Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gwendolyn M Jang"'
Autor:
Tyler B Faust, Yang Li, Curtis W Bacon, Gwendolyn M Jang, Amit Weiss, Bhargavi Jayaraman, Billy W Newton, Nevan J Krogan, Iván D'Orso, Alan D Frankel
Publikováno v:
eLife, Vol 7 (2018)
The HIV-1 Tat protein hijacks P-TEFb kinase to activate paused RNA polymerase II (RNAP II) at the viral promoter. Tat binds additional host factors, but it is unclear how they regulate RNAP II elongation. Here, we identify the cytoplasmic ubiquitin l
Externí odkaz:
https://doaj.org/article/4861f751eab349dcb5a30cc8610f90bd
Autor:
Nevan J. Krogan, Trey Ideker, Jennifer R. Grandis, Jason F. Kreisberg, Jacques Archambault, Toni M. Brand, Priya S. Shah, Gwendolyn M. Jang, Tasha L. Johnson, Danielle L. Swaney, Kathleen E. Franks-Skiba, Jeffrey R. Johnson, John Von Dollen, Andrew M. Gross, Wei Zhang, Manon Eckhardt
Previously Reported HPV-Human PPIs. Related to Figures 1 and 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d454025b1a979d87b79d7d615efd42
https://doi.org/10.1158/2159-8290.22531720.v1
https://doi.org/10.1158/2159-8290.22531720.v1
Autor:
Nevan J. Krogan, Trey Ideker, Jennifer R. Grandis, Jason F. Kreisberg, Jacques Archambault, Toni M. Brand, Priya S. Shah, Gwendolyn M. Jang, Tasha L. Johnson, Danielle L. Swaney, Kathleen E. Franks-Skiba, Jeffrey R. Johnson, John Von Dollen, Andrew M. Gross, Wei Zhang, Manon Eckhardt
This combined Supplementary Document contains Supplementary Notes, Methods and References, Legends to Supplementary Tables S1-S6, and Supplementary Figures S1-S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ce492afaaf23b83d30432f2d7be132
https://doi.org/10.1158/2159-8290.22531723
https://doi.org/10.1158/2159-8290.22531723
Autor:
Adriana Pitea, Rigney E Turnham, Manon Eckhardt, Gwendolyn M Jang, Zhong Xu, Huat C Lim, Alex Choi, John Von Dollen, Rebecca S. Levin, James T Webber, Elizabeth McCarthy, Junjie Hu, Xiaolei Li, Li Che, Gary Chan, R. Katie Kelley, Danielle Swaney, Wei Zhang, Sourav Bandyopadhyay, Fabian J Theis, Xin Chen, Kevan Shokat, Trey Ideker, Nevan J Krogan, John D Gordan
SummaryInfection by hepatitis B virus (HBV) increases risk for liver cancer by inducing inflammation, cellular stress and cell death. To elucidate the molecular pathways by which HBV promotes cancer development and progression, we used affinity purif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c06cf8a0185f305c549a512f7867853
https://doi.org/10.1101/2023.03.15.532845
https://doi.org/10.1101/2023.03.15.532845
Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories
Autor:
Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn M. Jang, Jiewei Xu, Jack M. Moen, Alicia Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Giuditta De Lorenzo, Vanessa Cowton, Abdullah M. Syed, Alison Ciling, Noa Deutsch, Daniel Pirak, Giulia Dowgier, Dejan Mesner, Jane L. Turner, Briana L. McGovern, M. Luis Rodriguez, Rocio Leiva-Rebollo, Alistair S. Dunham, Xiaofang Zhong, Manon Eckhardt, Andrea Fossati, Nicholas Liotta, Thomas Kehrer, Anastasija Cupic, Magda Rutkowska, Nacho Mena, Sadaf Aslam, Alyssa Hoffert, Helene Foussard, John Pham, Molly Lyons, Laura Donahue, Aliesha Griffin, Rebecca Nugent, Kevin Holden, Robert Deans, Pablo Aviles, José Antonio López-Martín, Jose M. Jimeno, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Ruth Hüttenhain, Irwin Jungreis, Manolis Kellis, Ignacia Echeverria, Kliment Verba, Paola Bonfanti, Pedro Beltrao, Roded Sharan, Jennifer A. Doudna, Luis Martinez-Sobrido, Arvind Patel, Massimo Palmarini, Lisa Miorin, Kris White, Danielle L. Swaney, Adolfo García-Sastre, Clare Jolly, Lorena Zuliani-Alvarez, Greg J. Towers, Nevan J. Krogan
A series of SARS-CoV-2 variants of concern (VOCs) have evolved in humans during the COVID-19 pandemic—Alpha, Beta, Gamma, Delta, and Omicron. Here, we used global proteomic and genomic analyses during infection to understand the molecular responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8567a33da825246dd5aa0c0571375e
https://doi.org/10.1101/2022.10.19.512927
https://doi.org/10.1101/2022.10.19.512927
Autor:
Christine E. Peters, Ursula Schulze-Gahmen, Manon Eckhardt, Gwendolyn M. Jang, Jiewei Xu, Ernst H. Pulido, Conner Bardine, Charles S. Craik, Melanie Ott, Or Gozani, Kliment A. Verba, Ruth Hüttenhain, Jan E. Carette, Nevan J. Krogan
Publikováno v:
Nature communications, vol 13, iss 1
Enteroviruses cause a number of medically relevant and widespread human diseases with no approved antiviral therapies currently available. Host-directed therapies present an enticing option for this diverse genus of viruses. We have previously identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0903254045ac12c061f581dbceab41b6
https://doi.org/10.1038/s41467-022-32758-3
https://doi.org/10.1038/s41467-022-32758-3
Autor:
Zeynep Cakir, Samuel J. Lord, Yuan Zhou, Gwendolyn M. Jang, Benjamin J. Polacco, Manon Eckhardt, David Jimenez-Morales, Billy W. Newton, Adam L. Orr, Jeffrey R. Johnson, Alexandre da Cruz, R. Dyche Mullins, Nevan J. Krogan, Robert W. Mahley, Danielle L. Swaney
Publikováno v:
Molecular & cellular proteomics : MCP, vol 22, iss 5
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease. While neurons generally produce a minority of the apoE in the central nervous system, neuronal expression of apoE increases dramatically in response to stress and is su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647c091248c059db9dbcf0b93760d397
https://doi.org/10.1101/2022.06.06.495052
https://doi.org/10.1101/2022.06.06.495052
Autor:
John Gordan, Adriana Pitea, Rigney E Turnham, Manon Eckhardt, Gwendolyn M Jang, Huat Lim, Alex L Choi, Sourav Bandyopadhyay, Danielle Swaney, Kevan Shokat, Trey Ideker, Nevan Krogan
Publikováno v:
Clinical Cancer Research. 28:PO017-PO017
Viral hepatitis promotes hepatocellular carcinoma (HCC) initiation by inducing inflammation, cellular stress and cell death. However, the cell-intrinsic effects of viral infection in advanced HCC remain unclear. We used affinity purification mass spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dbf2af265501e48311abb5719f30533
https://doi.org/10.1158/1557-3265.liverca22-po017
https://doi.org/10.1158/1557-3265.liverca22-po017
Autor:
Natalia Jura, Jeffrey R. Johnson, Nevan J. Krogan, Małgorzata Dudkiewicz, Krzysztof Pawłowski, John Von Dollen, Mitchell L. Lopez, Megan Lo, Gwendolyn M. Jang, Jennifer E. Kung
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 31
Members of the New Kinase Family 3 (NKF3), PEAK1/SgK269 and Pragmin/SgK223 pseudokinases, have emerged as important regulators of cell motility and cancer progression. Here, we demonstrate that C19orf35 (PEAK3), a newly identified member of the NKF3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab312a4809bcc4e136506a2e16b194b5
https://doi.org/10.1073/pnas.1906360116
https://doi.org/10.1073/pnas.1906360116
Autor:
Jessica K. Peters, Natalia Jura, Aye C. Thwin, Mehdi Bouhaddou, Fei Li, Jocelyne Lopez, Yang Li, Kuei-Ho Chen, Erron W. Titus, Huong T. Kratochvil, Victor L Lam, Christian B. Billesbølle, Tristan W. Owens, Raphael Trenker, Axel F. Brilot, Danielle L. Swaney, Ursula Schulze-Gahmen, Feng Wang, Gregory E. Merz, Jen Chen, Amy Diallo, Yang Zhang, Adam Frost, Soumya G. Remesh, Junrui Li, Edmond Linossi, Fengbo Zhou, Maliheh Safari, Yifan Cheng, Henry C. Nguyen, Andrea Fossati, Devan Diwanji, Evelyn Hernandez, Aashish Manglik, Nevan J. Krogan, Iris D. Young, Jianhua Zhao, Kyle E. Lopez, Alexandrea N. Rizo, Megan Lo, Thomas H. Pospiech, Gwendolyn M. Jang, Y. Li, Sergei Pourmal, Yuan Zhou, Miles Sasha Dickinson, Un Seng Chio, Kaihua Zhang, Caleigh M. Azumaya, Michael D Paul, Oren S. Rosenberg, Yanxin Liu, Tsz Kin Martin Tsui, Carlos Nowotny, Kate Kim, Kliment A. Verba, Loan Doan, Zanlin Yu, Adrian Pelin, Mariano C Tabios, Lorena Zuliani-Alvarez, Daniel R. Southworth, Melody G. Campbell, Ming Sun, Adamo Mancino, Kaitlin Schaefer, Frank R. Moss, Daniel Asarnow, Meghna Gupta, James S. Fraser, Komal Ishwar Pawar, Amber M. Smith, Robert M. Stroud, Tanja Kortemme, Cristina Puchades, Michelle Moritz, Nadia Herrera, Eric Tse, Mingliang Jin, David A. Agard
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv, vol 2, iss 05-19
Research Square
article-version (status) pre
article-version (number) 1
bioRxiv, vol 2, iss 05-19
Research Square
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis of those functions, remain unknown. Here, we report an atomic model for full-length Nsp2 obtained by combining cryo-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8c3bdd782cfa56f525ccd0d1740780
https://pubmed.ncbi.nlm.nih.gov/34013269
https://pubmed.ncbi.nlm.nih.gov/34013269