Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gwendolyn Vliegen"'
Autor:
Euy Sung Moon, Filipe Elvas, Gwendolyn Vliegen, Stef De Lombaerde, Christel Vangestel, Sven De Bruycker, An Bracke, Elisabeth Eppard, Lukas Greifenstein, Benedikt Klasen, Vasko Kramer, Steven Staelens, Ingrid De Meester, Pieter Van der Veken, Frank Rösch
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-20 (2020)
Abstract Background Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other diseases that are characterized by tissue remodeling. In 2014, a most potent FAP-inhibit
Externí odkaz:
https://doaj.org/article/6eef6de76ec3424eabc82ef799f24e24
Autor:
Gwendolyn Vliegen, Kaat Kehoe, An Bracke, Emilie De Hert, Robert Verkerk, Erik Fransen, Bart 's Jongers, Esther Peters, Anne-Marie Lambeir, Samir Kumar-Singh, Peter Pickkers, Philippe G Jorens, Ingrid De Meester
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231555 (2020)
The proline-specific enzymes dipeptidyl peptidase 4 (DPP4), prolylcarboxypeptidase (PRCP), fibroblast activation protein α (FAP) and prolyl oligopeptidase (PREP) are known for their involvement in the immune system and blood pressure regulation. Onl
Externí odkaz:
https://doaj.org/article/99554ae4708e4af4b6b120c3a9394279
Autor:
Karen Claesen, Yani Sim, An Bracke, Michelle De bruyn, Emilie De Hert, Gwendolyn Vliegen, An Hotterbeekx, Alexandra Vujkovic, Lida van Petersen, Fien H. R. De Winter, Isabel Brosius, Caroline Theunissen, Sabrina van Ierssel, Maartje van Frankenhuijsen, Erika Vlieghe, Koen Vercauteren, Samir Kumar-Singh, Ingrid De Meester, Dirk Hendriks
Publikováno v:
Journal of Clinical Medicine; Volume 11; Issue 6; Pages: 1494
Journal of Clinical Medicine
Journal of Clinical Medicine
Coronavirus disease 2019 (COVID-19) is a viral lower respiratory tract infection caused by the highly transmissible and pathogenic SARS-CoV-2 (severe acute respiratory-syndrome coronavirus-2). Besides respiratory failure, systemic thromboembolic comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322327bfc0fb7319ce0d9f3841ba5128
https://pubmed.ncbi.nlm.nih.gov/35329820
https://pubmed.ncbi.nlm.nih.gov/35329820
Autor:
Siham Benramdane, Joni De Loose, Olivier Beyens, Yentl Van Rymenant, Gwendolyn Vliegen, Koen Augustyns, Hans De Winter, Ingrid De Meester, Pieter Van der Veken
Publikováno v:
ChemMedChem
Vildagliptin is a marketed DPP4 inhibitor, used in the management of type 2 diabetes. The molecule also has notable DPP8/9 affinity, with some preference for DPP9. Therefore, we aimed to use vildagliptin as a starting point for selective DPP8/9 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b25dc7ec8541f1744512a1c6c1d3e2
https://hdl.handle.net/10067/1892990151162165141
https://hdl.handle.net/10067/1892990151162165141
Autor:
An Bracke, Emilie De Hert, Michelle De bruyn, Karen Claesen, Gwendolyn Vliegen, Alexandra Vujkovic, Lida van Petersen, Fien H.R. De Winter, An Hotterbeekx, Isabel Brosius, Caroline Theunissen, Sabrina Van Ierssel, Maartje van Frankenhuijsen, Erika Vlieghe, Koen Vercauteren, Pieter Van der Veken, Dirk Hendriks, Samir Kumar-Singh, Ingrid De Meester
Publikováno v:
Clinica chimica acta
Background: COVID-19 patients experience several features of dysregulated immune system observed in sepsis. We previously showed a dysregulation of several proline-selective peptidases such as dipeptidyl peptidase 4 (DPP4), fibroblast activation prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7818bc1311c45c36609df8222c3a9d7c
https://pubmed.ncbi.nlm.nih.gov/35283094
https://pubmed.ncbi.nlm.nih.gov/35283094
Autor:
Pieter Van der Veken, Gwendolyn Vliegen, Ruth Geiss-Friedlander, Ingrid De Meester, Koen Jansen, An De Decker, Anke Peeraer, Line Verckist, Dries Van Rompaey, Anne-Marie Lambeir, Koen Augustyns, Hans De Winter, An Bracke
Publikováno v:
ACS Med Chem Lett
ACS medicinal chemistry letters
ACS medicinal chemistry letters
[Image: see text] Fibroblast activation protein (FAP) is a proline-selective serine protease. It is hardly expressed in healthy adult tissue but upregulated in tissue remodeling sites associated with several diseases including epithelial cancer types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d228821345597060cdd871eb65c0c776
https://doi.org/10.1021/acsmedchemlett.9b00191
https://doi.org/10.1021/acsmedchemlett.9b00191
Autor:
Steven Staelens, Euy Sung Moon, Meester I De, Benedikt Klasen, Frank Rösch, P. Van der Veken, Lukas Greifenstein, Vasko Kramer, Gwendolyn Vliegen, Anvesh Jallapally, Elisabeth Eppard, Filipe Elvas
Publikováno v:
58. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87e5b9161fd2bf6ea86831dbbbe518a
https://doi.org/10.1055/s-0040-1708137
https://doi.org/10.1055/s-0040-1708137
Publikováno v:
Pharmacology and therapeutics
CD26/dipeptidyl peptidase (DPP)4 is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metastases express CD26/DPP4 to a var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e14e43dc6a32c87391ca0c223bd376c
https://www.zora.uzh.ch/id/eprint/183501/
https://www.zora.uzh.ch/id/eprint/183501/
Autor:
Ingrid De Meester, Anne-Marie Lambeir, Gwendolyn Vliegen, Anvesh Jallapally, Ruth Geiss-Friedlander, Mohamed Lamkanfi, Nina Van Opdenbosch, Pieter Van der Veken, Rosa Martín-Pérez, Emilie De Hert, Amanda Gonçalves, Nathalia Moraes de Vasconcelos, Koen Augustyns
Publikováno v:
LIFE SCIENCE ALLIANCE
Life Science Alliance
Life Science Alliance
This study shows that caspase-1 autocleavage, ASC speck assembly, and mature IL-1β and IL-18 secretion accompany rapid DPP8/DPP9-regulated pyroptosis induction in macrophages expressing a LeTx-responsive Nlrp1b allele.
Activating germline mutat
Activating germline mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a3d744e62583c0ad6d59fba497e54e
https://biblio.ugent.be/publication/8600762/file/8600764
https://biblio.ugent.be/publication/8600762/file/8600764
Autor:
Samir Kumar-Singh, Anne-Marie Lambeir, Philippe G. Jorens, Erik Fransen, Bart ‘s Jongers, Gwendolyn Vliegen, Peter Pickkers, Ingrid De Meester, Kaat Kehoe, Emilie De Hert, Robert Verkerk, Esther Peters, An Bracke
Publikováno v:
PLoS One, 15, 4
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231555 (2020)
PLoS One, 15
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231555 (2020)
PLoS One, 15
The proline-specific enzymes dipeptidyl peptidase 4 (DPP4), prolylcarboxypeptidase (PRCP), fibroblast activation protein α (FAP) and prolyl oligopeptidase (PREP) are known for their involvement in the immune system and blood pressure regulation. Onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977251362e01ed2984cd0aa729d43937
https://doi.org/10.1371/journal.pone.0231555
https://doi.org/10.1371/journal.pone.0231555