Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gwendolyn D, Fate"'
Autor:
Sunil Nepal, Mark E. Savage, Kimberly Y. Smith, Manoli Vourvahis, Phylinda L. S. Chan, Srinivas Rao Valluri, Julian J Haynes, Lynn McFadyen, Jayvant Heera, Andrew Clark, Linda S. Wood, Annie Fang, Gwendolyn D. Fate, Angus N. R. Nedderman, Jean-Claude Marshall
Publikováno v:
Journal of Clinical Pharmacology
Maraviroc is a C‐C chemokine receptor type‐5 antagonist approved for the treatment of HIV‐1. Previous studies show that cytochrome P450 3A5 (CYP3A5) plays a role in maraviroc metabolism. CYP3A5 is subject to a genetic polymorphism. The presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163186c5f22a0287699d825327c2ada7
https://pubmed.ncbi.nlm.nih.gov/30192390
https://pubmed.ncbi.nlm.nih.gov/30192390
Autor:
Gwendolyn D. Fate, Gregory L. Finch, Steven Bailey, Daniel Morton, Peter J. Thomford, Christopher Houle, Prashant R. Nambiar, Leland Wayne Dochterman
Publikováno v:
Toxicologic Pathology. 43:354-365
Administration of lersivirine, a nonnucleotide reverse transcriptase inhibitor, daily by oral gavage to Sprague-Dawley rats for up to 2 yr was associated with decreased survival, decreased body weights, and an increase in neoplasms and related prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e381add7cf3eecdcaeee1e9b43a2d9
https://doi.org/10.1177/0192623314544381
https://doi.org/10.1177/0192623314544381
Autor:
F. Barclay Shilliday, Xiaojun Fang, Chungang Gu, Daniel P. Walker, Gwendolyn D. Fate, Bruce A. Thornburgh, J. Scott Daniels
Publikováno v:
Drug Metabolism Letters. 4:163-172
The quinuclidine PHA-0568487(1) is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e777b592b0219f5ae9e7adaf437509
https://doi.org/10.2174/187231210791698429
https://doi.org/10.2174/187231210791698429
Autor:
Jeffery J. Prusakiewicz, Gwendolyn D. Fate, Richard Voorman, Chrisita Ackermann, Faith M. Williams, Christopher Jewell, N. Ann Payne
Publikováno v:
Toxicology and Applied Pharmacology. 225:221-228
Parabens are esters of 4-hydroxybenzoic acid and used as anti-microbial agents in a wide variety of toiletries, cosmetics and pharmaceuticals. It is of interest to understand the dermal absorption and hydrolysis of parabens, and to evaluate their dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1991aedb97de7eb2e2a458ff3b6c93
https://doi.org/10.1016/j.taap.2007.08.002
https://doi.org/10.1016/j.taap.2007.08.002
Autor:
Christopher Jewell, Jeffery J. Prusakiewicz, N. Ann Payne, Gwendolyn D. Fate, Chrisita Ackermann, Faith M. Williams
Publikováno v:
Toxicology Letters. 173:118-123
Skin esterases serve an important pharmacological function as they can be utilised for activation of topically applied ester prodrugs. Understanding the nature of these enzymes, with respect to their role and local activity, is essential to defining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299e9967fc09fe58d1bf4bbe17d52790
https://doi.org/10.1016/j.toxlet.2007.07.004
https://doi.org/10.1016/j.toxlet.2007.07.004
Publikováno v:
Drug Metabolism and Disposition. 34:1615-1623
The metabolism and excretion of N-(3R)-1-azabicyclo[2.2.2]oct-3-ylfuro[2,3-c]pyridine-5-carboxamide (1), an agonist of the alpha7 nicotinic acetylcholinergic receptor, were determined in both Sprague-Dawley rats and beagle dogs using [3H]1. Initially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f21687fac539c61dcffdfcfd984f32b
https://doi.org/10.1124/dmd.106.010934
https://doi.org/10.1124/dmd.106.010934
Publikováno v:
Journal of Chromatography A. 824:25-33
Several derivatization approaches for a cyclic, fermentation derived peptide analog were investigated. The most viable derivatization reagent, 5-[2-(and-3)- S -(acetylmercapto)succinoyl)-amino]fluorescein (SAMSA-FL), derivatized the analyte through a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42ecbe19e5355d99a1ff7bf6c2a4f567
https://doi.org/10.1016/s0021-9673(98)00612-8
https://doi.org/10.1016/s0021-9673(98)00612-8
Autor:
Brian D. Kaluzny, J. Gordon Marr, Frank W. Crow, Gary E. Martin, Terry J. Gilbertson, Gwendolyn D. Fate
Publikováno v:
Magnetic Resonance in Chemistry. 36:635-644
Early efforts to utilize 15N NMR spectroscopy in structure elucidation studies were often frustrated by the low gyromagnetic ratio (γN) and the low natural abundance (0.37%) of the nuclide. The advent of 1H and inverse-detected 2D NMR methods has el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56d516c6d19b52f14f87324125b1d504
https://doi.org/10.1002/(sici)1097-458x(199809)36:9<635::aid-omr348>3.0.co
https://doi.org/10.1002/(sici)1097-458x(199809)36:9<635::aid-omr348>3.0.co
Publikováno v:
Journal of the American Chemical Society. 118:2347-2358
The use of weak, intermolecular forces to orchestrate the contruction of multicomponent systems in membranes has significant implications in diverse areas of chemistry, biology, and medicine. We describe here the construction and characterization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d44c89344419a55490ab0a1c9766ed0
https://doi.org/10.1021/ja953092e
https://doi.org/10.1021/ja953092e
Publikováno v:
Journal of the American Chemical Society. 118:11363-11368
U-102408 has been isolated from S. arginensis cultures and fully characterized by NMR and MS. These studies indicate that U-102408 is identical with sulfomycin, and this data confirm the structure of sulfomycin which was assigned by chemical degradat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa3fd68d70efb47b53414ea0452067d
https://doi.org/10.1021/ja961864g
https://doi.org/10.1021/ja961864g