Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Gwendolyn A Sowa"'
Autor:
Mingkuan Lin, Wan Huang, Nadine Kabbani, Mark M Theiss, John F Hamilton, James M Ecklund, Yvette P Conley, Yoram Vodovotz, David Brienza, Amy K Wagner, Emily Robbins, Gwendolyn A Sowa, Robert H Lipsky
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251110 (2021)
The α7 neuronal nicotinic acetylcholine receptors (α7nAChRs) are essential for anti-inflammatory responses. The human-specific CHRFAM7A gene and its 2bp deletion polymorphism (Δ2bp variant) encodes a structurally-deficient α7nAChRs that may impac
Externí odkaz:
https://doaj.org/article/4a386b81cf444528804f9e1a7194413f
Autor:
Cordelia Ziraldo, Alexey Solovyev, Ana Allegretti, Shilpa Krishnan, M Kristi Henzel, Gwendolyn A Sowa, David Brienza, Gary An, Qi Mi, Yoram Vodovotz
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 6, p e1004309 (2015)
People with spinal cord injury (SCI) are predisposed to pressure ulcers (PU). PU remain a significant burden in cost of care and quality of life despite improved mechanistic understanding and advanced interventions. An agent-based model (ABM) of isch
Externí odkaz:
https://doaj.org/article/66c3864b9b14470a9db7f411bc12a800
Autor:
Keith G Avin, Paul M Coen, Wan eHuang, Donna eStolz, Gwendolyn A Sowa, John J Dubé, Bret H Goodpaster, Robert eO’Doherty, Fabrisia eAmbrosio
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity. While an association betwee
Externí odkaz:
https://doaj.org/article/ef1de8c7bf5f4d32ac339aa95eeebc9e
Autor:
Takashi Yurube, William J. Buchser, Zhongying Zhang, Prashanta Silwal, Michael T. Lotze, James D. Kang, Gwendolyn A. Sowa, Nam V. Vo
Publikováno v:
JOR Spine, Vol 7, Iss 1, Pp n/a-n/a (2024)
Abstract Background Low back pain is a global health problem that originated mainly from intervertebral disc degeneration (IDD). Autophagy, negatively regulated by the phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) si
Externí odkaz:
https://doaj.org/article/b7cf96995ccc4069bbbcd8d157c03fbb
Autor:
Richard A. Wawrose, Brandon K. Couch, Malcom Dombrowski, Stephen R. Chen, Anthony Oyekan, Qing Dong, Dong Wang, Chaoming Zhou, Joseph Chen, Karthik Modali, Marit Johnson, Zachary Sedor‐Schiffhauer, T. Kevin Hitchens, Tao Jin, Kevin M. Bell, Joon Y. Lee, Gwendolyn A. Sowa, Nam V. Vo
Publikováno v:
JOR Spine, Vol 5, Iss 2, Pp n/a-n/a (2022)
Abstract Background Previous animal models of intervertebral disc degeneration (IDD) rely on open surgical approaches, which confound the degenerative response and pain behaviors due to injury to surrounding tissues during the surgical approach. To o
Externí odkaz:
https://doaj.org/article/c098b58d597b48c6b5c6bdc04c0dfd07
Autor:
Anthony Delitto, Charity G. Patterson, Joel M. Stevans, Janet K. Freburger, Samannaaz S. Khoja, Michael J. Schneider, Carol M. Greco, Jennifer A. Freel, Gwendolyn A. Sowa, Ajay D. Wasan, Gerard P. Brennan, Stephen J. Hunter, Kate I. Minick, Stephen T. Wegener, Patti L. Ephraim, Jason M. Beneciuk, Steven Z. George, Robert B. Saper
Publikováno v:
EClinicalMedicine, Vol 34, Iss , Pp 100795- (2021)
Background: Many patients with acute low back pain (LBP) first seek care from primary care physicians. Evidence is lacking for interventions to prevent transition to chronic LBP in this setting. We aimed to test if implementation of a risk-stratified
Externí odkaz:
https://doaj.org/article/5f84f8fb856d44ef8dae580f29954883
Autor:
Jiongbiao Zhong, Joseph Chen, Anthony A. Oyekan, Michael W. Epperly, Joel S. Greenberger, Joon Y. Lee, Gwendolyn A. Sowa, Nam V. Vo
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 4014 (2022)
Previous research has identified an association between external radiation and disc degeneration, but the mechanism was poorly understood. This study explores the effects of ionizing radiation (IR) on inducing cellular senescence of annulus fibrosus
Externí odkaz:
https://doaj.org/article/470a5555f0c847d4bdcd836ea7bbce2c
Autor:
Elizabeth A. Capogna, Emma Brown, Evan Walrath, William Furst, Qing Dong, Chao-Ming Zhou, Sarah E. Gullbrand, Nam V. Vo, Gwendolyn A. Sowa, Eric H. Ledet
Publikováno v:
European Spine Journal. 31:1088-1098
Autor:
Richard A. Wawrose, Anthony A. Oyekan, Yunting Melissa Tang, Stephen R. Chen, Joseph Chen, Brandon K. Couch, Dong Wang, Peter G. Alexander, Gwendolyn A. Sowa, Nam V. Vo, Joon Y. Lee
Publikováno v:
European Spine Journal.
Autor:
Nam V Vo, Sara R Piva, Charity G Patterson, Gina P McKernan, Leming Zhou, Kevin M Bell, William Anderst, Carol M Greco, Michael J Schneider, Anthony Delitto, Brad E Dicianno, Jessa Darwin, Gwendolyn A Sowa
Publikováno v:
Pain Medicine.
As a member of the Back Pain Consortium (BACPAC), the University of Pittsburgh Mechanistic Research Center's research goal is to phenotype chronic low back pain using biological, biomechanical, and behavioral domains using a prospective, observationa