Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gwendolyn T. Wong"'
Autor:
Lynn A. Hyde, Qi Zhang, Robert A. Del Vecchio, Prescott T. Leach, Mary E. Cohen-Williams, Lei Chen, Gwendolyn T. Wong, Nansie A. McHugh, Joseph Chen, Guy A. Higgins, Theodros Asberom, Wei Li, Dmitri Pissarnitski, Diane Levitan, Amin A. Nomeir, John W. Clader, Lili Zhang, Eric M. Parker
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2013 (2013)
Substantial evidence implicates -amyloid (A) peptides in the etiology of Alzheimer’s disease (AD). A is produced by the proteolytic cleavage of the amyloid precursor protein by - and -secretase suggesting that -secretase inhibition may provide ther
Externí odkaz:
https://doaj.org/article/992cb89d5ff04869837af4acc77fb5af
Autor:
Leonard Favreau, Dmitri A. Pissarnitski, Eric M. Parker, Zhiqiang Zhao, Lili Zhang, Hubert B. Josien, Lynn A. Hyde, Gwendolyn T. Wong, Theodros Asberom, John W. Clader, Thomas A. Bara, Murali Rajagopalan, Amin A. Nomeir, William J. Greenlee, Qi Zhang, Lixin Song
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5330-5335
The design and development of a new class of small 2,6-disubstituted piperidine N-arylsulfonamide gamma-secretase inhibitors is reported. Lowering molecular weight including the use of conformational constraint led to compounds with less CYP 3A4 liab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5957002f712a344f6f56d867f752f6cb
https://doi.org/10.1016/j.bmcl.2007.08.013
https://doi.org/10.1016/j.bmcl.2007.08.013
Autor:
Lynn A. Hyde, John W. Clader, Eric M. Parker, Zhiqiang Zhao, Lili Zhang, Andrew T. McPhail, Lixin Song, Amin A. Nomeir, Gwendolyn T. Wong, Wei Li, William J. Greenlee, Qi Zhang, Hubert B. Josien, Murali Rajagopalan, Dmitri A. Pissarnitski, Thomas A. Bara, Theodros Asberom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:511-516
Attachment of the cyclopropylcarbamate group to the piperidine core of gamma-secretase inhibitors leads to a dramatic increase of their in vitro potency. Strategies for subsequent improvement of the in vivo pharmacokinetic profile of the series are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051de6e906c5c30c98a730a305bf4f61
https://doi.org/10.1016/j.bmcl.2006.10.011
https://doi.org/10.1016/j.bmcl.2006.10.011
Publikováno v:
The Journal of Neuroscience. 24:3444-3452
Overwhelming evidence indicates that the effects of β-amyloid (Aβ) are dose dependent bothin vitroandin vivo, which implies that Aβ is not directly detrimental to brain cells until it reaches a threshold concentration. In an effort to understand e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17805b5654aa1e531273d90addb758b4
https://doi.org/10.1523/jneurosci.4856-03.2004
https://doi.org/10.1523/jneurosci.4856-03.2004
Autor:
Maureen Maguire, Marvin L. Bayne, Hu-Jung J. Lee, Brian E. Hawes, Suke Wang, Ling Pang, Gwendolyn T. Wong, Tanaz Hashemi, Michael P. Graziano
Publikováno v:
Journal of Neurochemistry. 71:2252-2259
The diverse physiological actions of galanin are thought to be mediated through activation of galanin receptors (GalRs). We report the genomic and cDNA cloning of a mouse GalR that possesses a genomic structure distinct from that of GalR1 and encodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e088b9eaf98614eaee255f663e3dac2
https://doi.org/10.1046/j.1471-4159.1998.71062252.x
https://doi.org/10.1046/j.1471-4159.1998.71062252.x
Publikováno v:
Proceedings of the National Academy of Sciences. 98:8868-8873
Biochemical and genetic studies have implicated α-gustducin as a key component in the transduction of both bitter or sweet taste. Yet, α-gustducin-null mice are not completely unresponsive to bitter or sweet compounds. To gain insights into how gus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e12f013cbc63bfc186c3da412ef599
https://doi.org/10.1073/pnas.151235798
https://doi.org/10.1073/pnas.151235798
Autor:
Dmitri A. Pissarnitski, Guy A. Higgins, Theodros Asberom, Robert A. Del Vecchio, Qi Zhang, Joseph C. Chen, Nansie A. McHugh, Amin A. Nomeir, Lynn A. Hyde, Lei Chen, Lili Zhang, Mary Cohen-Williams, Eric M. Parker, Wei Li, John W. Clader, Prescott T. Leach, Gwendolyn T. Wong, Diane Levitan
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2013 (2013)
International Journal of Alzheimer's Disease
International Journal of Alzheimer's Disease
Substantial evidence implicates β-amyloid (Aβ) peptides in the etiology of Alzheimer's disease (AD). Aβ is produced by the proteolytic cleavage of the amyloid precursor protein by β- and γ-secretase suggesting that γ-secretase inhibition may pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ded8fb0ec20a4a99c2908c401ca6c7
Publikováno v:
Nature. 381:796-800
Several lines of evidence suggest that both sweet and bitter tastes are transduced via receptors coupled to heterotrimeric guanine-nucleotide-binding proteins (G proteins). Gustducin is a taste receptor cell (TRC)-specific G protein that is closely r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbda16acd9edef232c2d6d5f712b95bc
https://doi.org/10.1038/381796a0
https://doi.org/10.1038/381796a0
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 61:173-184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17e3ad4c74a18a796673f309ac045380
https://doi.org/10.1101/sqb.1996.061.01.020
https://doi.org/10.1101/sqb.1996.061.01.020
Autor:
Yong Gao, Kerstin Forsberg, Susie Stephens, Eric K. Neumann, Donald Doherty, Vipul Kashyap, William J. Bug, Elizabeth Wu, Olivier Bodenreider, Davide Zaccagnini, Jonathan Rees, Joanne S. Luciano, Gwendolyn T. Wong, Alan Ruttenberg, Timothy Clark, M. Scott Marshall, Tonya Hongsermeier, Matthias Samwald, Ivan Herman, Helen H. Chen, Kei-Hoi Cheung, June Kinoshita, Chimezie Ogbuji
Publikováno v:
BMC Bioinformatics, 8(Suppl. 3). BioMed Central
BMC Bioinformatics
BMC Bioinformatics, Vol 8, Iss Suppl 3, p S2 (2007)
BMC Bioinformatics
BMC Bioinformatics, Vol 8, Iss Suppl 3, p S2 (2007)
Background A fundamental goal of the U.S. National Institute of Health (NIH) "Roadmap" is to strengthen Translational Research, defined as the movement of discoveries in basic research to application at the clinical level. A significant barrier to tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5047a723ccad1f542b8494a3b8524edb
https://doi.org/10.1186/1471-2105-8-s3-s2
https://doi.org/10.1186/1471-2105-8-s3-s2