Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Gwendolyn M. Pais"'
Autor:
Erin F. Barreto, PharmD, MSc, Andrew J. Webb, PharmD, Gwendolyn M. Pais, PhD, Andrew D. Rule, MD, Paul J. Jannetto, PhD, Marc H. Scheetz, PharmD, MSc
Publikováno v:
Critical Care Explorations, Vol 3, Iss 6, p e0446 (2021)
OBJECTIVES:. Beta-lactam antibiotics exhibit high interindividual variability in drug concentrations in patients with critical illness which led to an interest in the use of therapeutic drug monitoring to improve effectiveness and safety. To implemen
Externí odkaz:
https://doaj.org/article/cd67800c93d741549273a3553556cffc
Autor:
Sean N. Avedissian, Jiajun Liu, Nathaniel J. Rhodes, Andrew Lee, Gwendolyn M. Pais, Alan R. Hauser, Marc H. Scheetz
Publikováno v:
Antibiotics, Vol 8, Iss 1, p 31 (2019)
Polymyxin B remains an antibiotic of last resort because of its toxicities. Although newer therapies are becoming available, it is anticipated that resistance to these agents will continue to emerge, and understanding the safest and most efficacious
Externí odkaz:
https://doaj.org/article/6e23987c99a44d2799dc03d942076153
Autor:
Gwendolyn M. Pais, Jack Chang, Erin F. Barreto, Gideon Stitt, Kevin J. Downes, Mohammad H. Alshaer, Emily Lesnicki, Vaidehi Panchal, Maria Bruzzone, Argyle V. Bumanglag, Sara N. Burke, Marc H. Scheetz
Publikováno v:
Clin Pharmacokinet
Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against Gram-positive and Gram-negative pathogens. It is generally administered as an infusion over 30-60 min or as a prolonged infusion with infusion times from 3 h to contin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f069cf168beead7aa1e1b8b93cf722
https://doi.org/10.1007/s40262-022-01137-y
https://doi.org/10.1007/s40262-022-01137-y
Autor:
Jack Chang, Gwendolyn M. Pais, Sylwia Marianski, Kimberly Valdez, Emily Lesnicki, Erin F. Barreto, Nathaniel J. Rhodes, Paul R. Yarnold, Marc H. Scheetz
Recent clinical studies have reported additive nephrotoxicity with the combination of vancomycin and piperacillin-tazobactam. However, preclinical models have failed to replicate this finding. This study assessed differences in iohexol-measured glome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6404f69d878d40c24b8051533ecc40b
https://doi.org/10.1101/2023.03.09.532007
https://doi.org/10.1101/2023.03.09.532007
Autor:
Jack Chang, Gwendolyn M. Pais, Patti L. Engel, Patryk Klimek, Sylwia Marianski, Kimberly Valdez, Marc H. Scheetz
Vancomycin induced kidney injury is common, and outcomes in humans are well predicted by animal models. This study employed our translational rat model to investigate temporal changes in glomerular filtration rate (GFR) and correlation with kidney in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a366b6b9ce624a3c97cd597c5687f2ac
https://doi.org/10.1101/2022.09.26.509628
https://doi.org/10.1101/2022.09.26.509628
Autor:
Marc H Scheetz, Jack Chang, Erin F Barreto, Anand Srivastava, Kimberly Valdez, Sylwia Marianski, Gwendolyn M Pais, Todd Miano
Publikováno v:
Clinical Infectious Diseases. 76:1521-1522
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6215c3a13e5744535c73cfb26bc81498
https://doi.org/10.1093/cid/ciac958
https://doi.org/10.1093/cid/ciac958
Autor:
Johid R. Malik, Courtney V. Fletcher, Anthony T. Podany, Shetty Ravi Dyavar, Kimberly K. Scarsi, Gwendolyn M. Pais, Marc H. Scheetz, Sean N. Avedissian
Publikováno v:
Journal of Neuroscience Methods. 392:109867
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44b6d3d9c6c70fec5b9c5e45b2d7a0bc
https://doi.org/10.1016/j.jneumeth.2023.109867
https://doi.org/10.1016/j.jneumeth.2023.109867
Autor:
Emily Lesnicki, Gwendolyn M. Pais, Sylwia Marianski, Kimberly Valdez, Zoe Gibson, Jeffri Christopher, Marc H. Scheetz
BackgroundIn high dose, cefepime causes neurotoxicity in patients with kidney injury; however, the relationship between exposure and observed neurotoxicity is not clear, and no animal model presently recapitulates the human condition.ObjectivesThis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80785d8cf8ebb5feb3a91ccbd02e31e2
https://doi.org/10.1101/2022.05.26.493582
https://doi.org/10.1101/2022.05.26.493582
Autor:
Sean N. Avedissian, Gwendolyn M. Pais, Michelle Pham, Jiajun Liu, Jack Chang, Khrystyna Hlukhenka, Walter Prozialeck, Brooke Griffin, Anil Gulati, Medha D. Joshi, Ying Mu, Marc H. Scheetz
Publikováno v:
Antimicrob Agents Chemother
Vancomycin usage is often unavoidable in pregnant patients; however, literature suggests vancomycin can cross the placental barrier and reach the fetus. Understanding the mass transit of vancomycin to the fetus is important in pregnancy. We aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d2594641eadc84726e056a64994506
https://doi.org/10.1128/aac.00056-22
https://doi.org/10.1128/aac.00056-22
Publikováno v:
Int J Antimicrob Agents
Vancomycin (VAN) causes acute kidney injury as defined by serum creatinine (SCr) increase. Glomerular filtration rate (GFR) is the gold standard for defining kidney function, and SCr is often used as a GFR surrogate; however, SCr changes can lag behi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f330b5071379100fbb8f67bb1ffe9c
https://europepmc.org/articles/PMC10119746/
https://europepmc.org/articles/PMC10119746/