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Autor:
Gwenola Auffret, Guy Lewin, François Frappier, Philippe Rasoanaivo, Philippe Grellier, Mehdi Labaied
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (4), pp.959-963. ⟨10.1016/j.bmcl.2006.11.051⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (4), pp.959-963. ⟨10.1016/j.bmcl.2006.11.051⟩
A series of 27 flavonoid derivatives containing a piperazinyl chain have been synthesized and tested for their antiplasmodial activity. Diverse substitution patterns on piperazinyl and flavone moieties were examined and found to affect the activity d