valentine Disdero, François M. Vallette, Jean-Sébastien Frenel, Pierre-François Cartron

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 642-650 (2018)

In the last decade, microRNAs (miRs) have been described as biomarkers and therapeutic agents. Based on this finding, our aim here is to know if (1) miRNA-370-3p can be used as a biomarker associated with a favorable survival and if (2) miRNA-370-3p

Externí odkaz: https://doaj.org/article/7362bc54b37f4aadb1a5de236436990f

Adenosine Methylation Level of miR-125a-5p Promotes Anti-PD-1 Therapy Escape through the Regulation of IGSF11/VSIG3 Expression

Autor: Cartron, Gwenola Bougras-Cartron, Arulraj Nadaradjane, Marie-Pierre Joalland, Lisenn Lalier-Bretaudeau, Judith Raimbourg, Pierre-François

Publikováno v: Cancers; Volume 15; Issue 12; Pages: 3188

Background: Despite encouraging anti-tumour activity in lung cancer, anti-PD-1 therapy has encountered increasing resistance to treatment. Several companion diagnostic assays have been performed to identify patients who may benefit from this immunoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::f491ad2b2e19c3acfff6bfc42e1a0c4b

Modulation of DNA Methylation/Demethylation Reactions Induced by Nutraceuticals and Pollutants of Exposome Can Promote a Cgt; T Mutation in the Breast Cancer Predisposing Gene

Autor: Florestan, Courant, Gwenola, Bougras-Cartron, Caroline, Abadie, Jean-Sébastien, Frenel, Pierre-François, Cartron

Publikováno v: Epigenomes. 6(4)

Deregulation of DNA methylation/demethylation reactions may be the source of Cgt; T mutation via active deamination of 5-methylcytosine to thymine. Exposome, that is to say, the totality of exposures to which an individual is subjected during their l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d7de7eba511c95b60cf236eec137e37
https://pubmed.ncbi.nlm.nih.gov/36278678

N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool

Autor: Arulraj Nadaradjane, Joséphine Briand, Aurélien A. Sérandour, Gwenola Bougras-Cartron, Dominique Heymann, Benjamin Ory, Pierre-François Cartron, François M. Vallette

Publikováno v: Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, 2020, 22, pp.72-83. ⟨10.1016/j.omtn.2020.08.010⟩
Molecular Therapy-Nucleic Acids, Elsevier, 2020, 22, pp.72-83. ⟨10.1016/j.omtn.2020.08.010⟩
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 72-83 (2020)
Molecular Therapy. Nucleic Acids

MicroRNAs (miRNAs or miRs) play crucial roles in biological and pathological processes. Some miRNAs also appear as promising biomarkers and therapeutic tools. However, the epitranscriptomic regulation of miRNAs is not yet fully elucidated in all of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbad578718818d577caec3646ed097f
https://hal.science/hal-03004313/document