Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Gwenn M. Hansen"'
Autor:
Ernestine Lee, Alexandra Borodovsky, Marilena Gallotta, Jose Gomez Romo, Serena Ranucci, Gwenn M Hansen, Arthur T Sands, Ryan Rountree, Cristiana Guiducci
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/388368403fa8435f8ad6c1061e1efde2
Publikováno v:
Veterinary Pathology. 58:1158-1171
The development of mouse models that replicate the genetic and pathological features of human disease is important in preclinical research because these types of models enable the completion of meaningful pharmacokinetic, safety, and efficacy studies
Autor:
Christopher M. DaCosta, Robert Brommage, Isaac Van Sligtenhorst, Zhi-Ming Ding, Gwenn M. Hansen, Kenneth A. Platt, Jean-Pierre Revelli, Deon Doree, David R. Powell
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:2641-2652
Purpose In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links
Autor:
David R Powell, Jason P Gay, Nathaniel eWilganowski, Deon eDoree, Katerina V Savelieva, Thomas H Lanthorn, Robert eRead, Peter eVogel, Gwenn M Hansen, Robert eBrommage, Zhi-Ming eDing, Urvi eDesai, Brian eZambrowicz
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
After creating >4650 knockouts (KOs) of independent mouse genes, we screened them by high-throughput phenotyping and found that cannabinoid receptor 1 (Cnr1) KO mice had the same lean phenotype published by others. We asked if our KOs of DAG lipase a
Externí odkaz:
https://doaj.org/article/2cd8cddb02a7428f8fc63bddb47507e2
Autor:
Qingyun Liu, Sabrina Jeter-Jones, Dawn Bright, Sofia Movérare-Skrtic, Peter Vogel, Jeff Liu, David Potter, Arthur T. Sands, Faika Mseeh, Petra Henning, Ulf H. Lerner, Robert Brommage, David R. Powell, Karin H Nilsson, James E. Tarver, Claes Ohlsson, Andrea Y. Thompson, Gwenn M. Hansen, Jennifer Bardenhagen, Brian Zambrowicz, Melanie K. Shadoan, Jie Cui, Deon Doree
Publikováno v:
Bone Research, Vol 7, Iss 1, Pp 1-12 (2019)
Bone Research
Bone Research
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major determinant of non-v
Autor:
Marilena Gallotta, Jose Gomez Romo, Alexandra Borodovsky, Austin Tenn-McClellan, Jennifer Stokes, Jennifa Gosling, Gwenn M. Hansen, Arthur Sands, Ryan Rountree, Cristiana Guiducci
Publikováno v:
Cancer Research. 82:573-573
Adoptive cell transfer (ACT) involving autologous tumor-specific lymphocytes (TIL) has shown promising results in the treatment of advanced cancer. Poor in vitro cell expansion, inefficient T-cell migration and T cell exhaustion in the tumor microenv
Autor:
Christopher M. DaCosta, Melissa Hansard, R. Read, David R. Powell, Daniel L. Small, Zhi-Ming Ding, Peter Vogel, Gwenn M. Hansen, Robert Brommage, Gui-Lan Ye
Publikováno v:
Veterinary pathology. 57(5)
Mice with an inactivating mutation in the gene encoding asparagine synthetase domain containing 1 (ASNSD1) develop a progressive degenerative myopathy that results in severe sarcopenia and myosteatosis. ASNSD1 is conserved across many species, and wh
Autor:
David R, Powell, Deon D, Doree, Christopher M, DaCosta, Kenneth A, Platt, Gwenn M, Hansen, Isaac, van Sligtenhorst, Zhi-Ming, Ding, Jean-Pierre, Revelli, Robert, Brommage
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Purpose In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links
Autor:
Dennis S Rice, Gwenn M Hansen, Feng Liu, Mike J Crist, Matthew M Newhouse, David Potter, Nianhua Xu, Alejandro Abuin, Peter J Vogel, Brian P Zambrowicz
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47168 (2012)
In vitro studies have identified LIMK2 as a key downstream effector of Rho GTPase-induced changes in cytoskeletal organization. LIMK2 is phosphorylated and activated by Rho associated coiled-coil kinases (ROCKs) in response to a variety of growth fac
Externí odkaz:
https://doaj.org/article/d0b6dd9ad1ed4edaa083cdbe2c1dc8bf
Autor:
Daniel W. Robbins, Nivetha Brathaban, Dane E. Karr, Austin Tenn-McClellan, Arthur T. Sands, Jun Ma, May Tan, Gwenn M. Hansen, Timothy Ingallinera, Jenny McKinnell, Cristiana Guiducci, Ryan Rountree, Aileen Kelly, Zef Konst, Luz Perez, Mark Noviski
Publikováno v:
Blood. 138:2251-2251
Bruton's tyrosine kinase (BTK) plays a key role in cell survival in B cell malignancies, and covalent inhibitors of BTK, such as ibrutinib and acalabrutinib, have proven efficacious in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), m