Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gwendolyn R. Bylebyl"'
Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells
Autor:
Tianbao Lu, Jennifer Lattanze, Ingrid Deckman, Marie Zhang, Bruce L. Grasberger, Carl L. Manthey, and Christopher J. Molloy, John C. Spurlino, Diane M. Maguire, Eugene C. Petrella, Kannan Ramachandren, Holly K. Koblish, Shuyuan Zhao, Bruce E. Tomczuk, Gwendolyn R. Bylebyl, Louis V. LaFrance, Carsten Schubert, Daniel J. Parks, Karen L. Milkiewicz, Carol F. Franks, Theodore E. Carver, Roger F. Bone, Anna C. Maroney, Maxwell D. Cummings, Raul R. Calvo, W. Michael Avondale Pantoliano
Publikováno v:
Journal of Medicinal Chemistry. 48:909-912
HDM2 binds to an alpha-helical transactivation domain of p53, inhibiting its tumor suppressive functions. A miniaturized thermal denaturation assay was used to screen chemical libraries, resulting in the discovery of a novel series of benzodiazepined
Publikováno v:
Journal of Biological Chemistry. 278:44113-44120
The ubiquitin-related protein SUMO functions by becoming covalently attached to lysine residues in other proteins. Unlike ubiquitin, which is often linked to its substrates as a polyubiquitin chain, only one SUMO moiety is attached per modified site
Autor:
Gwendolyn R. Bylebyl, Alison Reindle, Xiaole L. Chen, Irina Belichenko, Erica S. Johnson, Nishant Gandhi
Publikováno v:
Journal of cell science. 119(Pt 22)
Saccharomyces cerevisiae contains two Siz/PIAS SUMO E3 ligases, Siz1 and Siz2/Nfi1, and one other known ligase, Mms21. Although ubiquitin ligases are highly substrate-specific, the degree to which SUMO ligases target distinct sets of substrates is un
Autor:
Mihajlo L. Krsmanovic, Gwendolyn R. Bylebyl, Shelley L. Berger, Kristin Ingvarsdottir, Milos Dokmanovic, Kelly A. Whelan, David E. Sterner, Erica S. Johnson, Dafna Nathan, Pamela B. Meluh, Jean Dorsey, William S. Lane
Covalent histone post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitylation play pivotal roles in regulating many cellular processes, including transcription, response to DNA damage, and epigenetic control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611ef5ae31145cb1d389242edda32f63
https://europepmc.org/articles/PMC1472304/
https://europepmc.org/articles/PMC1472304/