Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gwendolyn M. Swarbrick"'
Autor:
Corinna A. Kulicke, Gwendolyn M. Swarbrick, Nicole A. Ladd, Meghan Cansler, Megan Null, Aneta Worley, Chance Lemon, Tania Ahmed, Joshua Bennett, Taylor N. Lust, Chelsea M. Heisler, Megan E. Huber, Jason R. Krawic, Laurisa M. Ankley, Savannah K. McBride, Fikadu G. Tafesse, Andrew J. Olive, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen presentation pathways
Externí odkaz:
https://doaj.org/article/a188a5d473ac493d8d7f9aa7fe4c7e44
Autor:
Haihong Jin, Nicole A. Ladd, Andrew M. Peev, Gwendolyn M. Swarbrick, Meghan Cansler, Megan Null, Christopher T. Boughter, Curtis McMurtrey, Aaron Nilsen, Karen M. Dobos, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a result, there is considerable inter
Externí odkaz:
https://doaj.org/article/2922d25154b844d9be6d978cad284414
Autor:
Gwendolyn M. Swarbrick, Anele Gela, Meghan E. Cansler, Megan D. Null, Rowan B. Duncan, Elisa Nemes, Muki Shey, Mary Nsereko, Harriet Mayanja-Kizza, Sarah Kiguli, Jeffrey Koh, Willem A. Hanekom, Mark Hatherill, Christina Lancioni, David M. Lewinsohn, Thomas J. Scriba, Deborah A. Lewinsohn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, MR1, the most highly conserved MHC class I related molecule in mammalian species. Mucosal-associated inva
Externí odkaz:
https://doaj.org/article/ebbba450db45408db25d0ba79dc4e891
Autor:
Deborah A. Lewinsohn, Gwendolyn M. Swarbrick, Byung Park, Meghan E. Cansler, Megan D. Null, Katelynne G. Toren, Joy Baseke, Sarah Zalwango, Harriet Mayanja-Kizza, LaShaunda L. Malone, Melissa Nyendak, Guanming Wu, Kristi Guinn, Shannon McWeeney, Tomi Mori, Keith A. Chervenak, David R. Sherman, W. Henry Boom, David M. Lewinsohn
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-11 (2017)
Tuberculosis: Defining the proteins that drive immune responses Specific bacterial proteins have been found that drive effective immune responses to tuberculosis, with use in making more effective vaccines. Immunity to tuberculosis (TB) is facilitate
Externí odkaz:
https://doaj.org/article/6a7fcb5a9dd24cd682d8a9c35d006ba1
Autor:
Corinna A. Kulicke, Gwendolyn M. Swarbrick, Nicole A. Ladd, Meghan Cansler, Megan Null, Aneta Worley, Chance Lemon, Tania Ahmed, Joshua Bennett, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff
MR1 restricted T (MR1T) cells have the potential to be important players in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f7579befb7ce71c2259b1405b333358
https://doi.org/10.1101/2022.07.11.499573
https://doi.org/10.1101/2022.07.11.499573
Autor:
Curtis McMurtrey, Melanie J Harriff, Gwendolyn M Swarbrick, Amanda Duncan, Meghan Cansler, Megan Null, Wilfried Bardet, Kenneth W Jackson, Deborah A Lewinsohn, William Hildebrand, David M Lewinsohn
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188288 (2017)
HLA-E is a non-conventional MHC Class I molecule that has been recently demonstrated to present pathogen-derived ligands, resulting in the TCR-dependent activation of αβ CD8+ T cells. The goal of this study was to characterize the ligandome display
Externí odkaz:
https://doaj.org/article/f64969aaea6d4b79b6c16dd832a1f814
Autor:
Deborah A Lewinsohn, Ervina Winata, Gwendolyn M Swarbrick, Katie E Tanner, Matthew S Cook, Megan D Null, Meghan E Cansler, Alessandro Sette, John Sidney, David M Lewinsohn
Publikováno v:
PLoS Pathogens, Vol 3, Iss 9, Pp 1240-1249 (2007)
CD8(+) T cells are essential for host defense to intracellular bacterial pathogens such as Mycobacterium tuberculosis (Mtb), Salmonella species, and Listeria monocytogenes, yet the repertoire and dominance pattern of human CD8 antigens for these path
Externí odkaz:
https://doaj.org/article/54e61ced89fa4f0ba33a1e189f2fa87f
Autor:
David M Lewinsohn, Gwendolyn M Swarbrick, Meghan E Cansler, Megan D Null, Veena Rajaraman, Marisa M Frieder, David R Sherman, Shannon McWeeney, Deborah A Lewinsohn
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67016 (2013)
Identification of CD8(+) T cell antigens/epitopes expressed by human pathogens with large genomes is especially challenging, yet necessary for vaccine development. Immunity to tuberculosis, a leading cause of mortality worldwide, requires CD8(+) T ce
Externí odkaz:
https://doaj.org/article/caec2d302f0845fe8d833eae5dde3992
Autor:
Marielle C Gold, Stefania Cerri, Susan Smyk-Pearson, Meghan E Cansler, Todd M Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M Swarbrick, Wei-Jen Chua, Yik Y L Yu, Olivier Lantz, Matthew S Cook, Megan D Null, David B Jacoby, Melanie J Harriff, Deborah A Lewinsohn, Ted H Hansen, David M Lewinsohn
Publikováno v:
PLoS Biology, Vol 8, Iss 6, p e1000407 (2010)
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilu
Externí odkaz:
https://doaj.org/article/d438072d9b3a4f378beabc48f892f372
Autor:
Robynn V Schillace, Casey L Miller, Neal Pisenti, Jeff E Grotzke, Gwendolyn M Swarbrick, David M Lewinsohn, Daniel W Carr
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4807 (2009)
BACKGROUND: Dendritic cells (DC) are the most potent antigen presenting cells (APC) of the immune system. Prostaglandin E(2), cyclic AMP, and protein kinase A (PKA) have all been shown to regulate DC maturation and activity. In other cells, the abili
Externí odkaz:
https://doaj.org/article/68c4b5d89bde4720ae0c76ca86cbacca